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Items: 11

1.

Venous Thromboembolism

Occlusion of the lumen of a vein by a thrombus that has migrated from a distal site via the blood stream. [from NCI]

MedGen UID:
348285
Concept ID:
C1861172
Disease or Syndrome
2.

Heparin

A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts. [from MeSH]

MedGen UID:
42413
Concept ID:
C0019134
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
3.

Thromboembolism

Obstruction of a blood vessel (embolism) by a blood clot (THROMBUS) in the blood stream. [from MeSH]

MedGen UID:
21532
Concept ID:
C0040038
Finding; Pathologic Function
4.

Pregnancy

The state or condition of having a developing embryo or fetus in the body (uterus), after union of an ovum and spermatozoon, during the period from conception to birth. [from NCI]

MedGen UID:
10895
Concept ID:
C0032961
Organism Function
5.

Thromboembolism

The formation of a blood clot inside a blood vessel that subsequently travels through the blood stream from the site where it formed to another location in the body, generally leading to vascular occlusion at the distant site. [from HPO]

MedGen UID:
505000
Concept ID:
CN001725
Finding
6.

Thrombophilia

Prothrombin-related thrombophilia is characterized by venous thromboembolism (VTE) manifest most commonly in adults as deep-vein thrombosis (DVT) in the legs or pulmonary embolism. The clinical expression of prothrombin-related thrombophilia is variable; many individuals heterozygous or homozygous for the 20210G>A (G20210A or c.*97G>A) allele in F2 never develop thrombosis, and while most heterozygotes who develop thrombotic complications remain asymptomatic until adulthood, some have recurrent thromboembolism before age 30 years. The relative risk for DVT in adults heterozygous for the 20210G>A allele is two- to fivefold increased; in children, the relative risk for thrombosis is three- to fourfold increased. 20210G>A heterozygosity has at most a modest effect on recurrence risk after a first episode. Although prothrombin-related thrombophilia may increase the risk for pregnancy loss, its association with preeclampsia and other complications of pregnancy such as intrauterine growth restriction and placental abruption remains controversial. Factors that predispose to thrombosis in prothrombin-related thrombophilia include: the number of 20210G>A alleles; presence of coexisting genetic abnormalities including factor V Leiden; and acquired thrombophilic disorders (e.g., antiphospholipid antibodies). Circumstantial risk factors for thrombosis include pregnancy and oral contraceptive use. Some evidence suggests that the risk for VTE in 20210G>A heterozygotes increases after travel. [from GTR]

MedGen UID:
98306
Concept ID:
C0398623
Disease or Syndrome
7.

Low molecular weight heparin

Heparin fractions with a molecular weight usually between 4000 and 6000 kD. These low-molecular-weight fractions are effective antithrombotic agents. Their administration reduces the risk of hemorrhage, they have a longer half-life, and their platelet interactions are reduced in comparison to unfractionated heparin. They also provide an effective prophylaxis against postoperative major pulmonary embolism. [from MeSH]

MedGen UID:
42415
Concept ID:
C0019139
Organic Chemical; Pharmacologic Substance
8.

FR-860

MedGen UID:
196579
Concept ID:
C0733844
Organic Chemical; Pharmacologic Substance
9.

Fragmin

MedGen UID:
182406
Concept ID:
C0917726
Organic Chemical; Pharmacologic Substance
10.

Kabi-2165

MedGen UID:
149208
Concept ID:
C0733845
Organic Chemical; Pharmacologic Substance
11.

Dalteparin

A low molecular weight, synthetic heparin. As an anticoagulant/antithrombotic agent, dalteparin binds to antithrombin and enhances the inhibition of Factor Xa. Compared to unfractionated heparins, the use of dalteparin is associated with lower incidences of osteoporosis and heparin-induced thrombocytopenia. (NCI04) [from NCI]

MedGen UID:
64593
Concept ID:
C0206461
Organic Chemical; Pharmacologic Substance
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