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Items: 20

1.

Insulin resistance

Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels. [from HPO]

MedGen UID:
43904
Concept ID:
C0021655
Pathologic Function
2.

Increased body weight

A change in overall body weight, relative to the beginning of the collection period. [from NCI]

MedGen UID:
12145
Concept ID:
C0043094
Finding
3.

Polyphagia

A neurological anomaly with gross overeating associated with an abnormally strong desire or need to eat. [from HPO]

MedGen UID:
9369
Concept ID:
C0020505
Finding; Mental or Behavioral Dysfunction
4.

Insulin

Insulin (51 aa, ~6 kDa) is encoded by the human INS gene. This protein is involved in the direct regulation of glucose metabolism. [from NCI]

MedGen UID:
5827
Concept ID:
C0021641
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
5.

Weight gain

MedGen UID:
881038
Concept ID:
CN236654
Disease or Syndrome
6.

Insulin resistance

Increased resistance towards insulin, that is, diminished effectiveness of insulin in reducing blood glucose levels. [from HPO]

MedGen UID:
504630
Concept ID:
CN000801
Finding
7.

Mutant

An altered form of an individual, organism, population, or genetic character that differs from the corresponding wild type due to one or more alterations (mutations). [from NCI]

MedGen UID:
109303
Concept ID:
C0596988
Cell or Molecular Dysfunction
8.

Peripheral

On or near an edge or constituting an outer boundary; the outer area. (NCI) [from NCI]

MedGen UID:
59959
Concept ID:
C0205100
Spatial Concept
9.

Central

Applies to an abnormality that is located close to the median plane or midline of the body or of the referenced structure. [from HPO]

MedGen UID:
59958
Concept ID:
C0205099
Spatial Concept
10.

Stress

Everyone feels stressed from time to time. Not all stress is bad. All animals have a stress response, and it can be life-saving. But chronic stress can cause both physical and mental harm. There are at least three different types of stress:. -Routine stress related to the pressures of work, family, and other daily responsibilities. -Stress brought about by a sudden negative change, such as losing a job, divorce, or illness. -Traumatic stress, which happens when you are in danger of being seriously hurt or killed. Examples include a major accident, war, assault, or a natural disaster. This type of stress can cause post-traumatic stress disorder (PTSD). Different people may feel stress in different ways. Some people experience digestive symptoms. Others may have headaches, sleeplessness, depressed mood, anger, and irritability. People under chronic stress get more frequent and severe viral infections, such as the flu or common cold. Vaccines, such as the flu shot, are less effective for them. Some people cope with stress more effectively than others. It's important to know your limits when it comes to stress, so you can avoid more serious health effects. NIH: National Institute of Mental Health.  [from MedlinePlus]

MedGen UID:
20971
Concept ID:
C0038435
Finding
11.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
12.

Sequence Deletion

Deletion of sequences of nucleic acids from the genetic material of an individual. [from MeSH]

MedGen UID:
102460
Concept ID:
C0162773
Cell or Molecular Dysfunction
13.

Mutagenesis Process

OBSOLETE. The process by which genetic material undergoes a detectable and heritable structural change. There are three categories of mutation: genome mutations, involving addition or subtraction of one or more whole chromosomes; chromosome mutations, which alter the structure of chromosomes; and gene mutations, where the structure of a gene is altered at the molecular level. [ISBN:0198506732] [from GO]

MedGen UID:
86969
Concept ID:
C0079866
Molecular Function
14.

Leptin

a substance produced by fat cells and involved in the regulation of appetite [from CHV]

MedGen UID:
81112
Concept ID:
C0299583
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
15.

Sugar

A white crystalline carbohydrate, typically sucrose, used as a sweetener and preservative. [from NCI]

MedGen UID:
69157
Concept ID:
C0242209
Carbohydrate; Organic Chemical; Pharmacologic Substance
16.

Polysaccharide

A large carbohydrate molecule. It contains many small sugar molecules that are joined chemically. [from NCI]

MedGen UID:
46014
Concept ID:
C0032594
Carbohydrate; Organic Chemical; Pharmacologic Substance
17.

Opiocortin

MedGen UID:
34046
Concept ID:
C0069575
Hormone; Pharmacologic Substance
18.

Hungry

The desire for FOOD generated by a sensation arising from the lack of food in the STOMACH. [from MeSH]

MedGen UID:
6929
Concept ID:
C0020175
Sign or Symptom
19.

Hormones, Hormone Substitutes, and Hormone Antagonists

A collective grouping for both naturally occurring and synthetic hormones, substitutes, and antagonists. [from MeSH]

MedGen UID:
6887
Concept ID:
C0019934
Pharmacologic Substance
20.

Corticotropin-Releasing Hormone

A hormone synthesized in the hypothalamus and regulates the secretion of adrenocorticotropic hormone (ACTH). [from NCI]

MedGen UID:
3632
Concept ID:
C0010132
Amino Acid, Peptide, or Protein; Hormone; Neuroreactive Substance or Biogenic Amine; Pharmacologic Substance
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