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Items: 6

1.

Osteoarthritis susceptibility 1

Osteoarthritis (OA) is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis (Meulenbelt et al., 2006). Clinical problems include pain and joint stiffness often leading to significant disability and joint replacement. Osteoarthritis exhibits a clear predilection for specific joints; it appears most commonly in the hip and knee joints and lumbar and cervical spine, as well as in the distal interphalangeal and the first carpometacarpal (base of thumb) and proximal interphalangeal joints of the hand; however, patients with osteoarthritis may have 1, a few, or all of these sites affected (Stefansson et al., 2003). According to a conservative estimate, greater than 70% of the population of the United States at age 65 years is affected by the disease, reflecting its age dependence. Genetic Heterogeneity of Susceptibility to Osteoarthritis Susceptibility to osteoarthritis has been associated with variation in other genes: OS2 (140600) with variation in the MATN3 gene (602109) on chromosome 2p24; OS3 (607850) with variation in the ASPN gene (608135) on chromosome 9q22; and OS5 (612400) with variation in the GDF5 gene (601146) on chromosome 20q11. Other susceptibility loci for osteoarthritis have been mapped to chromosomes 2q33 (OS4; 610839) and 3p24 (OS6; 612401). [from GTR]

MedGen UID:
45244
Concept ID:
C0029408
Disease or Syndrome
2.

Glucosamine

amino sugar derivative of glucose, substituted at the 2 position, occurring in glycosaminoglycans and a variety of complex polysaccharides such as blood group substances. [from CRISP]

MedGen UID:
6622
Concept ID:
C0017718
Organic Chemical; Pharmacologic Substance
3.

Chondroitin

A mucopolysaccharide constituent of chondrin. (Grant & Hackh's Chemical Dictionary, 5th ed) [from MeSH]

MedGen UID:
3416
Concept ID:
C0008454
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
4.

Osteoarthritis

MedGen UID:
505348
Concept ID:
CN002503
Finding
5.

Chondroitin sulfate

Derivatives of chondroitin which have a sulfate moiety esterified to the galactosamine moiety of chondroitin. Chondroitin sulfate A, or chondroitin 4-sulfate, and chondroitin sulfate C, or chondroitin 6-sulfate, have the sulfate esterified in the 4- and 6-positions, respectively. Chondroitin sulfate B (beta heparin; DERMATAN SULFATE) is a misnomer and this compound is not a true chondroitin sulfate. [from MeSH]

MedGen UID:
40273
Concept ID:
C0008466
Biologically Active Substance; Organic Chemical; Pharmacologic Substance
6.

Glucosamine Sulfate

An amino sugar (2-amino, 2-deoxyglucose) in cell membranes, Glucosamine Sulfate is believed to play a role in cartilage formation and repair. Long-term glucosamine sulfate treatment retards progression of knee osteoarthritis; the mechanism appears to involve glucosamine's role as an essential substrate for glycosaminoglycans and hyaluronic acid, needed for formation of the joint proteoglycan structural matrix. (NCI04) [from NCI]

MedGen UID:
6623
Concept ID:
C0017720
Organic Chemical; Pharmacologic Substance
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