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ABT-888

MedGen UID:
321856
Concept ID:
C1831920
Organic Chemical; Pharmacologic Substance
Synonyms: ABT 888; ABT888
 

Definition

A poly(ADP-ribose) polymerase (PARP) -1 and -2 inhibitor with chemosensitizing and antitumor activities. With no antiproliferative effects as a single agent at therapeutic concentrations, ABT-888 inhibits PARPs, thereby inhibiting DNA repair and potentiating the cytotoxicity of DNA-damaging agents. PARP nuclear enzymes are activated by DNA single or double strand breaks, resulting in the poly(ADP-ribosyl)ation of other nuclear DNA binding proteins involved in DNA repair; poly(ADP-ribosyl)ation contributes to efficient DNA repair and to survival of proliferating cells exposed to mild genotoxic stresses as induced by as oxidants, alkylating agents or ionizing radiation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=496464&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=496464&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C60768" NCI Thesaurus) [from PDQ]

Recent clinical studies

Etiology

Reiss KA, Herman JM, Armstrong D, Zahurak M, Fyles A, Brade A, Milosevic M, Dawson LA, Scardina A, Fischer P, Hacker-Prietz A, Kinders RJ, Wang L, Chen A, Temkin S, Horiba N, Stayner LA, Siu LL, Azad NS
Gynecol Oncol 2017 Mar;144(3):486-490. Epub 2017 Jan 18 doi: 10.1016/j.ygyno.2017.01.016. PMID: 28109627Free PMC Article
Robins HI, Zhang P, Gilbert MR, Chakravarti A, de Groot JF, Grimm SA, Wang F, Lieberman FS, Krauze A, Trotti AM, Mohile N, Kee AY, Colman H, Cavaliere R, Kesari S, Chmura SJ, Mehta M
J Neurooncol 2016 Jan;126(2):309-16. Epub 2015 Oct 27 doi: 10.1007/s11060-015-1966-z. PMID: 26508094Free PMC Article
Middleton MR, Friedlander P, Hamid O, Daud A, Plummer R, Falotico N, Chyla B, Jiang F, McKeegan E, Mostafa NM, Zhu M, Qian J, McKee M, Luo Y, Giranda VL, McArthur GA
Ann Oncol 2015 Oct;26(10):2173-9. Epub 2015 Jul 22 doi: 10.1093/annonc/mdv308. PMID: 26202595
Lin F, de Gooijer MC, Roig EM, Buil LC, Christner SM, Beumer JH, Würdinger T, Beijnen JH, van Tellingen O
Clin Cancer Res 2014 May 15;20(10):2703-13. Epub 2014 Mar 19 doi: 10.1158/1078-0432.CCR-14-0084. PMID: 24647572
Clark CC, Weitzel JN, O'Connor TR
Mol Cancer Ther 2012 Sep;11(9):1948-58. Epub 2012 Jul 9 doi: 10.1158/1535-7163.MCT-11-0597. PMID: 22778154Free PMC Article

Diagnosis

Reiss KA, Herman JM, Armstrong D, Zahurak M, Fyles A, Brade A, Milosevic M, Dawson LA, Scardina A, Fischer P, Hacker-Prietz A, Kinders RJ, Wang L, Chen A, Temkin S, Horiba N, Stayner LA, Siu LL, Azad NS
Gynecol Oncol 2017 Mar;144(3):486-490. Epub 2017 Jan 18 doi: 10.1016/j.ygyno.2017.01.016. PMID: 28109627Free PMC Article
Balvers RK, Lamfers ML, Kloezeman JJ, Kleijn A, Berghauser Pont LM, Dirven CM, Leenstra S
J Transl Med 2015 Feb 26;13:74. doi: 10.1186/s12967-015-0427-y. PMID: 25886061Free PMC Article
Guillot C, Favaudon V, Herceg Z, Sagne C, Sauvaigo S, Merle P, Hall J, Chemin I
BMC Cancer 2014 Aug 20;14:603. doi: 10.1186/1471-2407-14-603. PMID: 25139788Free PMC Article
Su JM, Thompson P, Adesina A, Li XN, Kilburn L, Onar-Thomas A, Kocak M, Chyla B, McKeegan E, Warren KE, Goldman S, Pollack IF, Fouladi M, Chen A, Giranda V, Boyett J, Kun L, Blaney SM
Neuro Oncol 2014 Dec;16(12):1661-8. Epub 2014 Jun 7 doi: 10.1093/neuonc/nou103. PMID: 24908656Free PMC Article
Palma JP, Wang YC, Rodriguez LE, Montgomery D, Ellis PA, Bukofzer G, Niquette A, Liu X, Shi Y, Lasko L, Zhu GD, Penning TD, Giranda VL, Rosenberg SH, Frost DJ, Donawho CK
Clin Cancer Res 2009 Dec 1;15(23):7277-90. Epub 2009 Nov 24 doi: 10.1158/1078-0432.CCR-09-1245. PMID: 19934293

Therapy

Reiss KA, Herman JM, Armstrong D, Zahurak M, Fyles A, Brade A, Milosevic M, Dawson LA, Scardina A, Fischer P, Hacker-Prietz A, Kinders RJ, Wang L, Chen A, Temkin S, Horiba N, Stayner LA, Siu LL, Azad NS
Gynecol Oncol 2017 Mar;144(3):486-490. Epub 2017 Jan 18 doi: 10.1016/j.ygyno.2017.01.016. PMID: 28109627Free PMC Article
Siddharth S, Nayak D, Nayak A, Das S, Kundu CN
DNA Repair (Amst) 2016 Sep;45:44-55. Epub 2016 Jun 3 doi: 10.1016/j.dnarep.2016.05.034. PMID: 27334689
Lemasson B, Wang H, Galbán S, Li Y, Zhu Y, Heist KA, Tsein C, Chenevert TL, Rehemtulla A, Galbán CJ, Holland EC, Ross BD
Neoplasia 2016 Feb;18(2):82-9. doi: 10.1016/j.neo.2015.11.014. PMID: 26936394Free PMC Article
Robins HI, Zhang P, Gilbert MR, Chakravarti A, de Groot JF, Grimm SA, Wang F, Lieberman FS, Krauze A, Trotti AM, Mohile N, Kee AY, Colman H, Cavaliere R, Kesari S, Chmura SJ, Mehta M
J Neurooncol 2016 Jan;126(2):309-16. Epub 2015 Oct 27 doi: 10.1007/s11060-015-1966-z. PMID: 26508094Free PMC Article
Su JM, Thompson P, Adesina A, Li XN, Kilburn L, Onar-Thomas A, Kocak M, Chyla B, McKeegan E, Warren KE, Goldman S, Pollack IF, Fouladi M, Chen A, Giranda V, Boyett J, Kun L, Blaney SM
Neuro Oncol 2014 Dec;16(12):1661-8. Epub 2014 Jun 7 doi: 10.1093/neuonc/nou103. PMID: 24908656Free PMC Article

Prognosis

Middleton MR, Friedlander P, Hamid O, Daud A, Plummer R, Falotico N, Chyla B, Jiang F, McKeegan E, Mostafa NM, Zhu M, Qian J, McKee M, Luo Y, Giranda VL, McArthur GA
Ann Oncol 2015 Oct;26(10):2173-9. Epub 2015 Jul 22 doi: 10.1093/annonc/mdv308. PMID: 26202595
Muñoz-Gámez JA, López Viota J, Barrientos A, Carazo Á, Sanjuán-Nuñez L, Quiles-Perez R, Muñoz-de-Rueda P, Delgado Á, Ruiz-Extremera Á, Salmerón J
Liver Int 2015 Apr;35(4):1430-41. Epub 2014 Jun 3 doi: 10.1111/liv.12586. PMID: 24821649
Guillot C, Favaudon V, Herceg Z, Sagne C, Sauvaigo S, Merle P, Hall J, Chemin I
BMC Cancer 2014 Aug 20;14:603. doi: 10.1186/1471-2407-14-603. PMID: 25139788Free PMC Article
Salem AH, Giranda VL, Mostafa NM
Clin Pharmacokinet 2014 May;53(5):479-88. doi: 10.1007/s40262-013-0130-1. PMID: 24452810
Kikuchi R, Lao Y, Bow DA, Chiou WJ, Andracki ME, Carr RA, Voorman RL, De Morais SM
J Pharm Sci 2013 Dec;102(12):4426-32. Epub 2013 Oct 2 doi: 10.1002/jps.23737. PMID: 24122511

Clinical prediction guides

Reiss KA, Herman JM, Armstrong D, Zahurak M, Fyles A, Brade A, Milosevic M, Dawson LA, Scardina A, Fischer P, Hacker-Prietz A, Kinders RJ, Wang L, Chen A, Temkin S, Horiba N, Stayner LA, Siu LL, Azad NS
Gynecol Oncol 2017 Mar;144(3):486-490. Epub 2017 Jan 18 doi: 10.1016/j.ygyno.2017.01.016. PMID: 28109627Free PMC Article
Mizugaki H, Yamamoto N, Nokihara H, Fujiwara Y, Horinouchi H, Kanda S, Kitazono S, Yagishita S, Xiong H, Qian J, Hashiba H, Shepherd SP, Giranda V, Tamura T
Cancer Chemother Pharmacol 2015 Nov;76(5):1063-72. Epub 2015 Oct 3 doi: 10.1007/s00280-015-2876-7. PMID: 26433581Free PMC Article
Guillot C, Favaudon V, Herceg Z, Sagne C, Sauvaigo S, Merle P, Hall J, Chemin I
BMC Cancer 2014 Aug 20;14:603. doi: 10.1186/1471-2407-14-603. PMID: 25139788Free PMC Article
Su JM, Thompson P, Adesina A, Li XN, Kilburn L, Onar-Thomas A, Kocak M, Chyla B, McKeegan E, Warren KE, Goldman S, Pollack IF, Fouladi M, Chen A, Giranda V, Boyett J, Kun L, Blaney SM
Neuro Oncol 2014 Dec;16(12):1661-8. Epub 2014 Jun 7 doi: 10.1093/neuonc/nou103. PMID: 24908656Free PMC Article
Davidson D, Wang Y, Aloyz R, Panasci L
Invest New Drugs 2013 Apr;31(2):461-8. Epub 2012 Oct 9 doi: 10.1007/s10637-012-9886-7. PMID: 23054213Free PMC Article

Recent systematic reviews

Eliopoulos H, Giranda V, Carr R, Tiehen R, Leahy T, Gordon G
Clin Cancer Res 2008 Jun 15;14(12):3683-8. doi: 10.1158/1078-0432.CCR-07-4586. PMID: 18559583

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