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Items: 14

1.

Cystic fibrosis

Cystic fibrosis (CF) is a multisystem disease affecting epithelia of the respiratory tract, exocrine pancreas, intestine, hepatobiliary system, and exocrine sweat glands. Morbidities include progressive obstructive lung disease with bronchiectasis, frequent hospitalizations for pulmonary disease, pancreatic insufficiency and malnutrition, recurrent sinusitis and bronchitis, and male infertility. Pulmonary disease is the major cause of morbidity and mortality in CF. Meconium ileus occurs at birth in 15%-20% of newborns with CF. More than 95% of males with CF are infertile. Congenital absence of the vas deferens (CAVD) is generally identified during evaluation of infertility or as an incidental finding at the time of a surgical procedure. Hypoplasia or aplasia of the vas deferens and seminal vesicles may occur either bilaterally or unilaterally. Testicular development and function and spermatogenesis are usually normal. [from GeneReviews]

MedGen UID:
41393
Concept ID:
C0010674
Disease or Syndrome
2.

Fibrosis

formation of excess fibrous connective tissue [from CHV]

MedGen UID:
5179
Concept ID:
C0016059
Pathologic Function
3.

Adenosine

a kind of nucleic acid [from CHV]

MedGen UID:
127
Concept ID:
C0001443
Biologically Active Substance; Neuroreactive Substance or Biogenic Amine; Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
4.

Pulmonary interstitial glycogenosis

Pulmonary interstitial glycogenosis (PIG) is a rare non-lethal pediatric form of interstitial lung disease (ILD, see this term). [from ORDO]

MedGen UID:
798843
Concept ID:
CN201153
Finding
5.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
6.

Phosphodiesterase 3 Inhibitors

Compounds that specifically inhibit PHOSPHODIESTERASE 3. [from MeSH]

MedGen UID:
412207
Concept ID:
C2267032
Pharmacologic Substance
7.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
8.

colforsin

Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland. [from MeSH]

MedGen UID:
214628
Concept ID:
C0917964
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
9.

Second Messenger Systems

A non-proteinaceous signaling molecule that is generated by intracellular enzymes that respond to the binding of extracellular ligands to cell surface receptors. These compounds serve as intermediate signals for a diverse set of cellular processes. [from NCI]

MedGen UID:
19914
Concept ID:
C0036522
Molecular Function
10.

Phosphodiesterase Inhibitors

Any substance that inhibits phosphodiesterase, an enzyme that catalyzes the breaking of a phosphodiester bond. Usually, this refers to cyclic nucleotide phosphodiesterase, an enzyme that breaks the phosphodiester bond in the second messenger molecules cAMP and cGMP. Inhibition of cyclic nucleotide phosphodiesterase can be used to affect vasodilation. [from NCI]

MedGen UID:
10727
Concept ID:
C0031638
Pharmacologic Substance
11.

Enzyme Inhibitors

compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. [from CRISP]

MedGen UID:
8652
Concept ID:
C0014432
Pharmacologic Substance
12.

Cyclic adenosine monophosphate

An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH. (MeSH) [from NCI]

MedGen UID:
1328
Concept ID:
C0001455
Biologically Active Substance; Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
13.

Adenine Nucleotides

condensation product of adenosine and phosphoric acid; a nucleotide found among the hydrolysis products of all nucleic acids. [from CRISP]

MedGen UID:
120
Concept ID:
C0001413
Biologically Active Substance; Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
14.

Pletal

MedGen UID:
152511
Concept ID:
C0722654
Organic Chemical; Pharmacologic Substance
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