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Erythropoietin

MedGen UID:
41863
Concept ID:
C0014822
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
Synonyms: EPO - Erythropoietin; Erythropoietin preparation; Erythropoietin stimulating agent; ESA - Erythropoietin stimulating agent
SNOMED CT: EPO - Erythropoietin (83042003); Erythropoietin (83042003); Erythropoietin preparation (111167001); ESA - Erythropoietin stimulating agent (111167001); Erythropoietin stimulating agent (111167001)
 

Definition

Glycoprotein hormone, secreted chiefly by the KIDNEY in the adult and the LIVER in the FETUS, that acts on erythroid stem cells of the BONE MARROW to stimulate proliferation and differentiation. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVErythropoietin

Recent clinical studies

Etiology

Mjønes PG, Nordrum IS, Qvigstad G, Sørdal Ø, Rian LL, Waldum HL
APMIS 2017 Mar;125(3):213-222. doi: 10.1111/apm.12654. PMID: 28233444
Steppich B, Groha P, Ibrahim T, Schunkert H, Laugwitz KL, Hadamitzky M, Kastrati A, Ott I; Regeneration of Vital Myocardium in ST-Segment Elevation Myocardial Infarction by Erythropoietin (REVIVAL-3) Study Investigators.
BMC Cardiovasc Disord 2017 Jan 21;17(1):38. doi: 10.1186/s12872-016-0464-3. PMID: 28109258Free PMC Article
Čubranić A, Dobrila-Dintinjana R, Redžović A, Dintinjana M, Petranović D, Golčić M
Med Hypotheses 2016 Nov;96:16-19. Epub 2016 Sep 24 doi: 10.1016/j.mehy.2016.09.017. PMID: 27959268
Tankiewicz-Kwedlo A, Hermanowicz J, Surażynski A, Rożkiewicz D, Pryczynicz A, Domaniewski T, Pawlak K, Kemona A, Pawlak D
Mol Cell Biochem 2016 Oct;421(1-2):1-18. Epub 2016 Aug 20 doi: 10.1007/s11010-016-2779-x. PMID: 27543111Free PMC Article
Voorn VM, van der Hout A, So-Osman C, Vliet Vlieland TP, Nelissen RG, van den Akker-van Marle ME, Dahan A, Marang-van de Mheen PJ, van Bodegom-Vos L
Vox Sang 2016 Oct;111(3):219-225. Epub 2016 Jun 17 doi: 10.1111/vox.12412. PMID: 27314459

Diagnosis

Ashby D, Busbridge M, Hildebrand S, Clarke C, Aldous G, Palan M, Murphy K, Duncan N, Choi P
Clin Nephrol 2017 May;87 (2017)(5):231-236. doi: 10.5414/CN108906. PMID: 28291504
Mjønes PG, Nordrum IS, Qvigstad G, Sørdal Ø, Rian LL, Waldum HL
APMIS 2017 Mar;125(3):213-222. doi: 10.1111/apm.12654. PMID: 28233444
Nafar M, Samavat S, Khoshdel A, Alipour-Abedi B
Iran J Kidney Dis 2017 Jan;11(1):56-65. PMID: 28174354
Bejder J, Aachmann-Andersen NJ, Bonne TC, Olsen NV, Nordsborg NB
Drug Test Anal 2016 Oct;8(10):1049-1055. Epub 2015 Dec 21 doi: 10.1002/dta.1932. PMID: 27696774
Garimella PS, Katz R, Patel KV, Kritchevsky SB, Parikh CR, Ix JH, Fried LF, Newman AB, Shlipak MG, Harris TB, Sarnak MJ; Health ABC Study.
Circ Heart Fail 2016 Jan;9(1):e002124. doi: 10.1161/CIRCHEARTFAILURE.115.002124. PMID: 26721912Free PMC Article

Therapy

Steppich B, Groha P, Ibrahim T, Schunkert H, Laugwitz KL, Hadamitzky M, Kastrati A, Ott I; Regeneration of Vital Myocardium in ST-Segment Elevation Myocardial Infarction by Erythropoietin (REVIVAL-3) Study Investigators.
BMC Cardiovasc Disord 2017 Jan 21;17(1):38. doi: 10.1186/s12872-016-0464-3. PMID: 28109258Free PMC Article
Wassink G, Davidson JO, Dhillon SK, Fraser M, Galinsky R, Bennet L, Gunn AJ
J Cereb Blood Flow Metab 2017 Mar;37(3):1080-1094. Epub 2016 Jul 20 doi: 10.1177/0271678X16650455. PMID: 27207167Free PMC Article
Bianchi S, Fusi J, Franzoni F, Giovannini L, Galetta F, Mannari C, Guidotti E, Tocchini L, Santoro G
Biomed Pharmacother 2016 Aug;82:355-63. Epub 2016 May 25 doi: 10.1016/j.biopha.2016.05.022. PMID: 27470373
Voorn VM, van der Hout A, So-Osman C, Vliet Vlieland TP, Nelissen RG, van den Akker-van Marle ME, Dahan A, Marang-van de Mheen PJ, van Bodegom-Vos L
Vox Sang 2016 Oct;111(3):219-225. Epub 2016 Jun 17 doi: 10.1111/vox.12412. PMID: 27314459
Saitoh M, Hatanaka M, Konishi M, Ishida J, Palus S, Ebner N, Döhner W, von Haehling S, Anker SD, Springer J
Int J Cardiol 2016 Sep 1;218:312-317. Epub 2016 May 14 doi: 10.1016/j.ijcard.2016.05.008. PMID: 27240157

Prognosis

Drohomirecka A, Kuśmierczyk M, Kocańda S, Kuśmierski K, Kołsut P, Kotliński K, Brutkiewicz A, Religa G, Różański J, Zieliński T
Kardiol Pol 2017;75(5):470-475. Epub 2017 Feb 2 doi: 10.5603/KP.a2017.0017. PMID: 28150286
Steppich B, Groha P, Ibrahim T, Schunkert H, Laugwitz KL, Hadamitzky M, Kastrati A, Ott I; Regeneration of Vital Myocardium in ST-Segment Elevation Myocardial Infarction by Erythropoietin (REVIVAL-3) Study Investigators.
BMC Cardiovasc Disord 2017 Jan 21;17(1):38. doi: 10.1186/s12872-016-0464-3. PMID: 28109258Free PMC Article
Čubranić A, Dobrila-Dintinjana R, Redžović A, Dintinjana M, Petranović D, Golčić M
Med Hypotheses 2016 Nov;96:16-19. Epub 2016 Sep 24 doi: 10.1016/j.mehy.2016.09.017. PMID: 27959268
Garimella PS, Katz R, Patel KV, Kritchevsky SB, Parikh CR, Ix JH, Fried LF, Newman AB, Shlipak MG, Harris TB, Sarnak MJ; Health ABC Study.
Circ Heart Fail 2016 Jan;9(1):e002124. doi: 10.1161/CIRCHEARTFAILURE.115.002124. PMID: 26721912Free PMC Article
Ward D, Carter D, Homer M, Marucci L, Gampel A
Haematologica 2016 Mar;101(3):286-96. Epub 2015 Nov 20 doi: 10.3324/haematol.2015.133637. PMID: 26589912Free PMC Article

Clinical prediction guides

Drohomirecka A, Kuśmierczyk M, Kocańda S, Kuśmierski K, Kołsut P, Kotliński K, Brutkiewicz A, Religa G, Różański J, Zieliński T
Kardiol Pol 2017;75(5):470-475. Epub 2017 Feb 2 doi: 10.5603/KP.a2017.0017. PMID: 28150286
Bejder J, Aachmann-Andersen NJ, Bonne TC, Olsen NV, Nordsborg NB
Drug Test Anal 2016 Oct;8(10):1049-1055. Epub 2015 Dec 21 doi: 10.1002/dta.1932. PMID: 27696774
Tankiewicz-Kwedlo A, Hermanowicz J, Surażynski A, Rożkiewicz D, Pryczynicz A, Domaniewski T, Pawlak K, Kemona A, Pawlak D
Mol Cell Biochem 2016 Oct;421(1-2):1-18. Epub 2016 Aug 20 doi: 10.1007/s11010-016-2779-x. PMID: 27543111Free PMC Article
Srinivasan R, Fredy IC, Chandrashekar S, Saravanan J, Mohanta GP, Manna PK
Biomed Pharmacother 2016 Aug;82:44-8. Epub 2016 May 4 doi: 10.1016/j.biopha.2016.04.041. PMID: 27470337
Guarienti M, Giacopuzzi E, Gianoncelli A, Sigala S, Spano P, Pecorelli S, Pani L, Memo M
Pharmacol Res 2015 Dec;102:12-21. Epub 2015 Sep 8 doi: 10.1016/j.phrs.2015.09.004. PMID: 26361727

Recent systematic reviews

Metta MK, Malkhed V, Tantravahi S, Vuruputuri U, Kunaparaju R
Protein J 2017 Apr;36(2):112-122. doi: 10.1007/s10930-017-9704-3. PMID: 28280963
Penny-Dimri JC, Cochrane AD, Perry LA, Smith JA
Heart Lung Circ 2016 Nov;25(11):1067-1076. Epub 2016 May 16 doi: 10.1016/j.hlc.2016.04.016. PMID: 27523464
Voorn VM, van der Hout A, So-Osman C, Vliet Vlieland TP, Nelissen RG, van den Akker-van Marle ME, Dahan A, Marang-van de Mheen PJ, van Bodegom-Vos L
Vox Sang 2016 Oct;111(3):219-225. Epub 2016 Jun 17 doi: 10.1111/vox.12412. PMID: 27314459
Sriram S, Xenocostas A, Lazo-Langner A
Hematology 2016 May;21(4):234-40. Epub 2016 Jan 8 doi: 10.1080/10245332.2015.1101972. PMID: 26747131
Xin H, Ge YZ, Wu R, Yin Q, Zhou LH, Shen JW, Lu TZ, Hu ZK, Wang M, Zhou CC, Wu JP, Li WC, Zhu JG, Jia RP
Biomed Pharmacother 2015 Feb;69:29-33. Epub 2014 Nov 6 doi: 10.1016/j.biopha.2014.10.029. PMID: 25661334

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