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AIDS

MedGen UID:
99
Concept ID:
C0001175
Disease or Syndrome
Synonyms: Acquired Immune Deficiency Syndrome; Acquired Immuno Deficiency Syndrome; Acquired Immuno-Deficiency Syndrome; Acquired Immuno-Deficiency Syndromes; Acquired Immunodeficiency Syndrome; Acquired Immunodeficiency Syndromes; Immuno-Deficiency Syndrome, Acquired; Immuno-Deficiency Syndromes, Acquired; Immunodeficiency Syndrome, Acquired; Immunodeficiency Syndromes, Acquired; Immunologic Deficiency Syndrome, Acquired; Syndrome, Acquired Immuno-Deficiency; Syndrome, Acquired Immunodeficiency; Syndromes, Acquired Immuno-Deficiency; Syndromes, Acquired Immunodeficiency
SNOMED CT: AIDS (62479008); Acquired immune deficiency syndrome (62479008); Acquired immunodeficiency syndrome (62479008); Acquired immune deficiency syndrome (AIDS) (62479008); Immunodeficiency due to human immunodeficiency virus infection (62479008); AIDS - Acquired immunodeficiency syndrome (62479008)
 

Definition

A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin lymphoma and Kaposi sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAIDS

Recent clinical studies

Etiology

Talbert-Slagle KM, Canavan ME, Rogan EM, Curry LA, Bradley EH
AIDS 2016 Feb 20;30(4):657-63. doi: 10.1097/QAD.0000000000000978. PMID: 26605512Free PMC Article
Maffongelli G, Alteri C, Gentilotti E, Bertoli A, Ricciardi A, Malagnino V, Svicher V, Santoro MM, Dori L, Perno CF, Andreoni M, Sarmati L
AIDS 2016 Mar 13;30(5):731-41. doi: 10.1097/QAD.0000000000000977. PMID: 26595543Free PMC Article
Bradshaw D, Msemburi W, Dorrington R, Pillay-van Wyk V, Laubscher R, Groenewald P; South African National Burden of Disease Study team.
AIDS 2016 Mar 13;30(5):771-8. doi: 10.1097/QAD.0000000000000947. PMID: 26509830
Mathers BM, Degenhardt L
AIDS 2014 Nov;28 Suppl 4:S435-44. doi: 10.1097/QAD.0000000000000435. PMID: 25409098Free PMC Article
Qian S, Guo W, Xing J, Qin Q, Ding Z, Chen F, Peng Z, Wang L
AIDS 2014 Jul 31;28(12):1805-13. doi: 10.1097/QAD.0000000000000323. PMID: 24906111

Diagnosis

Shiels MS, Althoff KN, Pfeiffer RM, Achenbach CJ, Abraham AG, Castilho J, Cescon A, D'Souza G, Dubrow R, Eron JJ, Gebo K, John Gill M, Goedert JJ, Grover S, Hessol NA, Justice A, Kitahata M, Mayor A, Moore RD, Napravnik S, Novak RM, Thorne JE, Silverberg MJ, Engels EA; North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of the International Epidemiologic Databases to Evaluate AIDS (IeDEA).
Clin Infect Dis 2017 Feb 15;64(4):468-475. doi: 10.1093/cid/ciw764. PMID: 27940936
Siewe B, Pham JT, Cohen M, Hessol NA, Levine A, Martinez-Maza O, Landay A
AIDS 2015 Aug 24;29(13):1659-64. doi: 10.1097/QAD.0000000000000687. PMID: 26372276Free PMC Article
Uldrick TS, Pipkin S, Scheer S, Hessol NA
AIDS 2014 Jan 28;28(3):397-405. doi: 10.1097/QAD.0000000000000030. PMID: 24076659Free PMC Article
Schwarcz L, Chen MJ, Vittinghoff E, Hsu L, Schwarcz S
AIDS 2013 Feb 20;27(4):597-605. doi: 10.1097/QAD.0b013e32835b0fa2. PMID: 23079812
Pipkin S, Scheer S, Okeigwe I, Schwarcz S, Harris DH, Hessol NA
AIDS 2011 Feb 20;25(4):463-71. doi: 10.1097/QAD.0b013e32834344e6. PMID: 21139489Free PMC Article

Therapy

Maffongelli G, Alteri C, Gentilotti E, Bertoli A, Ricciardi A, Malagnino V, Svicher V, Santoro MM, Dori L, Perno CF, Andreoni M, Sarmati L
AIDS 2016 Mar 13;30(5):731-41. doi: 10.1097/QAD.0000000000000977. PMID: 26595543Free PMC Article
Mathers BM, Degenhardt L
AIDS 2014 Nov;28 Suppl 4:S435-44. doi: 10.1097/QAD.0000000000000435. PMID: 25409098Free PMC Article
AIDS 2014 Oct 23;28(16):2461-73. doi: 10.1097/QAD.0000000000000456. PMID: 25265230Free PMC Article
Galli L, Spagnuolo V, Poli A, Salpietro S, Gianotti N, Cossarini F, Carbone A, Nozza S, Bossolasco S, Bigoloni A, Lazzarin A, Castagna A
AIDS 2014 Oct 23;28(16):2407-15. doi: 10.1097/QAD.0000000000000443. PMID: 25160933
Mocroft A, Phillips AN, Gatell J, Horban A, Ledergerber B, Zilmer K, Jevtovic D, Maltez F, Podlekareva D, Lundgren JD; EuroSIDA study in EuroCOORD.
AIDS 2013 Mar 27;27(6):907-18. doi: 10.1097/QAD.0b013e32835cb766. PMID: 23698060

Prognosis

Bradshaw D, Msemburi W, Dorrington R, Pillay-van Wyk V, Laubscher R, Groenewald P; South African National Burden of Disease Study team.
AIDS 2016 Mar 13;30(5):771-8. doi: 10.1097/QAD.0000000000000947. PMID: 26509830
Mathers BM, Degenhardt L
AIDS 2014 Nov;28 Suppl 4:S435-44. doi: 10.1097/QAD.0000000000000435. PMID: 25409098Free PMC Article
Murphy K, Hoover DR, Shi Q, Cohen M, Gandhi M, Golub ET, Gustafson DR, Pearce CL, Young M, Anastos K
AIDS 2013 Sep 24;27(15):2413-23. doi: 10.1097/01.aids.0000432537.92958.73. PMID: 24037210Free PMC Article
Mocroft A, Phillips AN, Gatell J, Horban A, Ledergerber B, Zilmer K, Jevtovic D, Maltez F, Podlekareva D, Lundgren JD; EuroSIDA study in EuroCOORD.
AIDS 2013 Mar 27;27(6):907-18. doi: 10.1097/QAD.0b013e32835cb766. PMID: 23698060
Schwarcz L, Chen MJ, Vittinghoff E, Hsu L, Schwarcz S
AIDS 2013 Feb 20;27(4):597-605. doi: 10.1097/QAD.0b013e32835b0fa2. PMID: 23079812

Clinical prediction guides

Shiels MS, Althoff KN, Pfeiffer RM, Achenbach CJ, Abraham AG, Castilho J, Cescon A, D'Souza G, Dubrow R, Eron JJ, Gebo K, John Gill M, Goedert JJ, Grover S, Hessol NA, Justice A, Kitahata M, Mayor A, Moore RD, Napravnik S, Novak RM, Thorne JE, Silverberg MJ, Engels EA; North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of the International Epidemiologic Databases to Evaluate AIDS (IeDEA).
Clin Infect Dis 2017 Feb 15;64(4):468-475. doi: 10.1093/cid/ciw764. PMID: 27940936
Duffau P, Wittkop L, Lazaro E, le Marec F, Cognet C, Blanco P, Moreau JF, Dauchy FA, Cazanave C, Vandenhende MA, Bonnet F, Thiebaut R, Pellegrin I; ANRS CO3 Aquitaine Cohort Study Group.
AIDS 2015 Oct 23;29(16):2099-108. doi: 10.1097/QAD.0000000000000807. PMID: 26544576
Murphy K, Hoover DR, Shi Q, Cohen M, Gandhi M, Golub ET, Gustafson DR, Pearce CL, Young M, Anastos K
AIDS 2013 Sep 24;27(15):2413-23. doi: 10.1097/01.aids.0000432537.92958.73. PMID: 24037210Free PMC Article
Schwarcz L, Chen MJ, Vittinghoff E, Hsu L, Schwarcz S
AIDS 2013 Feb 20;27(4):597-605. doi: 10.1097/QAD.0b013e32835b0fa2. PMID: 23079812
Reekie J, Gatell JM, Yust I, Bakowska E, Rakhmanova A, Losso M, Krasnov M, Francioli P, Kowalska JD, Mocroft A; EuroSIDA in EuroCoord.
AIDS 2011 Nov 28;25(18):2259-68. doi: 10.1097/QAD.0b013e32834cdb4b. PMID: 21918422

Recent systematic reviews

Ferguson MA, Kitterick PT, Chong LY, Edmondson-Jones M, Barker F, Hoare DJ
Cochrane Database Syst Rev 2017 Sep 25;9:CD012023. doi: 10.1002/14651858.CD012023.pub2. PMID: 28944461
Stacey D, Légaré F, Lewis K, Barry MJ, Bennett CL, Eden KB, Holmes-Rovner M, Llewellyn-Thomas H, Lyddiatt A, Thomson R, Trevena L
Cochrane Database Syst Rev 2017 Apr 12;4:CD001431. doi: 10.1002/14651858.CD001431.pub5. PMID: 28402085
Poorolajal J, Hooshmand E, Mahjub H, Esmailnasab N, Jenabi E
Public Health 2016 Oct;139:3-12. Epub 2016 Jun 24 doi: 10.1016/j.puhe.2016.05.004. PMID: 27349729
Freiberg A, Euler U, Girbig M, Nienhaus A, Freitag S, Seidler A
Int Arch Occup Environ Health 2016 May;89(4):547-59. Epub 2015 Oct 14 doi: 10.1007/s00420-015-1094-2. PMID: 26467839
Mathers BM, Degenhardt L
AIDS 2014 Nov;28 Suppl 4:S435-44. doi: 10.1097/QAD.0000000000000435. PMID: 25409098Free PMC Article

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