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Items: 15

1.

Sodium selenite

An inorganic form of the trace element selenium with potential antineoplastic activity. Selenium, administered in the form of sodium selenite, is reduced to hydrogen selenide (H2Se) in the presence of glutathione (GSH) and subsequently generates superoxide radicals upon reaction with oxygen. This may inhibit the expression and activity of the transcription factor Sp1; in turn Sp1 down-regulates androgen receptor (AR) expression and blocks AR signaling. Eventually, selenium may induce apoptosis in prostate cancer cells and inhibit tumor cell proliferation. [from NCI]

MedGen UID:
56965
Concept ID:
C0142923
Inorganic Chemical; Pharmacologic Substance
2.

Selenite

MedGen UID:
19922
Concept ID:
C0036580
Inorganic Chemical; Pharmacologic Substance
3.

Frequency

MedGen UID:
91210
Concept ID:
C0376249
Temporal Concept
4.

Selenium

A nonmetallic chemical element found in trace amounts in human body. Selenium primarily occurs in vivo as selenocompounds, mostly selenoproteins such as glutathione peroxidase and thioredoxin reductase (enzymes responsible for detoxification). Alone or in combination with Vitamin E, selenocompounds act as antioxidants. These agents scavenge free radicals; prevent blood clots by inhibiting platelet aggregation; strengthen the immune system; and have been shown, in some instances, to inhibit chromosomal damage and mutations. Exhibiting chemopreventive activity, selenocompounds also inhibit the induction of protein kinase C. [from NCI]

MedGen UID:
48606
Concept ID:
C0036581
Biologically Active Substance; Element, Ion, or Isotope; Pharmacologic Substance
5.

DNA damage

Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis. [from NCI]

MedGen UID:
3880
Concept ID:
C0012860
Cell or Molecular Dysfunction
6.

Strand breaks

MedGen UID:
549441
Concept ID:
C0301647
Molecular Function
7.

Non-progressive

MedGen UID:
375034
Concept ID:
C1842864
8.

Impairment

MedGen UID:
151925
Concept ID:
C0684336
Pathologic Function
9.

Mutant

An altered form of an individual, organism, population, or genetic character that differs from the corresponding wild type due to one or more alterations (mutations). [from NCI]

MedGen UID:
109303
Concept ID:
C0596988
Cell or Molecular Dysfunction
10.

Examined for

Having been subjected to inspection or evaluation. [from NCI]

MedGen UID:
83047
Concept ID:
C0332128
Finding
11.

DNA Breaks

Interruptions in the sugar-phosphate backbone of DNA. [from MeSH]

MedGen UID:
354581
Concept ID:
C1721104
Molecular Function
12.

DNA Double Strand Break

A DNA Double Strand Break involves a disruption of the covalent linkages among the phosphodeoxyribose moieties within the sugar-phosphate backbone in both strands of a DNA molecule. [from NCI]

MedGen UID:
267994
Concept ID:
C1511667
Cell or Molecular Dysfunction
13.

Selenous acid

A selenium compound with the molecular formula H2SO3. It used as a source of SELENIUM, especially for patients that develop selenium deficiency following prolonged PARENTERAL NUTRITION. [from MeSH]

MedGen UID:
78158
Concept ID:
C0074280
Inorganic Chemical; Pharmacologic Substance
14.

Sodium Biselenite

MedGen UID:
443693
Concept ID:
C2828273
Inorganic Chemical; Pharmacologic Substance
15.

Sodium Selenite Pentahydate

MedGen UID:
415781
Concept ID:
C2828274
Inorganic Chemical; Pharmacologic Substance
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