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Items: 5

1.

Cisplatin

A drug used to treat many types of cancer. Cisplatin contains the metal platinum. It kills cancer cells by damaging their DNA and stopping them from dividing. Cisplatin is a type of alkylating agent. [from NCI_NCI-GLOSS]

MedGen UID:
40318
Concept ID:
C0008838
Inorganic Chemical; Pharmacologic Substance
2.

Etoposide

A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle. [from MeSH]

MedGen UID:
8725
Concept ID:
C0015133
Organic Chemical; Pharmacologic Substance
3.

Carcinoma

A malignant tumor arising from epithelial cells. Carcinomas that arise from glandular epithelium are called adenocarcinomas, those that arise from squamous epithelium are called squamous cell carcinomas, and those that arise from transitional epithelium are called transitional cell carcinomas (NCI Thesaurus). [from HPO]

MedGen UID:
2867
Concept ID:
C0007097
Neoplastic Process
4.

Carcinoma

MedGen UID:
910818
Concept ID:
CN241453
Finding
5.

Neuroendocrine Carcinoma

A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma. [from NCI]

MedGen UID:
104919
Concept ID:
C0206695
Neoplastic Process
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