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Items: 20

1.

Uridine

A nucleoside consisting of uracil and D-ribose and a component of RNA. Uridine has been studied as a rescue agent to reduce the toxicities associated with 5-fluorouracil (5-FU), thereby allowing the administration of higher doses of 5-FU in chemotherapy regimens. (NCI04) [from NCI]

MedGen UID:
22572
Concept ID:
C0041984
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
2.

UPREG

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. [from MeSH]

MedGen UID:
12003
Concept ID:
C0041904
Molecular Function
3.

Phosphorylation

The creation of a phosphate derivative of an organic molecule. This is usually achieved by transferring a phosphate group from ATP via the action of a kinase. [from NCI]

MedGen UID:
10742
Concept ID:
C0031715
Molecular Function
4.

Adenosine preparation

A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. [from MeSH]

MedGen UID:
127
Concept ID:
C0001443
Biologically Active Substance; Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
5.

Ionophore

Chemical agents that increase the permeability of biological or artificial lipid membranes to specific ions. Most ionophores are relatively small organic molecules that act as mobile carriers within membranes or coalesce to form ion permeable channels across membranes. Many are antibiotics, and many act as uncoupling agents by short-circuiting the proton gradient across mitochondrial membranes. [from MeSH]

MedGen UID:
5888
Concept ID:
C0022022
Pharmacologic Substance
6.

Mitogen

A soluble substance, usually a protein, that induces mitosis in resting cells, thereby causing cell proliferation. [from NCI]

MedGen UID:
7665
Concept ID:
C0026249
Pharmacologic Substance
7.

Diamide

A sulfhydryl reagent which oxidizes sulfhydryl groups to the disulfide form. It is a radiation-sensitizing agent of anoxic bacterial and mammalian cells. [from MeSH]

MedGen UID:
3797
Concept ID:
C0011953
Indicator, Reagent, or Diagnostic Aid; Organic Chemical; Pharmacologic Substance
8.

Calcium

A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. [from MeSH]

MedGen UID:
710
Concept ID:
C0006675
Biologically Active Substance; Element, Ion, or Isotope; Pharmacologic Substance
9.

Rapidly involuting congenital hemangioma

MedGen UID:
698687
Concept ID:
C1275421
Neoplastic Process
10.

Acetate compound

Salt or ester form of acetic acid. Acetate is the most common building block for biosynthesis, such as fatty acids. [from NCI]

MedGen UID:
452099
Concept ID:
C0000975
Organic Chemical; Pharmacologic Substance
11.

Post-Translational Regulation

Post-Translational Regulation is controlled biochemical alteration of proteins involving generally reversible covalent modification or irreversible processing to regulate activity, location, or stability. [from NCI]

MedGen UID:
307998
Concept ID:
C1514251
Molecular Function
12.

Genetic translation

Protein synthesis is the group of processes that are involved in generation of mature protein molecules. Although protein synthesis may involve translation alone in many cases, in others, it involves also protein folding, integration of prosthetic groups, glycosylation, methylation, phosphorylation, lipidation and any other process that may be involved in maturation of the polypeptide to the biologically active form. [from NCI]

MedGen UID:
108933
Concept ID:
C0597295
Molecular Function
13.

Peripheral

On or near an edge or constituting an outer boundary; the outer area. [from NCI]

MedGen UID:
59959
Concept ID:
C0205100
Spatial Concept
14.

Post-Translational Modification

The enzymatic processing of a polypeptide chain after translation from messenger RNA and after peptide bond formation has occurred. Examples include glycosylation, acylation, limited proteolysis, phosphorylation, isoprenylation.(On-line Medical Dictionary) [from NCI]

MedGen UID:
46159
Concept ID:
C0033666
Molecular Function
15.

Adenoscan

MedGen UID:
810650
Concept ID:
C0718262
Organic Chemical; Pharmacologic Substance
16.

Membrane Transport Modulators

Agents that affect ION PUMPS; ION CHANNELS; ABC TRANSPORTERS; and other MEMBRANE TRANSPORT PROTEINS. [from MeSH]

MedGen UID:
288786
Concept ID:
C1563710
Pharmacologic Substance
17.

Biosynthesis, Peptide

The production of PEPTIDES or PROTEINS by the constituents of a living organism. The biosynthesis of proteins on RIBOSOMES following an RNA template is termed translation (TRANSLATION, GENETIC). There are other, non-ribosomal peptide biosynthesis (PEPTIDE BIOSYNTHESIS, NUCLEIC ACID-INDEPENDENT) mechanisms carried out by PEPTIDE SYNTHASES and PEPTIDYLTRANSFERASES. Further modifications of peptide chains yield functional peptide and protein molecules. [from MeSH]

MedGen UID:
272130
Concept ID:
C1327133
Molecular Function
18.

Tetradecanoylphorbol Acetate

A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. (NCI04) [from NCI]

MedGen UID:
21493
Concept ID:
C0039654
Hazardous or Poisonous Substance; Organic Chemical; Pharmacologic Substance
19.

Purine nucleoside

Purines with a RIBOSE attached that can be phosphorylated to PURINE NUCLEOTIDES. [from MeSH]

MedGen UID:
18775
Concept ID:
C0034136
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
20.

Oxidation-reduction

A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471). [from MeSH]

MedGen UID:
18243
Concept ID:
C0030012
Molecular Function
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