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Caffeine

MedGen UID:
2403
Concept ID:
C0006644
Organic Chemical; Pharmacologic Substance
Synonyms: 1,3,7-Trimethylxanthine; 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-
SNOMED CT: Caffeine (91107009); Caffeine (255641001)
 

Definition

Caffeine is a bitter substance found in coffee, tea, soft drinks, chocolate, kola nuts, and certain medicines. It has many effects on the body's metabolism, including stimulating the central nervous system. This can make you more alert and give you a boost of energy. . For most people, the amount of caffeine in two to four cups of coffee a day is not harmful. However, too much caffeine can cause problems. It can. -Make you jittery and shaky. -Make it hard to fall asleep or stay asleep. -Cause headaches or dizziness. -Make your heart beat faster or cause abnormal heart rhythms. -Cause dehydration. -Make you dependent on it so you need to take more of it. If you stop using caffeine, you could get withdrawal symptoms. Some people are more sensitive to the effects of caffeine than others. They should limit their use of caffeine. So should pregnant and nursing women. Certain drugs and supplements may interact with caffeine. If you have questions about whether caffeine is safe for you, talk with your health care provider. Food and Drug Administration.  [from MedlinePlus]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCaffeine

Recent clinical studies

Etiology

Simon DK, Wu C, Tilley BC, Lohmann K, Klein C, Payami H, Wills AM, Aminoff MJ, Bainbridge J, Dewey R, Hauser RA, Schaake S, Schneider JS, Sharma S, Singer C, Tanner CM, Truong D, Wei P, Wong PS, Yang T
J Neurol Sci 2017 Apr 15;375:355-359. Epub 2017 Feb 17 doi: 10.1016/j.jns.2017.02.032. PMID: 28320167Free PMC Article
Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Hoffman RM
Anticancer Res 2017 Mar;37(3):1005-1011. doi: 10.21873/anticanres.11410. PMID: 28314258
Malaviya AN
Clin Rheumatol 2017 Feb;36(2):279-285. Epub 2016 Sep 6 doi: 10.1007/s10067-016-3398-3. PMID: 27596742
Köksal E, Yardımcı H, Kocaadam B, Deniz Güneş B, Yılmaz B, Karabudak E
Int J Food Sci Nutr 2017 Mar;68(2):227-233. Epub 2016 Sep 2 doi: 10.1080/09637486.2016.1226276. PMID: 27589213
Lee MJ, Choi HA, Choi H, Chung CS
J Headache Pain 2016 Dec;17(1):71. Epub 2016 Aug 5 doi: 10.1186/s10194-016-0662-5. PMID: 27492448Free PMC Article

Diagnosis

Chen F, Hu ZY, Parker RB, Laizure SC
Biomed Chromatogr 2017 Jun;31(6) Epub 2017 Jan 4 doi: 10.1002/bmc.3900. PMID: 27864843Free PMC Article
Köksal E, Yardımcı H, Kocaadam B, Deniz Güneş B, Yılmaz B, Karabudak E
Int J Food Sci Nutr 2017 Mar;68(2):227-233. Epub 2016 Sep 2 doi: 10.1080/09637486.2016.1226276. PMID: 27589213
Scurachio RS, Mattiucci F, Santos WG, Skibsted LH, Cardoso DR
J Photochem Photobiol B 2016 Oct;163:277-83. Epub 2016 Aug 27 doi: 10.1016/j.jphotobiol.2016.08.042. PMID: 27611451
Kuijpers D, Prakken NH, Vliegenthart R, van Dijkman PR, van der Harst P, Oudkerk M
Int J Cardiovasc Imaging 2016 Oct;32(10):1545-53. Epub 2016 Jul 29 doi: 10.1007/s10554-016-0949-2. PMID: 27473274Free PMC Article
Alansari K, Toaimah FH, Khalafalla H, El Tatawy LA, Davidson BL, Ahmed W
J Pediatr 2016 Oct;177:204-211.e3. Epub 2016 May 14 doi: 10.1016/j.jpeds.2016.04.060. PMID: 27189681

Therapy

Simon DK, Wu C, Tilley BC, Lohmann K, Klein C, Payami H, Wills AM, Aminoff MJ, Bainbridge J, Dewey R, Hauser RA, Schaake S, Schneider JS, Sharma S, Singer C, Tanner CM, Truong D, Wei P, Wong PS, Yang T
J Neurol Sci 2017 Apr 15;375:355-359. Epub 2017 Feb 17 doi: 10.1016/j.jns.2017.02.032. PMID: 28320167Free PMC Article
Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Hoffman RM
Anticancer Res 2017 Mar;37(3):1005-1011. doi: 10.21873/anticanres.11410. PMID: 28314258
Vandenberghe C, St-Pierre V, Courchesne-Loyer A, Hennebelle M, Castellano CA, Cunnane SC
Can J Physiol Pharmacol 2017 Apr;95(4):455-458. Epub 2016 Nov 25 doi: 10.1139/cjpp-2016-0338. PMID: 28177691
Malaviya AN
Clin Rheumatol 2017 Feb;36(2):279-285. Epub 2016 Sep 6 doi: 10.1007/s10067-016-3398-3. PMID: 27596742
Köksal E, Yardımcı H, Kocaadam B, Deniz Güneş B, Yılmaz B, Karabudak E
Int J Food Sci Nutr 2017 Mar;68(2):227-233. Epub 2016 Sep 2 doi: 10.1080/09637486.2016.1226276. PMID: 27589213

Prognosis

Malaviya AN
Clin Rheumatol 2017 Feb;36(2):279-285. Epub 2016 Sep 6 doi: 10.1007/s10067-016-3398-3. PMID: 27596742
Lee MJ, Choi HA, Choi H, Chung CS
J Headache Pain 2016 Dec;17(1):71. Epub 2016 Aug 5 doi: 10.1186/s10194-016-0662-5. PMID: 27492448Free PMC Article
Kuijpers D, Prakken NH, Vliegenthart R, van Dijkman PR, van der Harst P, Oudkerk M
Int J Cardiovasc Imaging 2016 Oct;32(10):1545-53. Epub 2016 Jul 29 doi: 10.1007/s10554-016-0949-2. PMID: 27473274Free PMC Article
Rhee JJ, Qin F, Hedlin HK, Chang TI, Bird CE, Zaslavsky O, Manson JE, Stefanick ML, Winkelmayer WC
Am J Clin Nutr 2016 Jan;103(1):210-7. Epub 2015 Dec 9 doi: 10.3945/ajcn.115.120147. PMID: 26657046Free PMC Article
Park HW, Lim G, Chung SH, Chung S, Kim KS, Kim SN
J Korean Med Sci 2015 Dec;30(12):1828-35. Epub 2015 Nov 30 doi: 10.3346/jkms.2015.30.12.1828. PMID: 26713059Free PMC Article

Clinical prediction guides

Igarashi K, Kawaguchi K, Kiyuna T, Murakami T, Yamamoto N, Hayashi K, Kimura H, Miwa S, Tsuchiya H, Hoffman RM
Anticancer Res 2017 Mar;37(3):1005-1011. doi: 10.21873/anticanres.11410. PMID: 28314258
Kouchi H, Uppari N, Joseph V, Bairam A
Respir Physiol Neurobiol 2017 Jun;240:8-16. Epub 2017 Feb 16 doi: 10.1016/j.resp.2017.01.014. PMID: 28215596
Giles GE, Mahoney CR, Brunyé TT, Taylor HA, Kanarek RB
Can J Physiol Pharmacol 2017 Jan;95(1):93-100. doi: 10.1139/cjpp-2016-0498. PMID: 28044450
Köksal E, Yardımcı H, Kocaadam B, Deniz Güneş B, Yılmaz B, Karabudak E
Int J Food Sci Nutr 2017 Mar;68(2):227-233. Epub 2016 Sep 2 doi: 10.1080/09637486.2016.1226276. PMID: 27589213
Lee MJ, Choi HA, Choi H, Chung CS
J Headache Pain 2016 Dec;17(1):71. Epub 2016 Aug 5 doi: 10.1186/s10194-016-0662-5. PMID: 27492448Free PMC Article

Recent systematic reviews

Robinson D, Hanna-Mitchell A, Rantell A, Thiagamoorthy G, Cardozo L
Neurourol Urodyn 2017 Apr;36(4):876-881. doi: 10.1002/nau.23149. PMID: 28444711
Cao H, Ren J, Feng X, Yang G, Liu J
Syst Rev 2016 Mar 15;5:45. doi: 10.1186/s13643-016-0221-9. PMID: 26979845Free PMC Article
Zulli A, Smith RM, Kubatka P, Novak J, Uehara Y, Loftus H, Qaradakhi T, Pohanka M, Kobyliak N, Zagatina A, Klimas J, Hayes A, La Rocca G, Soucek M, Kruzliak P
Eur J Nutr 2016 Jun;55(4):1331-43. Epub 2016 Mar 1 doi: 10.1007/s00394-016-1179-z. PMID: 26932503
Wang L, Shen X, Wu Y, Zhang D
Aust N Z J Psychiatry 2016 Mar;50(3):228-42. Epub 2015 Sep 2 doi: 10.1177/0004867415603131. PMID: 26339067
Chen LW, Wu Y, Neelakantan N, Chong MF, Pan A, van Dam RM
Public Health Nutr 2016 May;19(7):1233-44. Epub 2015 Sep 2 doi: 10.1017/S1368980015002463. PMID: 26329421

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