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1.

Tyrosine

A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin. [from MeSH]

MedGen UID:
21746
Concept ID:
C0041485
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
2.

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. [from HPO]

MedGen UID:
9725
Concept ID:
C0023418
Neoplastic Process
3.

Acute lymphoblastic leukemia

A form of acute leukemia characterized by excess lympoblasts. [from HPO]

MedGen UID:
505958
Concept ID:
CN005851
Finding
4.

B Acute Lymphoblastic Leukemia

The most frequent type of acute lymphoblastic leukemia. Approximately 75% of cases occur in children under six years of age. This is a good prognosis leukemia. In the pediatric age group the complete remission rate is approximately 95% and the disease free survival rate is 70%. Approximately 80% of children appear to be cured. In the adult age group the complete remission rate is 60-85%. (WHO, 2001) [from NCI]

MedGen UID:
226949
Concept ID:
C1292769
Neoplastic Process
5.

Acute lymphoid leukemia

Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL (Trevino et al., 2009). Genetic Heterogeneity of Acute Lymphoblastic Leukemia A susceptibility locus for acute lymphoblastic leukemia (ALL1) has been mapped to chromosome 10q21. See also ALL2 (613067), which has been mapped to chromosome 7p12.2; and ALL3 (615545), which is caused by mutation in the PAX5 gene (167414) on chromosome 9p. [from GTR]

MedGen UID:
7317
Concept ID:
C0023449
Neoplastic Process
6.

Malignancies

MedGen UID:
924235
Concept ID:
C4282132
Neoplastic Process
7.

Therapy-Related Neoplasm

The development of a neoplasm in response to medical or surgical treatment, induced by the treatment itself. [from NCI]

MedGen UID:
88608
Concept ID:
C0086696
Neoplastic Process
8.

Infertility

A reduced or absent capacity to reproduce. [from MeSH]

MedGen UID:
43876
Concept ID:
C0021359
Finding; Pathologic Function
9.

Leukemia, acute lymphoblastic, susceptibility to, 3

MedGen UID:
816204
Concept ID:
C3809874
Neoplastic Process
10.

Infertility

MedGen UID:
504598
Concept ID:
CN000737
Finding
11.

Unlikely

Having little chance of being the case or of coming about. [from NCI]

MedGen UID:
152899
Concept ID:
C0750558
Finding
12.

Severe

Having a high degree of severity. For quantitative traits, a deviation of between four and five standard deviations from the appropriate population mean. [from HPO]

MedGen UID:
104640
Concept ID:
C0205082
Qualitative Concept
13.

Onset

The age group in which disease manifestations appear. [from HPO]

MedGen UID:
64519
Concept ID:
C0206132
Quantitative Concept
14.

Acute

Sudden appearance of disease manifestations over a short period of time. [from HPO]

MedGen UID:
61381
Concept ID:
C0205178
Temporal Concept
15.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
16.

Precursor Cell Lymphoblastic Leukemia-Lymphoma

A neoplasm characterized by abnormalities of the lymphoid cell precursors leading to excessive lymphoblasts in the marrow and other organs. It is the most common cancer in children and accounts for the vast majority of all childhood leukemias. [from MeSH]

MedGen UID:
409528
Concept ID:
C1961102
Neoplastic Process
17.

Lymphatism

MedGen UID:
141817
Concept ID:
C0524631
Disease or Syndrome
18.

Pre-B Acute Lymphoblastic Leukemia

An acute lymphoblastic leukemia that originates from pre-B lymphocytes. The pre-B lymphoblasts contain cytoplasmic immunoglobulin. [from NCI]

MedGen UID:
44126
Concept ID:
C0023485
Neoplastic Process
19.

L1 Acute Lymphoblastic Leukemia

An acute lymphoblastic leukemia (current term: precursor lymphoblastic leukemia) of B-or T-cell origin which according to the FAB classification is characterized by the presence of more mature-appearing lymphoblasts. [from NCI]

MedGen UID:
44122
Concept ID:
C0023452
Neoplastic Process
20.

Neoplasms by Histologic Type

A collective term for the various histological types of NEOPLASMS. It is more likely to be used by searchers than by indexers and catalogers. [from MeSH]

MedGen UID:
10295
Concept ID:
C0027652
Neoplastic Process
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