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Items: 14

1.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
2.

Transplantation

MedGen UID:
881115
Concept ID:
CN236682
Disease or Syndrome
3.

Retinoid

A group of agents that includes retinol (Vitamin A) and related compounds with potential antineoplastic and/or chemopreventive activities. A retinoic acid agent binds to and/or activates specific nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs), thereby modulating transcription of genes responsible for cell differentiation and proliferation. A retinoic acid agent may exhibit immunomodulatory and anti-inflammatory properties and may inhibit ornithine decarboxylase, resulting in a decrease in polyamine synthesis and keratinization. (NCI04) [from NCI]

MedGen UID:
48436
Concept ID:
C0035339
Organic Chemical; Pharmacologic Substance
4.

Tretinoin

A naturally-occurring acid of retinol. Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. The oral form of tretinoin has teratogenic and embryotoxic properties. [from NCI]

MedGen UID:
21254
Concept ID:
C0040845
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
5.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
6.

Retin-A

MedGen UID:
109266
Concept ID:
C0593762
Organic Chemical; Pharmacologic Substance
7.

Vesanoid

MedGen UID:
108874
Concept ID:
C0595126
Organic Chemical; Pharmacologic Substance
8.

Retinol

The fat soluble vitamin retinol. Vitamin A binds to and activates retinoid receptors (RARs), thereby inducing cell differentiation and apoptosis of some cancer cell types and inhibiting carcinogenesis. Vitamin A plays an essential role in many physiologic processes, including proper functioning of the retina, growth and differentiation of target tissues, proper functioning of the reproductive organs, and modulation of immune function. [from NCI]

MedGen UID:
88691
Concept ID:
C0087161
Organic Chemical; Pharmacologic Substance; Vitamin
9.

Vitamin A

Retinol and derivatives of retinol that play an essential role in metabolic functioning of the retina, the growth of and differentiation of epithelial tissue, the growth of bone, reproduction, and the immune response. Dietary vitamin A is derived from a variety of CAROTENOIDS found in plants. It is enriched in the liver, egg yolks, and the fat component of dairy products. [from MeSH]

MedGen UID:
12111
Concept ID:
C0042839
Organic Chemical; Pharmacologic Substance; Vitamin
10.

Enzyme inhibitor

Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. [from MeSH]

MedGen UID:
8652
Concept ID:
C0014432
Pharmacologic Substance
11.

Carotinoid

A class of hydrocarbons (carotenes) and their oxygenated derivatives which exhibit chemopreventive properties. Carotenoids are pigments found in green, yellow, and leafy vegetables, and yellow fruits. The pigments are fat-soluble, unsaturated aliphatic hydrocarbons functioning as provitamins and are converted to vitamin A through enzymatic processes in the intestinal wall. [from NCI]

MedGen UID:
2890
Concept ID:
C0007271
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
12.

Antineoplastic agent

A substance that inhibits the maturation, growth or spread of tumor cells. [from NCI]

MedGen UID:
1984
Concept ID:
C0003392
Organic Chemical; Pharmacologic Substance
13.

C.I. Solvent Yellow 56

MedGen UID:
27707
Concept ID:
C0054395
Organic Chemical; Pharmacologic Substance
14.

Tretinoin response

MedGen UID:
450498
Concept ID:
CN078026
Sign or Symptom
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