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Leptin

MedGen UID:
81112
Concept ID:
C0299583
Amino Acid, Peptide, or Protein; Hormone; Pharmacologic Substance
Synonyms: Gene Product, Ob; Gene Product, Obese; Ob Gene Product; Ob Protein; Obese Gene Product; Obese Protein
SNOMED CT: Leptin (414601001)
 

Definition

A 16-kDa peptide hormone secreted from WHITE ADIPOCYTES. Leptin serves as a feedback signal from fat cells to the CENTRAL NERVOUS SYSTEM in regulation of food intake, energy balance, and fat storage. [from MeSH]

Recent clinical studies

Etiology

Thagaard IN, Krebs L, Holm JC, Lange T, Larsen T, Christiansen M
Clin Chem Lab Med 2017 Oct 26;55(11):1805-1812. doi: 10.1515/cclm-2017-0427. PMID: 28763297
Sobrinho Santos EM, Guimarães TA, Santos HO, Cangussu LMB, de Jesus SF, Fraga CAC, Cardoso CM, Santos SHS, de Paula AMB, Gomez RS, Guimarães ALS, Farias LC
Tumour Biol 2017 May;39(5):1010428317699130. doi: 10.1177/1010428317699130. PMID: 28459203
Sultana R, Kataki AC, Borthakur BB, Basumatary TK, Bose S
Gene 2017 Jul 20;621:51-58. Epub 2017 Apr 14 doi: 10.1016/j.gene.2017.04.021. PMID: 28414093
Lippi G, Dagostino C, Buonocore R, Aloe R, Bonaguri C, Fanelli G, Allegri M
Clin Chem Lab Med 2017 Aug 28;55(9):1368-1374. doi: 10.1515/cclm-2016-0942. PMID: 28076310
Ida S, Murata K, Kaneko R
J Diabetes 2017 May;9(5):526-535. Epub 2016 Aug 21 doi: 10.1111/1753-0407.12445. PMID: 27380451

Diagnosis

Thagaard IN, Krebs L, Holm JC, Lange T, Larsen T, Christiansen M
Clin Chem Lab Med 2017 Oct 26;55(11):1805-1812. doi: 10.1515/cclm-2017-0427. PMID: 28763297
Nappo A, González-Gil EM, Ahrens W, Bammann K, Michels N, Moreno LA, Kourides Y, Iacoviello L, Mårild S, Fraterman A, Molnàr D, Veidebaum T, Siani A, Russo P
Nutr Metab Cardiovasc Dis 2017 Jun;27(6):543-551. Epub 2017 Apr 19 doi: 10.1016/j.numecd.2017.04.003. PMID: 28511904
Tong X, Ma Y, Zhou Q, He J, Peng B, Liu S, Yan Z, Yang X, Fan H
Oncotarget 2017 Mar 21;8(12):19699-19711. doi: 10.18632/oncotarget.14963. PMID: 28160559Free PMC Article
Lippi G, Dagostino C, Buonocore R, Aloe R, Bonaguri C, Fanelli G, Allegri M
Clin Chem Lab Med 2017 Aug 28;55(9):1368-1374. doi: 10.1515/cclm-2016-0942. PMID: 28076310
Milaneschi Y, Lamers F, Bot M, Drent ML, Penninx BW
Biol Psychiatry 2017 May 1;81(9):807-814. Epub 2015 Nov 17 doi: 10.1016/j.biopsych.2015.10.023. PMID: 26742925

Therapy

Ding X, Kou X, Zhang Y, Zhang X, Cheng G, Jia T
Gene 2017 Oct 30;633:28-34. Epub 2017 Aug 31 doi: 10.1016/j.gene.2017.08.028. PMID: 28864114
Sobrinho Santos EM, Guimarães TA, Santos HO, Cangussu LMB, de Jesus SF, Fraga CAC, Cardoso CM, Santos SHS, de Paula AMB, Gomez RS, Guimarães ALS, Farias LC
Tumour Biol 2017 May;39(5):1010428317699130. doi: 10.1177/1010428317699130. PMID: 28459203
Teixeira TM, da Costa DC, Resende AC, Soulage CO, Bezerra FF, Daleprane JB
J Nutr 2017 Apr;147(4):506-513. Epub 2017 Mar 1 doi: 10.3945/jn.116.239475. PMID: 28250190
Ida S, Murata K, Kaneko R
J Diabetes 2017 May;9(5):526-535. Epub 2016 Aug 21 doi: 10.1111/1753-0407.12445. PMID: 27380451
Mueller NT, Rifas-Shiman SL, Blaser MJ, Gillman MW, Hivert MF
Pediatr Obes 2017 Apr;12(2):129-136. Epub 2016 Mar 7 doi: 10.1111/ijpo.12119. PMID: 26948966Free PMC Article

Prognosis

Thagaard IN, Krebs L, Holm JC, Lange T, Larsen T, Christiansen M
Clin Chem Lab Med 2017 Oct 26;55(11):1805-1812. doi: 10.1515/cclm-2017-0427. PMID: 28763297
Tong X, Ma Y, Zhou Q, He J, Peng B, Liu S, Yan Z, Yang X, Fan H
Oncotarget 2017 Mar 21;8(12):19699-19711. doi: 10.18632/oncotarget.14963. PMID: 28160559Free PMC Article
Anar C, Deniz D, Erol S, Batum O, Bicmen C, Yilmaz U
Bratisl Lek Listy 2017;118(1):13-16. doi: 10.4149/BLL_2017_003. PMID: 28127977
Lippi G, Dagostino C, Buonocore R, Aloe R, Bonaguri C, Fanelli G, Allegri M
Clin Chem Lab Med 2017 Aug 28;55(9):1368-1374. doi: 10.1515/cclm-2016-0942. PMID: 28076310
Tariq S, Baig M, Tariq S, Shahzad M
Gynecol Endocrinol 2017 Apr;33(4):287-291. Epub 2016 Dec 23 doi: 10.1080/09513590.2016.1261103. PMID: 28010139

Clinical prediction guides

Ding X, Kou X, Zhang Y, Zhang X, Cheng G, Jia T
Gene 2017 Oct 30;633:28-34. Epub 2017 Aug 31 doi: 10.1016/j.gene.2017.08.028. PMID: 28864114
Thagaard IN, Krebs L, Holm JC, Lange T, Larsen T, Christiansen M
Clin Chem Lab Med 2017 Oct 26;55(11):1805-1812. doi: 10.1515/cclm-2017-0427. PMID: 28763297
Nappo A, González-Gil EM, Ahrens W, Bammann K, Michels N, Moreno LA, Kourides Y, Iacoviello L, Mårild S, Fraterman A, Molnàr D, Veidebaum T, Siani A, Russo P
Nutr Metab Cardiovasc Dis 2017 Jun;27(6):543-551. Epub 2017 Apr 19 doi: 10.1016/j.numecd.2017.04.003. PMID: 28511904
Lippi G, Dagostino C, Buonocore R, Aloe R, Bonaguri C, Fanelli G, Allegri M
Clin Chem Lab Med 2017 Aug 28;55(9):1368-1374. doi: 10.1515/cclm-2016-0942. PMID: 28076310
Mueller NT, Rifas-Shiman SL, Blaser MJ, Gillman MW, Hivert MF
Pediatr Obes 2017 Apr;12(2):129-136. Epub 2016 Mar 7 doi: 10.1111/ijpo.12119. PMID: 26948966Free PMC Article

Recent systematic reviews

Rostás I, Pótó L, Mátrai P, Hegyi P, Tenk J, Garami A, Illés A, Solymár M, Pétervári E, Szűcs Á, Párniczky A, Pécsi D, Rumbus Z, Zsiborás C, Füredi N, Balaskó M
PLoS One 2017;12(8):e0182801. Epub 2017 Aug 15 doi: 10.1371/journal.pone.0182801. PMID: 28809927Free PMC Article
Tong X, Ma Y, Zhou Q, He J, Peng B, Liu S, Yan Z, Yang X, Fan H
Oncotarget 2017 Mar 21;8(12):19699-19711. doi: 10.18632/oncotarget.14963. PMID: 28160559Free PMC Article
Zheng SH, Du DF, Li XL
Reprod Sci 2017 May;24(5):656-670. Epub 2016 Oct 26 doi: 10.1177/1933719116670265. PMID: 27798245
Ida S, Murata K, Kaneko R
J Diabetes 2017 May;9(5):526-535. Epub 2016 Aug 21 doi: 10.1111/1753-0407.12445. PMID: 27380451
Lee YH, Bae SC
Z Rheumatol 2016 Dec;75(10):1021-1027. doi: 10.1007/s00393-016-0050-1. PMID: 26820722

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