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Neuroendocrine neoplasm

MedGen UID:
64652
Concept ID:
C0206754
Neoplastic Process
Synonyms: Neuroendocrine Tumor; Neuroendocrine Tumors; Tumor, Neuroendocrine; Tumors, Neuroendocrine
SNOMED CT: Neuroendocrine neoplasm (128928004); Neuroendocrine tumor (255046005)
 
HPO: HP:0100634

Definition

Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuroendocrine neoplasm

Conditions with this feature

Prune belly syndrome
MedGen UID:
18718
Concept ID:
C0033770
Disease or Syndrome
In its rare complete form, 'prune belly' syndrome comprises megacystis (massively enlarged bladder) with disorganized detrusor muscle, cryptorchidism, and thin abdominal musculature with overlying lax skin (summary by Weber et al., 2011).

Recent clinical studies

Etiology

Tustumi F, Takeda FR, Uema RH, Pereira GL, Sallum RA, Cecconello I
Arq Gastroenterol 2017 Jan-Mar;54(1):4-10. doi: 10.1590/S0004-2803.2017v54n1-01. PMID: 28079231
Katsuta E, Kudo A, Akashi T, Mitsunori Y, Matsumura S, Aihara A, Ban D, Ochiai T, Tanaka S, Eishi Y, Tanabe M
J Cancer Res Clin Oncol 2016 Jun;142(6):1299-306. Epub 2016 Feb 17 doi: 10.1007/s00432-016-2128-1. PMID: 26885661
Sheng R, Xie Y, Zeng M, Ji Y, Rao S, Chen C
Radiol Med 2015 Nov;120(11):1012-20. Epub 2015 Apr 24 doi: 10.1007/s11547-015-0544-y. PMID: 25907993
Kaemmerer D, Wirtz RM, Fischer EK, Hommann M, Sänger J, Prasad V, Specht E, Baum RP, Schulz S, Lupp A
Pancreas 2015 May;44(4):648-54. doi: 10.1097/MPA.0000000000000316. PMID: 25872131
Paik WH, Ryu JK, Song BJ, Kim J, Park JK, Kim YT, Yoon YB
J Korean Med Sci 2013 May;28(5):750-4. Epub 2013 May 2 doi: 10.3346/jkms.2013.28.5.750. PMID: 23678268Free PMC Article

Diagnosis

Kakkar A, Sharma MC, Yadav R, Panwar R, Mathur SR, Iyer VK, Sahni P
Pathol Res Pract 2016 Aug;212(8):747-50. Epub 2016 Apr 28 doi: 10.1016/j.prp.2016.04.008. PMID: 27161305
Szymanowski B, Duchnowska R, Bilski M, Łapińska G, Hryciuk B, Kamiński G, Szczylik C
Nucl Med Rev Cent East Eur 2016;19(1):54-7. doi: 10.5603/NMR.2016.0011. PMID: 26838946
MacIntosh PW, Jakobiec FA, Stagner AM, Gilani S, Fay A
Surv Ophthalmol 2015 Sep-Oct;60(5):486-94. Epub 2015 Apr 14 doi: 10.1016/j.survophthal.2015.03.002. PMID: 26077631
Sheng R, Xie Y, Zeng M, Ji Y, Rao S, Chen C
Radiol Med 2015 Nov;120(11):1012-20. Epub 2015 Apr 24 doi: 10.1007/s11547-015-0544-y. PMID: 25907993
Paik WH, Ryu JK, Song BJ, Kim J, Park JK, Kim YT, Yoon YB
J Korean Med Sci 2013 May;28(5):750-4. Epub 2013 May 2 doi: 10.3346/jkms.2013.28.5.750. PMID: 23678268Free PMC Article

Therapy

Hörsch D, Ezziddin S, Haug A, Gratz KF, Dunkelmann S, Miederer M, Schreckenberger M, Krause BJ, Bengel FM, Bartenstein P, Biersack HJ, Pöpperl G, Baum RP
Eur J Cancer 2016 May;58:41-51. Epub 2016 Mar 2 doi: 10.1016/j.ejca.2016.01.009. PMID: 26943056
Hooper K, Mukhtar F, Li S, Eltoum IA
Cancer Cytopathol 2013 Nov;121(11):653-60. Epub 2013 Jul 9 doi: 10.1002/cncy.21332. PMID: 23839928
Saxena A, Chua TC, Zhao J, Morris DL
J Surg Oncol 2012 Mar 15;105(4):342-50. Epub 2011 Oct 17 doi: 10.1002/jso.22114. PMID: 22006355
Forslund T, Kellokumpu I, Elomaa E, Arola J, Nuorva K
Clin Nephrol 2011 Feb;75 Suppl 1:42-6. PMID: 21269593
Mitzner LD, Nohria A, Chacho M, Inzucchi SE
Endocr Pract 2000 Sep-Oct;6(5):370-4. doi: 10.4158/EP.6.5.370. PMID: 11141588

Prognosis

Li Y, Dai M, Chang X, Hu W, Chen J, Guo J, Wu W, Zhang T, Liao Q, Liu Z, Hu Y, Zhao Y
Medicine (Baltimore) 2016 Aug;95(34):e4205. doi: 10.1097/MD.0000000000004205. PMID: 27559942Free PMC Article
Sheng R, Xie Y, Zeng M, Ji Y, Rao S, Chen C
Radiol Med 2015 Nov;120(11):1012-20. Epub 2015 Apr 24 doi: 10.1007/s11547-015-0544-y. PMID: 25907993
Wang YH, Yang QC, Lin Y, Xue L, Chen MH, Chen J
Medicine (Baltimore) 2014 Dec;93(27):e247. doi: 10.1097/MD.0000000000000247. PMID: 25501094Free PMC Article
Yang QC, Wang YH, Lin Y, Xue L, Chen YJ, Chen MH, Chen J
Int J Clin Exp Pathol 2014;7(7):4204-12. Epub 2014 Jun 15 PMID: 25120800Free PMC Article
Paik WH, Ryu JK, Song BJ, Kim J, Park JK, Kim YT, Yoon YB
J Korean Med Sci 2013 May;28(5):750-4. Epub 2013 May 2 doi: 10.3346/jkms.2013.28.5.750. PMID: 23678268Free PMC Article

Clinical prediction guides

Sheng R, Xie Y, Zeng M, Ji Y, Rao S, Chen C
Radiol Med 2015 Nov;120(11):1012-20. Epub 2015 Apr 24 doi: 10.1007/s11547-015-0544-y. PMID: 25907993
Kaemmerer D, Wirtz RM, Fischer EK, Hommann M, Sänger J, Prasad V, Specht E, Baum RP, Schulz S, Lupp A
Pancreas 2015 May;44(4):648-54. doi: 10.1097/MPA.0000000000000316. PMID: 25872131
Wang YH, Yang QC, Lin Y, Xue L, Chen MH, Chen J
Medicine (Baltimore) 2014 Dec;93(27):e247. doi: 10.1097/MD.0000000000000247. PMID: 25501094Free PMC Article
Yang QC, Wang YH, Lin Y, Xue L, Chen YJ, Chen MH, Chen J
Int J Clin Exp Pathol 2014;7(7):4204-12. Epub 2014 Jun 15 PMID: 25120800Free PMC Article
Paik WH, Ryu JK, Song BJ, Kim J, Park JK, Kim YT, Yoon YB
J Korean Med Sci 2013 May;28(5):750-4. Epub 2013 May 2 doi: 10.3346/jkms.2013.28.5.750. PMID: 23678268Free PMC Article

Recent systematic reviews

Fields RC, Busam KJ, Chou JF, Panageas KS, Pulitzer MP, Allen PJ, Kraus DH, Brady MS, Coit DG
Cancer 2012 Jul 1;118(13):3311-20. Epub 2011 Nov 9 doi: 10.1002/cncr.26626. PMID: 22072529
Saxena A, Chua TC, Chu F, Al-Zahrani A, Morris DL
Am J Clin Oncol 2012 Oct;35(5):439-45. doi: 10.1097/COC.0b013e31821bc8dd. PMID: 21654315

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