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Polyploidy

MedGen UID:
18567
Concept ID:
C0032578
Cell or Molecular Dysfunction
Synonyms: Polyploid; Polyploidies; Polyploids
SNOMED CT: Polyploidy syndrome (72991005); Polyploidy (72991005); Polyploidy (48099008)
 
Orphanet: ORPHA96321

Definition

The chromosomal constitution of a cell containing multiples of the normal number of CHROMOSOMES; includes triploidy (symbol: 3N), tetraploidy (symbol: 4N), etc. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolyploidy
Follow this link to review classifications for Polyploidy in Orphanet.

Recent clinical studies

Etiology

Shimono J, Miyoshi H, Seto M, Teshima T, Ohshima K
Pathol Int 2017 Jan;67(1):17-23. Epub 2016 Nov 21 doi: 10.1111/pin.12478. PMID: 27868293
Waltman LA, Eckel-Passow JE, Sharma RG, Van Dyke DL
Am J Med Genet A 2013 May;161A(5):1200-2. Epub 2013 Mar 29 doi: 10.1002/ajmg.a.35870. PMID: 23554063
Govindarajulu R, Hughes CE, Alexander PJ, Bailey CD
Am J Bot 2011 Dec;98(12):2064-76. Epub 2011 Nov 29 doi: 10.3732/ajb.1100260. PMID: 22130273
Isaac AK, Lertsburapa T, Pathria Mundi J, Martini M, Guitart J, Gerami P
Am J Dermatopathol 2010 Apr;32(2):144-8. doi: 10.1097/DAD.0b013e3181b72d6f. PMID: 20051813
Liu Y, Heilman SA, Illanes D, Sluder G, Chen JJ
Cancer Res 2007 Mar 15;67(6):2603-10. doi: 10.1158/0008-5472.CAN-06-3436. PMID: 17363579

Diagnosis

Zekri A, Ghaffari SH, Yaghmaie M, Estiar MA, Alimoghaddam K, Modarressi MH, Ghavamzadeh A
Mol Neurobiol 2016 Apr;53(3):1808-1823. Epub 2015 Mar 11 doi: 10.1007/s12035-015-9139-9. PMID: 25752998
Hansen TV, Vikesaa J, Buhl SS, Rossing HH, Timmermans-Wielenga V, Nielsen FC
BMC Cancer 2015 Feb 6;15:35. doi: 10.1186/s12885-015-1035-1. PMID: 25655188Free PMC Article
Sharma S, Yao HP, Zhou YQ, Zhou J, Zhang R, Wang MH
Mol Oncol 2014 May;8(3):469-82. Epub 2014 Jan 2 doi: 10.1016/j.molonc.2013.12.014. PMID: 24444656
Balsas P, Galán-Malo P, Marzo I, Naval J
Leuk Res 2012 Feb;36(2):212-8. Epub 2011 Oct 5 doi: 10.1016/j.leukres.2011.09.011. PMID: 21978467
Salmina K, Jankevics E, Huna A, Perminov D, Radovica I, Klymenko T, Ivanov A, Jascenko E, Scherthan H, Cragg M, Erenpreisa J
Exp Cell Res 2010 Aug 1;316(13):2099-112. Epub 2010 May 10 doi: 10.1016/j.yexcr.2010.04.030. PMID: 20457152

Therapy

Zekri A, Ghaffari SH, Yaghmaie M, Estiar MA, Alimoghaddam K, Modarressi MH, Ghavamzadeh A
Mol Neurobiol 2016 Apr;53(3):1808-1823. Epub 2015 Mar 11 doi: 10.1007/s12035-015-9139-9. PMID: 25752998
Gallala H, Winter J, Veit N, Nowak M, Perner S, Courts C, Kraus D, Janzen V, Probstmeier R
Tumour Biol 2015 Apr;36(4):2725-35. Epub 2014 Dec 7 doi: 10.1007/s13277-014-2897-6. PMID: 25487614
Krause DS, Crispino JD
Clin Cancer Res 2013 Nov 15;19(22):6084-8. Epub 2013 Aug 20 doi: 10.1158/1078-0432.CCR-12-2604. PMID: 23963861Free PMC Article
Duncan AW
Semin Cell Dev Biol 2013 Apr;24(4):347-56. Epub 2013 Jan 16 doi: 10.1016/j.semcdb.2013.01.003. PMID: 23333793
Wang Q, Wu PC, Dong DZ, Ivanova I, Chu E, Zeliadt S, Vesselle H, Wu DY
Int J Cancer 2013 Apr 1;132(7):1505-15. Epub 2012 Nov 16 doi: 10.1002/ijc.27810. PMID: 22945332

Prognosis

Sufit A, Lee-Sherick AB, DeRyckere D, Rupji M, Dwivedi B, Varella-Garcia M, Pierce AM, Kowalski J, Wang X, Frye SV, Earp HS, Keating AK, Graham DK
PLoS One 2016;11(10):e0165107. Epub 2016 Oct 26 doi: 10.1371/journal.pone.0165107. PMID: 27783662Free PMC Article
Krause DS, Crispino JD
Clin Cancer Res 2013 Nov 15;19(22):6084-8. Epub 2013 Aug 20 doi: 10.1158/1078-0432.CCR-12-2604. PMID: 23963861Free PMC Article
Mayfield-Jones D, Washburn JD, Arias T, Edger PP, Pires JC, Conant GC
Semin Cell Dev Biol 2013 Apr;24(4):320-31. Epub 2013 Mar 1 doi: 10.1016/j.semcdb.2013.02.002. PMID: 23466286
Zasadil LM, Britigan EM, Weaver BA
Semin Cell Dev Biol 2013 Apr;24(4):370-9. Epub 2013 Feb 13 doi: 10.1016/j.semcdb.2013.02.001. PMID: 23416057Free PMC Article
Wang Q, Wu PC, Dong DZ, Ivanova I, Chu E, Zeliadt S, Vesselle H, Wu DY
Int J Cancer 2013 Apr 1;132(7):1505-15. Epub 2012 Nov 16 doi: 10.1002/ijc.27810. PMID: 22945332

Clinical prediction guides

Mosieniak G, Sliwinska MA, Alster O, Strzeszewska A, Sunderland P, Piechota M, Was H, Sikora E
Neoplasia 2015 Dec;17(12):882-93. doi: 10.1016/j.neo.2015.11.008. PMID: 26696370Free PMC Article
Gallala H, Winter J, Veit N, Nowak M, Perner S, Courts C, Kraus D, Janzen V, Probstmeier R
Tumour Biol 2015 Apr;36(4):2725-35. Epub 2014 Dec 7 doi: 10.1007/s13277-014-2897-6. PMID: 25487614
Gollapudi P, Hasegawa LS, Eastmond DA
Mutat Res Genet Toxicol Environ Mutagen 2014 Jun;767:37-43. Epub 2014 Mar 26 doi: 10.1016/j.mrgentox.2014.03.004. PMID: 24680981Free PMC Article
Sharma S, Yao HP, Zhou YQ, Zhou J, Zhang R, Wang MH
Mol Oncol 2014 May;8(3):469-82. Epub 2014 Jan 2 doi: 10.1016/j.molonc.2013.12.014. PMID: 24444656
Mayfield-Jones D, Washburn JD, Arias T, Edger PP, Pires JC, Conant GC
Semin Cell Dev Biol 2013 Apr;24(4):320-31. Epub 2013 Mar 1 doi: 10.1016/j.semcdb.2013.02.002. PMID: 23466286

Recent systematic reviews

Russo A, Pacchierotti F, Cimini D, Ganem NJ, Genescà A, Natarajan AT, Pavanello S, Valle G, Degrassi F
Environ Mol Mutagen 2015 Aug;56(7):563-80. Epub 2015 Mar 18 doi: 10.1002/em.21945. PMID: 25784636
Chen H, Liu K, Chen LJ, Hou P, Chen W, Pang CP
Mol Vis 2012;18:816-29. Epub 2012 Apr 4 PMID: 22509112Free PMC Article
Maire G, Brown CW, Bayani J, Pereira C, Gravel DH, Bell JC, Zielenska M, Squire JA
Cancer Genet Cytogenet 2008 Mar;181(2):81-92. doi: 10.1016/j.cancergencyto.2007.11.002. PMID: 18295659
Zhang J, Finney RP, Rowe W, Edmonson M, Yang SH, Dracheva T, Jen J, Struewing JP, Buetow KH
Genome Res 2007 Jul;17(7):1111-7. Epub 2007 May 24 doi: 10.1101/gr.5963407. PMID: 17525135Free PMC Article
Paulus JM, Levin J, Debili N, Albert A, Vainchenker W
Exp Hematol 2001 Nov;29(11):1256-69. PMID: 11698121

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