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Infection by Trypanosoma cruzi

MedGen UID:
11935
Concept ID:
C0041234
Disease or Syndrome
Synonyms: American Trypanosomiasis; Chagas Disease; Chagas' Disease; Disease, Chagas; Disease, Chagas'; South American Trypanosomiasis; Trypanosomiasis, American; Trypanosomiasis, South American
Modes of inheritance:
not inherited
MedGen UID:
832438
Concept ID:
CN227390
Intellectual Product
Source: Orphanet
Describes a disorder that is not inherited.
not inherited (Orphanet)
SNOMED CT: Infection by Trypanosoma cruzi (77506005); American trypanosomiasis (77506005); Chagas' disease (77506005); South American trypanosomiasis (77506005); Infection caused by Trypanosoma cruzi (77506005); Chagas-Mazza disease (77506005)
 
Orphanet: ORPHA3386

Definition

Chagas disease is caused by a parasite. It is common in Latin America but not in the United States. Infected blood-sucking bugs, sometimes called kissing bugs, spread it. When the bug bites you, usually on your face, it leaves behind infected waste. You can get the infection if you rub it in your eyes or nose, the bite wound or a cut. The disease can also spread through contaminated food, a blood transfusion, a donated organ or from mother to baby during pregnancy. If you notice symptoms, they might include. - Fever. - Flu-like symptoms. - A rash. - A swollen eyelid. These early symptoms usually go away. However, if you don't treat the infection, it stays in your body. Later, it can cause serious intestinal and heart problems. A physical exam and blood tests can diagnose it. You may also need tests to see whether the disease has affected your intestines and heart. Medicines can kill the parasite, especially early on. You can also treat related problems. For example, a pacemaker helps with certain heart complications. Centers for Disease Control and Prevention.  [from MedlinePlus]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInfection by Trypanosoma cruzi
Follow this link to review classifications for Infection by Trypanosoma cruzi in Orphanet.

Recent clinical studies

Etiology

Colantonio LD, Prado N, Segura EL, Sosa-Estani S
PLoS Negl Trop Dis 2016 May;10(5):e0004651. Epub 2016 May 9 doi: 10.1371/journal.pntd.0004651. PMID: 27158908Free PMC Article
Maeda FY, Clemente TM, Macedo S, Cortez C, Yoshida N
Parasit Vectors 2016 Apr 1;9:189. doi: 10.1186/s13071-016-1455-z. PMID: 27038796Free PMC Article
Péneau J, Nguyen A, Flores-Ferrer A, Blanchet D, Gourbière S
PLoS Negl Trop Dis 2016 Feb;10(2):e0004427. Epub 2016 Feb 11 doi: 10.1371/journal.pntd.0004427. PMID: 26867025Free PMC Article
Castro-Sesquen YE, Gilman RH, Yauri V, Angulo N, Verastegui M, Velásquez DE, Sterling CR, Martin D, Bern C
Am J Pathol 2011 Jul;179(1):281-8. Epub 2011 May 14 doi: 10.1016/j.ajpath.2011.03.043. PMID: 21703410Free PMC Article
Levi GC, Lobo IM, Kallás EG, Amato Neto V
Rev Inst Med Trop Sao Paulo 1996 Jan-Feb;38(1):35-8. PMID: 8762637

Diagnosis

Zulantay I, Corral G, Guzman MC, Aldunate F, Guerra W, Cruz I, Araya A, Tapia V, Marquez F, Muñoz C, Apt W
Ann Trop Med Parasitol 2011 Mar;105(2):123-8. doi: 10.1179/136485911X12899838413583. PMID: 21396248Free PMC Article
Kinoshita-Yanaga AT, Toledo MJ, Araújo SM, Vier BP, Gomes ML
Rev Inst Med Trop Sao Paulo 2009 Sep-Oct;51(5):295-8. PMID: 19893984
Cortez M, Neira I, Ferreira D, Luquetti AO, Rassi A, Atayde VD, Yoshida N
Infect Immun 2003 Nov;71(11):6184-91. PMID: 14573635Free PMC Article
Gallo P, Fabião Neto OM, Suarez JM, Borba RP
Arq Neuropsiquiatr 1992 Sep;50(3):375-7. PMID: 1308418
Leiguarda R, Roncoroni A, Taratuto AL, Jost L, Berthier M, Nogues M, Freilij H
Neurology 1990 May;40(5):850-1. PMID: 2109844

Therapy

Colantonio LD, Prado N, Segura EL, Sosa-Estani S
PLoS Negl Trop Dis 2016 May;10(5):e0004651. Epub 2016 May 9 doi: 10.1371/journal.pntd.0004651. PMID: 27158908Free PMC Article
Zulantay I, Corral G, Guzman MC, Aldunate F, Guerra W, Cruz I, Araya A, Tapia V, Marquez F, Muñoz C, Apt W
Ann Trop Med Parasitol 2011 Mar;105(2):123-8. doi: 10.1179/136485911X12899838413583. PMID: 21396248Free PMC Article
Tonelli RR, Torrecilhas AC, Jacysyn JF, Juliano MA, Colli W, Alves MJ
Parasitology 2011 Apr;138(4):481-92. Epub 2010 Nov 2 doi: 10.1017/S0031182010001411. PMID: 21040619
Kinoshita-Yanaga AT, Toledo MJ, Araújo SM, Vier BP, Gomes ML
Rev Inst Med Trop Sao Paulo 2009 Sep-Oct;51(5):295-8. PMID: 19893984
Amato Neto V
Rev Inst Med Trop Sao Paulo 1999 Jul-Aug;41(4):211-3. PMID: 10564912

Prognosis

Pinto A, Pett S, Jackson Y
Aust Fam Physician 2014 Jul;43(7):440-2. PMID: 25006603
Pérez-Molina JA
Curr Opin Infect Dis 2014 Feb;27(1):9-15. doi: 10.1097/QCO.0000000000000023. PMID: 24275694
de Meis J, Morrot A, Farias-de-Oliveira DA, Villa-Verde DM, Savino W
PLoS Negl Trop Dis 2009 Jul 7;3(7):e417. doi: 10.1371/journal.pntd.0000417. PMID: 19582140Free PMC Article
Campbell DA, Westenberger SJ, Sturm NR
Curr Mol Med 2004 Sep;4(6):549-62. PMID: 15357207
Levi GC, Lobo IM, Kallás EG, Amato Neto V
Rev Inst Med Trop Sao Paulo 1996 Jan-Feb;38(1):35-8. PMID: 8762637

Clinical prediction guides

Díaz-Luján C, Triquell MF, Castillo C, Hardisson D, Kemmerling U, Fretes RE
Acta Trop 2016 Dec;164:360-368. Epub 2016 Sep 26 doi: 10.1016/j.actatropica.2016.09.021. PMID: 27686961
Apt W, Zulantay I, Arnello M, Oddó D, González S, Rodríguez J, Kemmerling U, Truyens C, Carlier Y
Trans R Soc Trop Med Hyg 2013 Feb;107(2):98-104. Epub 2012 Nov 8 doi: 10.1093/trstmh/trs013. PMID: 23222947
Castro-Sesquen YE, Gilman RH, Yauri V, Angulo N, Verastegui M, Velásquez DE, Sterling CR, Martin D, Bern C
Am J Pathol 2011 Jul;179(1):281-8. Epub 2011 May 14 doi: 10.1016/j.ajpath.2011.03.043. PMID: 21703410Free PMC Article
Tonelli RR, Torrecilhas AC, Jacysyn JF, Juliano MA, Colli W, Alves MJ
Parasitology 2011 Apr;138(4):481-92. Epub 2010 Nov 2 doi: 10.1017/S0031182010001411. PMID: 21040619
Levi GC, Lobo IM, Kallás EG, Amato Neto V
Rev Inst Med Trop Sao Paulo 1996 Jan-Feb;38(1):35-8. PMID: 8762637

Recent systematic reviews

Pérez-Molina JA, Rodríguez-Guardado A, Soriano A, Pinazo MJ, Carrilero B, García-Rodríguez M, Salas J, Torrús D, Soler-Ferrer C, Puente S, Haro-González JL, Martín-Rabadán P, Gascon J; Chagas Study Group Of The SEMTSI (Sociedad Española de Medicina Tropical Y Salud Internacional [Spanish Society Of Tropical Medicine And International Health]).
HIV Clin Trials 2011 Nov-Dec;12(6):287-98. doi: 10.1310/hct1206-287. PMID: 22189148

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