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Items: 1 to 20 of 56

1.

Dasatinib

A pyrimidine and thiazole derived ANTINEOPLASTIC AGENT and PROTEIN KINASE INHIBITOR of BCR-ABL KINASE. It is used in the treatment of patients with CHRONIC MYELOID LEUKEMIA who are resistant or intolerant to IMATINIB. [from MeSH]

MedGen UID:
305964
Concept ID:
C1455147
Organic Chemical; Pharmacologic Substance
2.

Imatinib

An antineoplastic agent that inhibits the Bcr-Abl fusion protein tyrosine kinase, an abnormal enzyme produced by chronic myeloid leukemia cells that contain the Philadelphia chromosome. Imatinib also inhibits the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and stem cell factor (SCF)/c-kit; the SCF/c-kit receptor tyrosine kinase is activated in gastrointestinal stromal tumor (GIST). This agent inhibits proliferation and induces apoptosis in cells that overexpress these oncoproteins. [from NCI]

MedGen UID:
183186
Concept ID:
C0935989
Organic Chemical; Pharmacologic Substance
3.

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. [from HPO]

MedGen UID:
9725
Concept ID:
C0023418
Neoplastic Process
4.

ph+++

MedGen UID:
623899
Concept ID:
C0450409
Finding
5.

ph++

MedGen UID:
623898
Concept ID:
C0450408
Finding
6.

ph+

MedGen UID:
623897
Concept ID:
C0450407
Finding
7.

Acute lymphoblastic leukemia

A form of acute leukemia characterized by excess lympoblasts. [from HPO]

MedGen UID:
505958
Concept ID:
CN005851
Finding
8.

Ph-positive acute lymphoblastic leukemia

MedGen UID:
473500
Concept ID:
C1960397
Neoplastic Process
9.

Positive

Involving advantage or good. [from NCI]

MedGen UID:
254858
Concept ID:
C1446409
Finding
10.

Acute lymphoid leukemia

Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL (Trevino et al., 2009). Genetic Heterogeneity of Acute Lymphoblastic Leukemia A susceptibility locus for acute lymphoblastic leukemia (ALL1) has been mapped to chromosome 10q21. See also ALL2 (613067), which has been mapped to chromosome 7p12.2; and ALL3 (615545), which is caused by mutation in the PAX5 gene (167414) on chromosome 9p. [from GTR]

MedGen UID:
7317
Concept ID:
C0023449
Neoplastic Process
11.

Pleural effusion

Increased amounts of fluid within the pleural cavity. Symptoms include shortness of breath, cough, and chest pain. It is usually caused by lung infections, congestive heart failure, pleural and lung tumors, connective tissue disorders, and trauma. [from NCI]

MedGen UID:
10805
Concept ID:
C0032227
Disease or Syndrome
12.

Philadelphia Chromosome

A translocation between chromosomes 9 and 22. It is the hallmark for chronic myelogenous leukemia (CML). [from NCI]

MedGen UID:
10715
Concept ID:
C0031526
Pathologic Function
13.

Hematologic Response

An evaluation of the hematologic response of the disease to the therapy. [from NCI]

MedGen UID:
885726
Concept ID:
C4054793
Finding
14.

Cytogenetic Response

An evaluation of the cytogenetic response of the disease to the therapy. [from NCI]

MedGen UID:
883494
Concept ID:
C4055168
Finding
15.

Indicated

MedGen UID:
731837
Concept ID:
C1444656
Finding
16.

Improved

Condition changed and/or recovered [from CCC]

MedGen UID:
512204
Concept ID:
C0184511
Finding
17.

Chronic myelogenous leukemia

A myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. [from HPO]

MedGen UID:
505815
Concept ID:
CN004875
Finding
18.

Grade 1

A morphologic qualifier indicating that a cancerous lesion is well differentiated. [from NCI]

MedGen UID:
146365
Concept ID:
C0687695
Finding
19.

Chronic

Slow, creeping onset, slow progress and long continuance of disease manifestations. [from HPO]

MedGen UID:
104657
Concept ID:
C0205191
Temporal Concept
20.

Acute

Sudden appearance of disease manifestations over a short period of time. [from HPO]

MedGen UID:
61381
Concept ID:
C0205178
Temporal Concept
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