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Personality disorder

MedGen UID:
45827
Concept ID:
C0031212
Mental or Behavioral Dysfunction
Synonyms: Personality Disorder; Personality Disorders
SNOMED CT: Personality disorder (33449004)
 
HPO: HP:0012075

Definition

Personality disorders are a group of mental illnesses. They involve long-term patterns of thoughts and behaviors that are unhealthy and inflexible. The behaviors cause serious problems with relationships and work. People with personality disorders have trouble dealing with everyday stresses and problems. They often have stormy relationships with other people. The cause of personality disorders is unknown. However, genes and childhood experiences may play a role. The symptoms of each personality disorder are different. They can mild or severe. People with personality disorders may have trouble realizing that they have a problem. To them, their thoughts are normal, and they often blame others for their problems. They may try to get help because of their problems with relationships and work. Treatment usually includes talk therapy and sometimes medicine.  [from MedlinePlus]

Conditions with this feature

Homocystinuria due to CBS deficiency
MedGen UID:
461694
Concept ID:
C3150344
Disease or Syndrome
Homocystinuria caused by cystathionine ß-synthase (CBS) deficiency is characterized by involvement of the eye (ectopia lentis and/or severe myopia), skeletal system (excessive height, long limbs, scolioisis, and pectus excavatum), vascular system (thromboembolism), and CNS (developmental delay/intellectual disability). All four ? or only one ? of the systems can be involved; expressivity is variable for all of the clinical signs. It is not unusual for a previously asymptomatic individual to present in adult years with only a thromboembolic event that is often cerebrovascular. Two phenotypic variants are recognized, B6-responsive homocystinuria and B6-non-responsive homocystinuria. B6-responsive homocystinuria is usually milder than the non-responsive variant. Thromboembolism is the major cause of early death and morbidity. IQ in individuals with untreated homocystinuria ranges widely, from 10 to 138. In B6-responsive individuals the mean IQ is 79 versus 57 for those who are B6-non-responsive. Other features that may occur include: seizures, psychiatric problems, extrapyramidal signs (e.g., dystonia), hypopigmentation of the skin and hair, malar flush, livedo reticularis, and pancreatitis.
Epilepsy, nocturnal frontal lobe, 5
MedGen UID:
767220
Concept ID:
C3554306
Disease or Syndrome
Nocturnal frontal lobe epilepsy-5 is an autosomal dominant focal epilepsy syndrome characterized by childhood onset of clusters of motor seizures during sleep. Some patients may develop behavioral or psychiatric manifestations and/or intellectual disability. The phenotype is more severe than observed in other genetic forms of ENFL (summary by Heron et al., 2012). For a general description and a discussion of genetic heterogeneity of ENFL, see ENFL1 (600513).

Recent clinical studies

Etiology

Dickens GL, Lamont E, Gray S
J Clin Nurs 2016 Jul;25(13-14):1848-75. Epub 2016 May 3 doi: 10.1111/jocn.13202. PMID: 27139693
Merrett Z, Rossell SL, Castle DJ
Aust N Z J Psychiatry 2016 Jul;50(7):640-8. Epub 2016 Feb 24 doi: 10.1177/0004867416632595. PMID: 26912339
Zanarini MC, Frankenburg FR, Reich DB, Fitzmaurice GM
Am J Psychiatry 2016 Jul 1;173(7):688-94. Epub 2016 Feb 12 doi: 10.1176/appi.ajp.2015.15081045. PMID: 26869248Free PMC Article
Blankley G, Galbally M, Snellen M, Power J, Lewis AJ
Australas Psychiatry 2015 Dec;23(6):688-92. Epub 2015 Jun 30 doi: 10.1177/1039856215590254. PMID: 26133812
Yelland C, Girke T, Tottman C, Williams AS
Australas Psychiatry 2015 Dec;23(6):683-7. Epub 2015 Jun 11 doi: 10.1177/1039856215590251. PMID: 26070637

Diagnosis

Dickens GL, Lamont E, Gray S
J Clin Nurs 2016 Jul;25(13-14):1848-75. Epub 2016 May 3 doi: 10.1111/jocn.13202. PMID: 27139693
Beatson J, Broadbear JH, Sivakumaran H, George K, Kotler E, Moss F, Rao S
Aust N Z J Psychiatry 2016 Dec;50(12):1139-1145. Epub 2016 Apr 7 doi: 10.1177/0004867416640100. PMID: 27056175
Merrett Z, Rossell SL, Castle DJ
Aust N Z J Psychiatry 2016 Jul;50(7):640-8. Epub 2016 Feb 24 doi: 10.1177/0004867416632595. PMID: 26912339
Blankley G, Galbally M, Snellen M, Power J, Lewis AJ
Australas Psychiatry 2015 Dec;23(6):688-92. Epub 2015 Jun 30 doi: 10.1177/1039856215590254. PMID: 26133812
Yelland C, Girke T, Tottman C, Williams AS
Australas Psychiatry 2015 Dec;23(6):683-7. Epub 2015 Jun 11 doi: 10.1177/1039856215590251. PMID: 26070637

Therapy

Feliu-Soler A, Pascual JC, Elices M, Martín-Blanco A, Carmona C, Cebolla A, Simón V, Soler J
Clin Psychol Psychother 2017 Jan;24(1):278-286. Epub 2016 Jan 28 doi: 10.1002/cpp.2000. PMID: 26818533
Chanen A, Jackson H, Cotton SM, Gleeson J, Davey CG, Betts J, Reid S, Thompson K, McCutcheon L
Trials 2015 Oct 21;16:476. doi: 10.1186/s13063-015-1001-x. PMID: 26489661Free PMC Article
Ayodeji E, Green J, Roberts C, Trainor G, Rothwell J, Woodham A, Wood A
Br J Psychiatry 2015 Oct;207(4):313-9. Epub 2015 Aug 6 doi: 10.1192/bjp.bp.113.138941. PMID: 26250743
Crawford MJ, Sanatinia R, Barrett B, Byford S, Cunningham G, Gakhal K, Lawrence-Smith G, Leeson V, Lemonsky F, Lykomitrou G, Montgomery A, Morriss R, Paton C, Tan W, Tyrer P, Reilly JG
Trials 2015 Jul 18;16:308. doi: 10.1186/s13063-015-0823-x. PMID: 26187496Free PMC Article
Dubovsky AN, Kiefer MM
Med Clin North Am 2014 Sep;98(5):1049-64. doi: 10.1016/j.mcna.2014.06.005. PMID: 25134872

Prognosis

Lee RJ, Fanning JR, Coccaro EF
J Psychiatr Res 2016 May;76:38-43. Epub 2015 Dec 23 doi: 10.1016/j.jpsychires.2015.11.009. PMID: 26874268
Zanarini MC, Frankenburg FR, Reich DB, Fitzmaurice GM
Am J Psychiatry 2016 Jul 1;173(7):688-94. Epub 2016 Feb 12 doi: 10.1176/appi.ajp.2015.15081045. PMID: 26869248Free PMC Article
Ayodeji E, Green J, Roberts C, Trainor G, Rothwell J, Woodham A, Wood A
Br J Psychiatry 2015 Oct;207(4):313-9. Epub 2015 Aug 6 doi: 10.1192/bjp.bp.113.138941. PMID: 26250743
Yelland C, Girke T, Tottman C, Williams AS
Australas Psychiatry 2015 Dec;23(6):683-7. Epub 2015 Jun 11 doi: 10.1177/1039856215590251. PMID: 26070637
Yang M, Mamy J, Zhou L, Liao YH, Wang Q, Seewoobudul V, Xiao SY, Hao W
Addict Behav 2014 Mar;39(3):573-9. Epub 2013 Nov 10 doi: 10.1016/j.addbeh.2013.11.003. PMID: 24342175

Clinical prediction guides

Dickens GL, Lamont E, Gray S
J Clin Nurs 2016 Jul;25(13-14):1848-75. Epub 2016 May 3 doi: 10.1111/jocn.13202. PMID: 27139693
Outcalt J, Dimaggio G, Popolo R, Buck K, Chaudoin-Patzoldt KA, Kukla M, Olesek KL, Lysaker PH
Compr Psychiatry 2016 Jan;64:22-8. Epub 2015 Oct 22 doi: 10.1016/j.comppsych.2015.10.002. PMID: 26541558
Koerting J, Pukrop R, Klein P, Ritter K, Knowles M, Banzhaf A, Gentschow L, Vater A, Heuser I, Colla M, Roepke S
J Atten Disord 2016 Aug;20(8):715-24. Epub 2012 Nov 27 doi: 10.1177/1087054712464391. PMID: 23190611
Richman MJ, Unoka Z
Br J Psychiatry 2015 Dec;207(6):483-9. doi: 10.1192/bjp.bp.114.152108. PMID: 26628692
Blankley G, Galbally M, Snellen M, Power J, Lewis AJ
Australas Psychiatry 2015 Dec;23(6):688-92. Epub 2015 Jun 30 doi: 10.1177/1039856215590254. PMID: 26133812

Recent systematic reviews

Dickens GL, Lamont E, Gray S
J Clin Nurs 2016 Jul;25(13-14):1848-75. Epub 2016 May 3 doi: 10.1111/jocn.13202. PMID: 27139693
Beatson J, Broadbear JH, Sivakumaran H, George K, Kotler E, Moss F, Rao S
Aust N Z J Psychiatry 2016 Dec;50(12):1139-1145. Epub 2016 Apr 7 doi: 10.1177/0004867416640100. PMID: 27056175
Merrett Z, Rossell SL, Castle DJ
Aust N Z J Psychiatry 2016 Jul;50(7):640-8. Epub 2016 Feb 24 doi: 10.1177/0004867416632595. PMID: 26912339
Dickens GL, Hallett N, Lamont E
Int J Nurs Stud 2016 Apr;56:114-27. Epub 2015 Dec 19 doi: 10.1016/j.ijnurstu.2015.10.019. PMID: 26747180
Richman MJ, Unoka Z
Br J Psychiatry 2015 Dec;207(6):483-9. doi: 10.1192/bjp.bp.114.152108. PMID: 26628692

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