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Items: 17

1.

Busulfan

A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04) [from NCI]

MedGen UID:
2386
Concept ID:
C0006463
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
2.

Pancytopenia

A finding of low numbers of red and white blood cells and platelets in the peripheral blood. [from NCI]

MedGen UID:
18281
Concept ID:
C0030312
Disease or Syndrome
3.

progressive

MedGen UID:
851455
Concept ID:
CN232553
Finding
4.

Absence

MedGen UID:
739164
Concept ID:
C1689985
Anatomical Abnormality
5.

Prolonged

Applied to an abnormality whose duration is extended over a longer period of time than is expected or usual (e.g., prolonged fever lasts longer than one usually sees with an infection). [from HPO]

MedGen UID:
615082
Concept ID:
C0439590
Temporal Concept
6.

Proliferation

MedGen UID:
137720
Concept ID:
C0334094
Pathologic Function
7.

Progressive

Advancing in extent or severity. [from NCI]

MedGen UID:
64400
Concept ID:
C0205329
Functional Concept
8.

Abnormal

Deviating in any way from the state, position, structure, condition, behavior, or rule which is considered a norm. [from NCI]

MedGen UID:
59964
Concept ID:
C0205161
Finding
9.

Stress

The negative mental, emotional, and physical reactions that occur when environmental stressors are perceived as exceeding the individual's adaptive capacities. [from NCI]

MedGen UID:
20971
Concept ID:
C0038435
Finding
10.

Mylecytan

MedGen UID:
196395
Concept ID:
C0728927
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
11.

Busulfex

MedGen UID:
184873
Concept ID:
C0939273
Organic Chemical; Pharmacologic Substance
12.

Myelosan

MedGen UID:
152611
Concept ID:
C0728926
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
13.

Glyzophrol

MedGen UID:
152610
Concept ID:
C0728924
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
14.

Myleran

MedGen UID:
148565
Concept ID:
C0700015
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
15.

Alcohol

A class of compounds where a hydroxyl (OH) group is attached to single bonded hydrocarbons. Alcohols are classified according to the position of the carbon atom with the attached hydroxyl group (i.e. primary alcohols are alcohols with the OH group attached to the primary carbon atom, C1). Uses include solvents, astringents, and anti-infective activity. [from NCI]

MedGen UID:
1400
Concept ID:
C0001975
Organic Chemical; Pharmacologic Substance
16.

Wellcome, Busulfan

MedGen UID:
304722
Concept ID:
C1451652
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
17.

Pancytopenia due to antineoplastic chemotherapy

MedGen UID:
928238
Concept ID:
C4302569
Disease or Syndrome
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