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Inflammation

MedGen UID:
7072
Concept ID:
C0021368
Pathologic Function
Synonyms: Inflammations
SNOMED CT: Inflammation (257552002); Inflammation (23583003); Inflammatory reaction (23583003)
 

Definition

A localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInflammation

Recent clinical studies

Etiology

Hove-Skovsgaard M, Gaardbo JC, Kolte L, Winding K, Seljeflot I, Svardal A, Berge RK, Gerstoft J, Ullum H, Trøseid M, Nielsen SD
BMC Infect Dis 2017 Mar 29;17(1):234. doi: 10.1186/s12879-017-2334-8. PMID: 28356058Free PMC Article
Wang C, Ha X, Li W, Xu P, Gu Y, Wang T, Wang Y, Xie J, Zhang J
Inflammation 2017 Feb;40(1):42-51. doi: 10.1007/s10753-016-0450-z. PMID: 27714571
Karakus E, Halici Z, Albayrak A, Bayir Y, Demirci E, Aydin A, Ozturk-Karagoz B, Cadirci E, Ayan AK, Sahin A, Unal D
Inflammation 2016 Feb;39(1):336-346. doi: 10.1007/s10753-015-0254-6. PMID: 26412256
Mo XM, Sun HX
Inflammation 2015;38(3):1374-83. doi: 10.1007/s10753-015-0109-1. PMID: 25676435
Qian X, Yin T, Li T, Kang C, Guo R, Sun B, Liu C
Inflammation 2012 Aug;35(4):1507-11. doi: 10.1007/s10753-012-9464-3. PMID: 22527145

Diagnosis

Leroy S, Caumette E, Waddington C, Hébert A, Brant R, Lavoie PM
J Pediatr 2018 Jan;192:60-65.e1. Epub 2017 Oct 31 doi: 10.1016/j.jpeds.2017.09.011. PMID: 29092751
Lennard K, Dabee S, Barnabas SL, Havyarimana E, Blakney A, Jaumdally SZ, Botha G, Mkhize NN, Bekker LG, Lewis DA, Gray G, Mulder N, Passmore JS, Jaspan HB
Infect Immun 2018 Jan;86(1) Epub 2017 Dec 19 doi: 10.1128/IAI.00410-17. PMID: 29038128Free PMC Article
Hove-Skovsgaard M, Gaardbo JC, Kolte L, Winding K, Seljeflot I, Svardal A, Berge RK, Gerstoft J, Ullum H, Trøseid M, Nielsen SD
BMC Infect Dis 2017 Mar 29;17(1):234. doi: 10.1186/s12879-017-2334-8. PMID: 28356058Free PMC Article
Adabimohazab R, Garfinkel A, Milam EC, Frosch O, Mangone A, Convit A
Inflammation 2016 Jun;39(3):994-1003. doi: 10.1007/s10753-016-0329-z. PMID: 26956471Free PMC Article
Qian X, Yin T, Li T, Kang C, Guo R, Sun B, Liu C
Inflammation 2012 Aug;35(4):1507-11. doi: 10.1007/s10753-012-9464-3. PMID: 22527145

Therapy

Phosri S, Jangpromma N, Patramanon R, Kongyingyoes B, Mahakunakorn P, Klaynongsruang S
Inflammation 2017 Feb;40(1):205-220. doi: 10.1007/s10753-016-0471-7. PMID: 27838796
Kariminik A, Dabiri S, Yaghobi R
Inflammation 2016 Aug;39(4):1514-9. doi: 10.1007/s10753-016-0385-4. PMID: 27277862
Adabimohazab R, Garfinkel A, Milam EC, Frosch O, Mangone A, Convit A
Inflammation 2016 Jun;39(3):994-1003. doi: 10.1007/s10753-016-0329-z. PMID: 26956471Free PMC Article
Ku SK, Kwak S, Bae JS
Inflammation 2014 Dec;37(6):2164-73. doi: 10.1007/s10753-014-9950-x. PMID: 24950780
Holfeld J, Tepeköylü C, Kozaryn R, Urbschat A, Zacharowski K, Grimm M, Paulus P
Inflammation 2014 Feb;37(1):65-70. doi: 10.1007/s10753-013-9712-1. PMID: 23948864

Prognosis

Leroy S, Caumette E, Waddington C, Hébert A, Brant R, Lavoie PM
J Pediatr 2018 Jan;192:60-65.e1. Epub 2017 Oct 31 doi: 10.1016/j.jpeds.2017.09.011. PMID: 29092751
Lennard K, Dabee S, Barnabas SL, Havyarimana E, Blakney A, Jaumdally SZ, Botha G, Mkhize NN, Bekker LG, Lewis DA, Gray G, Mulder N, Passmore JS, Jaspan HB
Infect Immun 2018 Jan;86(1) Epub 2017 Dec 19 doi: 10.1128/IAI.00410-17. PMID: 29038128Free PMC Article
Meirow Y, Baniyash M
Cancer Immunol Immunother 2017 Aug;66(8):1089-1101. Epub 2017 Jul 3 doi: 10.1007/s00262-017-2035-6. PMID: 28674756
Lazzerini PE, Laghi-Pasini F, Bertolozzi I, Morozzi G, Lorenzini S, Simpatico A, Selvi E, Bacarelli MR, Finizola F, Vanni F, Lazaro D, Aromolaran A, El Sherif N, Boutjdir M, Capecchi PL
Heart 2017 Nov;103(22):1821-1829. Epub 2017 May 10 doi: 10.1136/heartjnl-2016-311079. PMID: 28490617
Adabimohazab R, Garfinkel A, Milam EC, Frosch O, Mangone A, Convit A
Inflammation 2016 Jun;39(3):994-1003. doi: 10.1007/s10753-016-0329-z. PMID: 26956471Free PMC Article

Clinical prediction guides

Leroy S, Caumette E, Waddington C, Hébert A, Brant R, Lavoie PM
J Pediatr 2018 Jan;192:60-65.e1. Epub 2017 Oct 31 doi: 10.1016/j.jpeds.2017.09.011. PMID: 29092751
Lennard K, Dabee S, Barnabas SL, Havyarimana E, Blakney A, Jaumdally SZ, Botha G, Mkhize NN, Bekker LG, Lewis DA, Gray G, Mulder N, Passmore JS, Jaspan HB
Infect Immun 2018 Jan;86(1) Epub 2017 Dec 19 doi: 10.1128/IAI.00410-17. PMID: 29038128Free PMC Article
Chao C, Richdale K, Jalbert I, Doung K, Gokhale M
Cont Lens Anterior Eye 2017 Oct;40(5):273-282. Epub 2017 Jun 9 doi: 10.1016/j.clae.2017.05.008. PMID: 28602547
Lazzerini PE, Laghi-Pasini F, Bertolozzi I, Morozzi G, Lorenzini S, Simpatico A, Selvi E, Bacarelli MR, Finizola F, Vanni F, Lazaro D, Aromolaran A, El Sherif N, Boutjdir M, Capecchi PL
Heart 2017 Nov;103(22):1821-1829. Epub 2017 May 10 doi: 10.1136/heartjnl-2016-311079. PMID: 28490617
Adabimohazab R, Garfinkel A, Milam EC, Frosch O, Mangone A, Convit A
Inflammation 2016 Jun;39(3):994-1003. doi: 10.1007/s10753-016-0329-z. PMID: 26956471Free PMC Article

Recent systematic reviews

Namaste SM, Rohner F, Huang J, Bhushan NL, Flores-Ayala R, Kupka R, Mei Z, Rawat R, Williams AM, Raiten DJ, Northrop-Clewes CA, Suchdev PS
Am J Clin Nutr 2017 Jul;106(Suppl 1):359S-371S. Epub 2017 Jun 14 doi: 10.3945/ajcn.116.141762. PMID: 28615259Free PMC Article
Namaste SM, Aaron GJ, Varadhan R, Peerson JM, Suchdev PS; BRINDA Working Group.
Am J Clin Nutr 2017 Jul;106(Suppl 1):333S-347S. Epub 2017 Jun 14 doi: 10.3945/ajcn.116.142273. PMID: 28615254Free PMC Article
Larson LM, Namaste SM, Williams AM, Engle-Stone R, Addo OY, Suchdev PS, Wirth JP, Temple V, Serdula M, Northrop-Clewes CA
Am J Clin Nutr 2017 Jul;106(Suppl 1):390S-401S. Epub 2017 Jun 14 doi: 10.3945/ajcn.116.142166. PMID: 28615251Free PMC Article
Bollen J, Trick L, Llewellyn D, Dickens C
J Psychosom Res 2017 Mar;94:47-55. Epub 2017 Jan 4 doi: 10.1016/j.jpsychores.2017.01.002. PMID: 28183402
Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, Tanaka T, Colicino E, Waite LL, Joehanes R, Guan W, Brody JA, Elks C, Marioni R, Jhun MA, Agha G, Bressler J, Ward-Caviness CK, Chen BH, Huan T, Bakulski K, Salfati EL; WHI-EMPC Investigators., Fiorito G; CHARGE epigenetics of Coronary Heart Disease., Wahl S, Schramm K, Sha J, Hernandez DG, Just AC, Smith JA, Sotoodehnia N, Pilling LC, Pankow JS, Tsao PS, Liu C, Zhao W, Guarrera S, Michopoulos VJ, Smith AK, Peters MJ, Melzer D, Vokonas P, Fornage M, Prokisch H, Bis JC, Chu AY, Herder C, Grallert H, Yao C, Shah S, McRae AF, Lin H, Horvath S, Fallin D, Hofman A, Wareham NJ, Wiggins KL, Feinberg AP, Starr JM, Visscher PM, Murabito JM, Kardia SL, Absher DM, Binder EB, Singleton AB, Bandinelli S, Peters A, Waldenberger M, Matullo G, Schwartz JD, Demerath EW, Uitterlinden AG, van Meurs JB, Franco OH, Chen YI, Levy D, Turner ST, Deary IJ, Ressler KJ, Dupuis J, Ferrucci L, Ong KK, Assimes TL, Boerwinkle E, Koenig W, Arnett DK, Baccarelli AA, Benjamin EJ, Dehghan A
Genome Biol 2016 Dec 12;17(1):255. doi: 10.1186/s13059-016-1119-5. PMID: 27955697Free PMC Article

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