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Antioxidants

MedGen UID:
1608
Concept ID:
C0003402
Pharmacologic Substance
Synonyms: Antioxidant
 

Definition

Antioxidants are man-made or natural substances that may prevent or delay some types of cell damage. Antioxidants are found in many foods, including fruits and vegetables. They are also available as dietary supplements. Examples of antioxidants include. - Beta-carotene . - Lutein . - Lycopene. - Selenium. - Vitamin A. - Vitamin C. - Vitamin E. Vegetables and fruits are rich sources of antioxidants. There is good evidence that eating a diet with lots of vegetables and fruits is healthy and lowers risks of certain diseases. But it isn't clear whether this is because of the antioxidants, something else in the foods, or other factors. High-dose supplements of antioxidants may be linked to health risks in some cases. For example, high doses of beta-carotene may increase the risk of lung cancer in smokers. High doses of vitamin E may increase risks of prostate cancer and one type of stroke. Antioxidant supplements may also interact with some medicines. To minimize risk, tell you of your health care providers about any antioxidants you use. NIH: National Center for Complementary and Integrative Health.  [from MedlinePlus]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAntioxidants

Recent clinical studies

Etiology

Chowdhury MI, Hasan M, Islam MS, Sarwar MS, Amin MN, Uddin SMN, Rahaman MZ, Banik S, Hussain MS, Yokota K, Hasnat A
J Trace Elem Med Biol 2017 Jan;39:162-168. Epub 2016 Oct 1 doi: 10.1016/j.jtemb.2016.09.012. PMID: 27908410
Rodgers A, Mokoena M, Durbach I, Lazarus J, de Jager S, Ackermann H, Breytenbach I, Okada A, Usami M, Hirose Y, Ando R, Yasui T, Kohri K
Urolithiasis 2016 Aug;44(4):299-310. Epub 2015 Dec 31 doi: 10.1007/s00240-015-0855-4. PMID: 26721697
Mumford SL, Browne RW, Schliep KC, Schmelzer J, Plowden TC, Michels KA, Sjaarda LA, Zarek SM, Perkins NJ, Messer LC, Radin RG, Wactawski-Wende J, Schisterman EF
J Nutr 2016 Jan;146(1):98-106. Epub 2015 Nov 18 doi: 10.3945/jn.115.217620. PMID: 26581679Free PMC Article
Lovat C, Nassar AM, Kubow S, Li XQ, Donnelly DJ
Crit Rev Food Sci Nutr 2016 Oct 25;56(14):2278-303. doi: 10.1080/10408398.2013.830208. PMID: 25674927
Pérez-Jiménez J, Díaz-Rubio ME, Saura-Calixto F
Plant Foods Hum Nutr 2015 Dec;70(4):365-70. doi: 10.1007/s11130-015-0513-6. PMID: 26482738

Diagnosis

Ma L, Shi H, Lian K, Diao Y, Chen Y, Ma C, Kang W
Food Chem 2017 Mar 1;218:422-426. Epub 2016 Sep 7 doi: 10.1016/j.foodchem.2016.09.025. PMID: 27719930
Martínez-Las Heras R, Pinazo A, Heredia A, Andrés A
Food Chem 2017 Jan 1;214:478-85. Epub 2016 Jul 18 doi: 10.1016/j.foodchem.2016.07.104. PMID: 27507501
Lam V, Hackett M, Takechi R
Nutrients 2016 Dec 20;8(12) doi: 10.3390/nu8120828. PMID: 27999412Free PMC Article
Moori M, Ghafoori H, Sariri R
Lupus 2016 Mar;25(3):265-71. Epub 2015 Oct 7 doi: 10.1177/0961203315605368. PMID: 26449364
Vucinovic Z, Duplancic D, Seselja-Perisin A, Kukoc-Modun L, Gunjaca G, Radman M, Vukovic J, Tsikas D, Poljak K, Modun D
Clin Physiol Funct Imaging 2015 Jan;35(1):76-80. Epub 2014 May 25 doi: 10.1111/cpf.12169. PMID: 24863414

Therapy

Hannan PA, Khan JA, Ullah I, Ullah S
Lipids Health Dis 2016 Sep 9;15:151. doi: 10.1186/s12944-016-0323-3. PMID: 27613388Free PMC Article
Rodgers A, Mokoena M, Durbach I, Lazarus J, de Jager S, Ackermann H, Breytenbach I, Okada A, Usami M, Hirose Y, Ando R, Yasui T, Kohri K
Urolithiasis 2016 Aug;44(4):299-310. Epub 2015 Dec 31 doi: 10.1007/s00240-015-0855-4. PMID: 26721697
Sack CS, Jansen KL, Cosselman KE, Trenga CA, Stapleton PL, Allen J, Peretz A, Olives C, Kaufman JD
Am J Respir Crit Care Med 2016 May 1;193(9):1000-7. doi: 10.1164/rccm.201506-1247OC. PMID: 26599707Free PMC Article
Mumford SL, Browne RW, Schliep KC, Schmelzer J, Plowden TC, Michels KA, Sjaarda LA, Zarek SM, Perkins NJ, Messer LC, Radin RG, Wactawski-Wende J, Schisterman EF
J Nutr 2016 Jan;146(1):98-106. Epub 2015 Nov 18 doi: 10.3945/jn.115.217620. PMID: 26581679Free PMC Article
Sandhir R, Yadav A, Sunkaria A, Singhal N
Neurochem Int 2015 Oct;89:209-26. Epub 2015 Aug 24 doi: 10.1016/j.neuint.2015.08.011. PMID: 26315960

Prognosis

Shalimar, Midha S, Hasan A, Dhingra R, Garg PK
J Gastroenterol Hepatol 2017 Jan;32(1):270-277. doi: 10.1111/jgh.13410. PMID: 27061119
Moori M, Ghafoori H, Sariri R
Lupus 2016 Mar;25(3):265-71. Epub 2015 Oct 7 doi: 10.1177/0961203315605368. PMID: 26449364
Chen L, Meng K, Su W, Fu Y
Cell Biochem Biophys 2015 Nov;73(2):473-478. doi: 10.1007/s12013-015-0681-x. PMID: 27352341
Schmidt HH, Stocker R, Vollbracht C, Paulsen G, Riley D, Daiber A, Cuadrado A
Antioxid Redox Signal 2015 Nov 10;23(14):1130-43. Epub 2015 Aug 31 doi: 10.1089/ars.2015.6393. PMID: 26154592Free PMC Article
Heyland DK, Elke G, Cook D, Berger MM, Wischmeyer PE, Albert M, Muscedere J, Jones G, Day AG; Canadian Critical Care Trials Group.
JPEN J Parenter Enteral Nutr 2015 May;39(4):401-9. Epub 2014 May 5 doi: 10.1177/0148607114529994. PMID: 24803474

Clinical prediction guides

Hannan PA, Khan JA, Ullah I, Ullah S
Lipids Health Dis 2016 Sep 9;15:151. doi: 10.1186/s12944-016-0323-3. PMID: 27613388Free PMC Article
Radomska-Leśniewska DM, Hevelke A, Skopiński P, Bałan B, Jóźwiak J, Rokicki D, Skopińska-Różewska E, Białoszewska A
Pharmacol Rep 2016 Apr;68(2):462-71. Epub 2015 Oct 23 doi: 10.1016/j.pharep.2015.10.002. PMID: 26922554
Sack CS, Jansen KL, Cosselman KE, Trenga CA, Stapleton PL, Allen J, Peretz A, Olives C, Kaufman JD
Am J Respir Crit Care Med 2016 May 1;193(9):1000-7. doi: 10.1164/rccm.201506-1247OC. PMID: 26599707Free PMC Article
Pérez-Jiménez J, Díaz-Rubio ME, Saura-Calixto F
Plant Foods Hum Nutr 2015 Dec;70(4):365-70. doi: 10.1007/s11130-015-0513-6. PMID: 26482738
Durand E, Zhao Y, Coupland JN, Elias RJ
J Agric Food Chem 2015 Dec 16;63(49):10655-61. Epub 2015 Dec 1 doi: 10.1021/acs.jafc.5b04152. PMID: 26479322

Recent systematic reviews

Tavanai E, Mohammadkhani G
Eur Arch Otorhinolaryngol 2017 Apr;274(4):1821-1834. Epub 2016 Nov 17 doi: 10.1007/s00405-016-4378-6. PMID: 27858145
Roleira FM, Tavares-da-Silva EJ, Varela CL, Costa SC, Silva T, Garrido J, Borges F
Food Chem 2015 Sep 15;183:235-58. Epub 2015 Mar 18 doi: 10.1016/j.foodchem.2015.03.039. PMID: 25863633
van Zanten AR
Curr Opin Clin Nutr Metab Care 2015 Mar;18(2):179-86. doi: 10.1097/MCO.0000000000000152. PMID: 25590616
Heyland DK, Elke G, Cook D, Berger MM, Wischmeyer PE, Albert M, Muscedere J, Jones G, Day AG; Canadian Critical Care Trials Group.
JPEN J Parenter Enteral Nutr 2015 May;39(4):401-9. Epub 2014 May 5 doi: 10.1177/0148607114529994. PMID: 24803474
Ahmed Ali U, Jens S, Busch OR, Keus F, van Goor H, Gooszen HG, Boermeester MA
Cochrane Database Syst Rev 2014 Aug 21;(8):CD008945. doi: 10.1002/14651858.CD008945.pub2. PMID: 25144441

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