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Items: 1 to 20 of 34

1.

Nonalcoholic steatohepatitis

Fatty replacement and damage to the hepatocytes not related to alcohol use. It may lead to cirrhosis and liver failure. [from NCI]

MedGen UID:
469032
Concept ID:
C3241937
Disease or Syndrome
2.

Hepatic steatosis

MedGen UID:
398225
Concept ID:
C2711227
Disease or Syndrome
3.

Oxidative Stress

A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products. The damage to biological tissues is caused by superoxide and other free radicals generated by many factors, including exposure to alcohol, medications, trauma, cold, toxins, and radiation or by antimicrobial cellular immunity, metabolic abnormality, or "normal" aging; not synonymous with hypoxia or hyperoxia. Oxidative stress promotes a range of degenerative disorders, including cancer, diabetes, premature aging, Alzheimer's, and many others. [from NCI]

MedGen UID:
66929
Concept ID:
C0242606
Cell or Molecular Dysfunction
4.

Fatty liver

Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS. [from MeSH]

MedGen UID:
41974
Concept ID:
C0015695
Disease or Syndrome
5.

Nitric oxide

A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP. [from MeSH]

MedGen UID:
14378
Concept ID:
C0028128
Biologically Active Substance; Inorganic Chemical; Pharmacologic Substance
6.

Methionine preparation

A sulfur-containing essential L-amino acid that is important in many body functions. [from MeSH]

MedGen UID:
9989
Concept ID:
C0025646
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
7.

Inflammation

MedGen UID:
7072
Concept ID:
C0021368
Pathologic Function
8.

Choline

A basic constituent of lecithin that is found in many plants and animal organs. It is important as a precursor of acetylcholine, as a methyl donor in various metabolic processes, and in lipid metabolism. [from MeSH]

MedGen UID:
3048
Concept ID:
C0008405
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
9.

Multicentric plasma cell variant of Castleman disease

MedGen UID:
762089
Concept ID:
C3541461
Finding
10.

Microvesicular hepatic steatosis

MedGen UID:
376784
Concept ID:
C1850415
Finding
11.

Malformation of cortical development

MedGen UID:
364975
Concept ID:
C1955869
Disease or Syndrome
12.

Macular corneal dystrophy Type I

Macular corneal dystrophy (MCD) is an autosomal recessive disorder in which progressive punctate opacities in the cornea result in bilateral loss of vision, eventually necessitating corneal transplantation. MCD is classified into 2 subtypes, type I and type II, defined by the respective absence and presence of sulfated keratan sulfate in the patient serum, although both types have clinically indistinguishable phenotypes (summary by Akama et al., 2000). [from OMIM]

MedGen UID:
351514
Concept ID:
C1636149
Disease or Syndrome
13.

Multicentric Angiofollicular Lymphoid Hyperplasia

A form of angiofollicular lymphoid hyperplasia characterized by fever, generalized lymphadenopathy, hypergammaglobulinemia, and dysfunction of multiple organs. Other signs and symptoms include anemia, thrombocytopenia, hepatomegaly, peripheral neuropathy and pleural effusions. Morphologically, in the majority of cases the lymph nodes show features of angiofollicular lymphoid hyperplasia of the plasma cell type. In a minority of cases, changes of angiofollicular lymphoid hyperplasia of the hyaline-vascular type are seen. In contrast to patients with localized disease who are usually cured following resection of the lesion, patients with the multicentric form of the disease may follow a progressive clinical course, complicated by infection, Kaposi sarcoma, or lymphoma. [from NCI]

MedGen UID:
233197
Concept ID:
C1334815
Neoplastic Process
14.

Impairment

MedGen UID:
151925
Concept ID:
C0684336
Pathologic Function
15.

Non-alcoholic fatty liver

A term referring to fatty replacement of the hepatic parenchyma which is not related to alcohol use. [from NCI]

MedGen UID:
96033
Concept ID:
C0400966
Disease or Syndrome
16.

Oncolysis

The destruction of tumor cells or a reduction in swelling. [from NCI]

MedGen UID:
90709
Concept ID:
C0333516
Neoplastic Process
17.

Fatty degeneration

A morphologic finding indicating intracytoplasmic fat accumulation in the liver parenchyma. [from NCI]

MedGen UID:
57759
Concept ID:
C0152254
Pathologic Function
18.

Risk factor

An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, on the basis of epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. [from MeSH]

MedGen UID:
48477
Concept ID:
C0035648
Finding
19.

Oxidized glutathione

A GLUTATHIONE dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized. [from MeSH]

MedGen UID:
29640
Concept ID:
C0061516
Amino Acid, Peptide, or Protein; Pharmacologic Substance
20.

Stress

The negative mental, emotional, and physical reactions that occur when environmental stressors are perceived as exceeding the individual's adaptive capacities. [from NCI]

MedGen UID:
20971
Concept ID:
C0038435
Finding
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