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nipple discharge

MedGen UID:
56200
Concept ID:
C0149741
Sign or Symptom
Synonyms: Discharge, Nipple; Discharges, Nipple; Nipple Discharge; Nipple Discharges
SNOMED CT: Nipple discharge symptom (162164007); Discharge from nipple (54302000); Observation of nipple discharge (54302000); Breast discharge (54302000)
 

Definition

Fluid that seeps out of one or both nipples of the breast. [from MeSH]

Recent clinical studies

Etiology

Wong Chung JE, Jeuriens-van de Ven SA, van Helmond N, Wauters CA, Duijm LE, Strobbe LJ
Breast J 2016 Mar-Apr;22(2):202-8. Epub 2016 Jan 22 doi: 10.1111/tbj.12544. PMID: 26799061
Makita M, Akiyama F, Gomi N, Iwase T
Breast Cancer 2016 Mar;23(2):242-51. Epub 2014 Aug 24 doi: 10.1007/s12282-014-0561-z. PMID: 25150843
Zhao S, Gai X, Wang Y, Liang W, Gao H, Zhang K, Wang H, Liu Y, Wang J, Ma R
Chin J Physiol 2015 Dec 31;58(6):385-92. doi: 10.4077/CJP.2015.BAD336. PMID: 26717917
Bahl M, Baker JA, Greenup RA, Ghate SV
AJR Am J Roentgenol 2015 Jul;205(1):203-8. doi: 10.2214/AJR.14.13354. PMID: 26102400
Yang X, Li H, Gou J, Tan Q, Wang L, Lin X, Feng X, Jiang Y, Zhang S, Lv Q
Breast J 2014 Jul-Aug;20(4):388-93. doi: 10.1111/tbj.12275. PMID: 24985528

Diagnosis

Waaijer L, Simons JM, Borel Rinkes IH, van Diest PJ, Verkooijen HM, Witkamp AJ
Br J Surg 2016 May;103(6):632-643. Epub 2016 Mar 23 doi: 10.1002/bjs.10125. PMID: 27004588
Wong Chung JE, Jeuriens-van de Ven SA, van Helmond N, Wauters CA, Duijm LE, Strobbe LJ
Breast J 2016 Mar-Apr;22(2):202-8. Epub 2016 Jan 22 doi: 10.1111/tbj.12544. PMID: 26799061
Makita M, Akiyama F, Gomi N, Iwase T
Breast Cancer 2016 Mar;23(2):242-51. Epub 2014 Aug 24 doi: 10.1007/s12282-014-0561-z. PMID: 25150843
Zhao S, Gai X, Wang Y, Liang W, Gao H, Zhang K, Wang H, Liu Y, Wang J, Ma R
Chin J Physiol 2015 Dec 31;58(6):385-92. doi: 10.4077/CJP.2015.BAD336. PMID: 26717917
Patel BK, Falcon S, Drukteinis J
Am J Med 2015 Apr;128(4):353-60. Epub 2014 Oct 17 doi: 10.1016/j.amjmed.2014.09.031. PMID: 25447625

Therapy

Wong Chung JE, Jeuriens-van de Ven SA, van Helmond N, Wauters CA, Duijm LE, Strobbe LJ
Breast J 2016 Mar-Apr;22(2):202-8. Epub 2016 Jan 22 doi: 10.1111/tbj.12544. PMID: 26799061
Johnson-Smith A, Omondi LW, Gaillard D, Smith A
Pediatr Nurs 2015 Jan-Feb;41(1):48-9. PMID: 26281276
Yang X, Li H, Gou J, Tan Q, Wang L, Lin X, Feng X, Jiang Y, Zhang S, Lv Q
Breast J 2014 Jul-Aug;20(4):388-93. doi: 10.1111/tbj.12275. PMID: 24985528
Ramirez-Hernandez IE, Hardman RL, Kirkpatrick AD, Sutcliffe J
J Radiol Case Rep 2013 May;7(5):16-22. Epub 2013 May 1 doi: 10.3941/jrcr.v7i5.1229. PMID: 23705053Free PMC Article
Cabioglu N, Krishnamurthy S, Kuerer HM, Hunt KK, Singletary SE, Meric-Bernstam F, Ross MI, Feig BW, Ames FC, Babiera GV
Cancer 2004 Aug 1;101(3):508-17. doi: 10.1002/cncr.20394. PMID: 15274063

Prognosis

Wong Chung JE, Jeuriens-van de Ven SA, van Helmond N, Wauters CA, Duijm LE, Strobbe LJ
Breast J 2016 Mar-Apr;22(2):202-8. Epub 2016 Jan 22 doi: 10.1111/tbj.12544. PMID: 26799061
Makita M, Akiyama F, Gomi N, Iwase T
Breast Cancer 2016 Mar;23(2):242-51. Epub 2014 Aug 24 doi: 10.1007/s12282-014-0561-z. PMID: 25150843
Bahl M, Baker JA, Greenup RA, Ghate SV
AJR Am J Roentgenol 2015 Jul;205(1):203-8. doi: 10.2214/AJR.14.13354. PMID: 26102400
Yang X, Li H, Gou J, Tan Q, Wang L, Lin X, Feng X, Jiang Y, Zhang S, Lv Q
Breast J 2014 Jul-Aug;20(4):388-93. doi: 10.1111/tbj.12275. PMID: 24985528
Wang G, Qin Y, Zhang J, Zhao J, Liang Y, Zhang Z, Qin M, Sun Y
Int J Mol Sci 2014 May 28;15(6):9546-65. doi: 10.3390/ijms15069546. PMID: 24879526Free PMC Article

Clinical prediction guides

Wong Chung JE, Jeuriens-van de Ven SA, van Helmond N, Wauters CA, Duijm LE, Strobbe LJ
Breast J 2016 Mar-Apr;22(2):202-8. Epub 2016 Jan 22 doi: 10.1111/tbj.12544. PMID: 26799061
Makita M, Akiyama F, Gomi N, Iwase T
Breast Cancer 2016 Mar;23(2):242-51. Epub 2014 Aug 24 doi: 10.1007/s12282-014-0561-z. PMID: 25150843
Bahl M, Baker JA, Greenup RA, Ghate SV
AJR Am J Roentgenol 2015 Jul;205(1):203-8. doi: 10.2214/AJR.14.13354. PMID: 26102400
Yang X, Li H, Gou J, Tan Q, Wang L, Lin X, Feng X, Jiang Y, Zhang S, Lv Q
Breast J 2014 Jul-Aug;20(4):388-93. doi: 10.1111/tbj.12275. PMID: 24985528
Wang G, Qin Y, Zhang J, Zhao J, Liang Y, Zhang Z, Qin M, Sun Y
Int J Mol Sci 2014 May 28;15(6):9546-65. doi: 10.3390/ijms15069546. PMID: 24879526Free PMC Article

Recent systematic reviews

Waaijer L, Simons JM, Borel Rinkes IH, van Diest PJ, Verkooijen HM, Witkamp AJ
Br J Surg 2016 May;103(6):632-643. Epub 2016 Mar 23 doi: 10.1002/bjs.10125. PMID: 27004588
Lavoué V, Fritel X, Antoine M, Beltjens F, Bendifallah S, Boisserie-Lacroix M, Boulanger L, Canlorbe G, Catteau-Jonard S, Chabbert-Buffet N, Chamming's F, Chéreau E, Chopier J, Coutant C, Demetz J, Guilhen N, Fauvet R, Kerdraon O, Laas E, Legendre G, Mathelin C, Nadeau C, Naggara IT, Ngô C, Ouldamer L, Rafii A, Roedlich MN, Seror J, Séror JY, Touboul C, Uzan C, Daraï E; French College of Gynecologists and Obstetricians (CNGOF).
Eur J Obstet Gynecol Reprod Biol 2016 May;200:16-23. Epub 2016 Feb 28 doi: 10.1016/j.ejogrb.2016.02.017. PMID: 26967341
Acer T, Derbent M, Hiçsönmez A
J Pediatr Surg 2015 Nov;50(11):1975-82. Epub 2015 Sep 3 doi: 10.1016/j.jpedsurg.2015.08.049. PMID: 26410727
Galvin R, Joyce D, Downey E, Boland F, Fahey T, Hill AK
BMC Cancer 2014 Oct 3;14:743. doi: 10.1186/1471-2407-14-743. PMID: 25277332Free PMC Article
Chen L, Zhou WB, Zhao Y, Liu XA, Ding Q, Zha XM, Wang S
Breast Cancer Res Treat 2012 Feb;132(1):9-14. Epub 2011 Sep 27 doi: 10.1007/s10549-011-1787-5. PMID: 21947751

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