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Carcinoma of cervix

MedGen UID:
86222
Concept ID:
C0302592
Neoplastic Process
Synonyms: Cervical cancer; Cervical cancer, somatic
SNOMED CT: Cancer of cervix (363354003); Ca cervix (363354003); Carcinoma of cervix (285432005)
 
Gene (location): FGFR3 (4p16.3)
OMIM®: 603956

Definition

The cervix is the lower part of the uterus, the place where a baby grows during pregnancy. Cervical cancer is caused by several types of a virus called human papillomaviruses (HPV). The virus spreads through sexual contact. Most women's bodies are able to fight HPV infection. But sometimes the virus leads to cancer. You're at higher risk if you smoke, have many children, use birth control pills for a long time, or have HIV infection. . Cervical cancer may not cause any symptoms at first, but later, you may have pelvic pain or bleeding from the vagina. It usually takes several years for normal cells in the cervix to turn into cancer cells. Your health care provider can find abnormal cells by doing a Pap test - examining cells from the cervix under a microscope. By getting regular Pap tests and pelvic exams you can find and treat changing cells before they turn into cancer. A vaccine for girls and young women protects against the four types of HPV that cause most cervical cancers. . NIH: National Cancer Institute.  [from MedlinePlus]

Clinical features

Neoplasm
MedGen UID:
10294
Concept ID:
C0027651
Neoplastic Process
A general term for autonomous tissue growth in which the malignancy status has not been established and for which the transformed cell type has not been specifically identified.

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCarcinoma of cervix

Recent clinical studies

Etiology

Aggarwal R, Misra S, Guleria C, Suri V, Mangat N, Sharma M, Nijhawan R, Minz R
Gynecol Oncol 2015 Aug;138(2):358-62. Epub 2015 May 27 doi: 10.1016/j.ygyno.2015.05.029. PMID: 26024767
Hasan S, Hameed A, Saleem S, Shahid SM, Haider G, Azhar A
Tumour Biol 2015 Jul;36(7):5195-9. Epub 2015 Feb 9 doi: 10.1007/s13277-015-3175-y. PMID: 25663492
Sinaa M, Oukabli M, Albouzidi A
Pan Afr Med J 2014;19:99. Epub 2014 Sep 29 doi: 10.11604/pamj.2014.19.99.5241. PMID: 25722772Free PMC Article
Haider G, Parveen Z, Anjum F, Munir A
J Ayub Med Coll Abbottabad 2013 Jan-Jun;25(1-2):26-7. PMID: 25098046
Kulkarni SS, Kulkarni SS, Vastrad PP, Kulkarni BB, Markande AR, Kadakol GS, Hiremath SV, Kaliwal S, Patil BR, Gai PB
Asian Pac J Cancer Prev 2011;12(3):645-8. PMID: 21627358

Diagnosis

Rathore R, Arora VK, Singh B
Diagn Cytopathol 2017 Mar;45(3):239-242. Epub 2016 Nov 7 doi: 10.1002/dc.23629. PMID: 28211234
Benhayoune K, El Fatemi H, Bannani A, Melhouf A, Harmouch T
Pan Afr Med J 2015;20:77. Epub 2015 Jan 29 doi: 10.11604/pamj.2015.20.77.5720. PMID: 26090035Free PMC Article
Sinaa M, Oukabli M, Albouzidi A
Pan Afr Med J 2014;19:99. Epub 2014 Sep 29 doi: 10.11604/pamj.2014.19.99.5241. PMID: 25722772Free PMC Article
Chen JL, Huang CY, Huang YS, Chen RJ, Wang CW, Chen YH, Cheng JC, Cheng AL, Kuo SH
Acta Obstet Gynecol Scand 2014 Jul;93(7):661-8. Epub 2014 Apr 22 doi: 10.1111/aogs.12383. PMID: 24666257
Haider G, Parveen Z, Anjum F, Munir A
J Ayub Med Coll Abbottabad 2013 Jan-Jun;25(1-2):26-7. PMID: 25098046

Therapy

Hashmi H, Maqbool A, Ahmed S, Ahmed A, Sheikh K, Ahmed A
J Coll Physicians Surg Pak 2016 Apr;26(4):302-5. doi: 2296. PMID: 27097702
Varghese SS, Ram TS, Pavamani SP, Thomas EM, Jeyaseelan V, Viswanathan PN
J Cancer Res Ther 2014 Apr-Jun;10(2):330-6. doi: 10.4103/0973-1482.136621. PMID: 25022387
Chen JL, Huang CY, Huang YS, Chen RJ, Wang CW, Chen YH, Cheng JC, Cheng AL, Kuo SH
Acta Obstet Gynecol Scand 2014 Jul;93(7):661-8. Epub 2014 Apr 22 doi: 10.1111/aogs.12383. PMID: 24666257
Ram H, Kumar M, Bhatt ML, Shadab M
BMJ Case Rep 2013 Jun 14;2013 doi: 10.1136/bcr-2013-010020. PMID: 23771978Free PMC Article
Kulkarni SS, Kulkarni SS, Vastrad PP, Kulkarni BB, Markande AR, Kadakol GS, Hiremath SV, Kaliwal S, Patil BR, Gai PB
Asian Pac J Cancer Prev 2011;12(3):645-8. PMID: 21627358

Prognosis

Rathore R, Arora VK, Singh B
Diagn Cytopathol 2017 Mar;45(3):239-242. Epub 2016 Nov 7 doi: 10.1002/dc.23629. PMID: 28211234
Hashmi H, Maqbool A, Ahmed S, Ahmed A, Sheikh K, Ahmed A
J Coll Physicians Surg Pak 2016 Apr;26(4):302-5. doi: 2296. PMID: 27097702
Chen JL, Huang CY, Huang YS, Chen RJ, Wang CW, Chen YH, Cheng JC, Cheng AL, Kuo SH
Acta Obstet Gynecol Scand 2014 Jul;93(7):661-8. Epub 2014 Apr 22 doi: 10.1111/aogs.12383. PMID: 24666257
Hoskin PJ, Rojas AM, Peiris SN, Mullassery V, Chong IY
Clin Oncol (R Coll Radiol) 2014 Apr;26(4):179-84. Epub 2014 Jan 15 doi: 10.1016/j.clon.2013.11.023. PMID: 24439272
Kulkarni SS, Kulkarni SS, Vastrad PP, Kulkarni BB, Markande AR, Kadakol GS, Hiremath SV, Kaliwal S, Patil BR, Gai PB
Asian Pac J Cancer Prev 2011;12(3):645-8. PMID: 21627358

Clinical prediction guides

Aggarwal R, Misra S, Guleria C, Suri V, Mangat N, Sharma M, Nijhawan R, Minz R
Gynecol Oncol 2015 Aug;138(2):358-62. Epub 2015 May 27 doi: 10.1016/j.ygyno.2015.05.029. PMID: 26024767
Hasan S, Hameed A, Saleem S, Shahid SM, Haider G, Azhar A
Tumour Biol 2015 Jul;36(7):5195-9. Epub 2015 Feb 9 doi: 10.1007/s13277-015-3175-y. PMID: 25663492
Chen JL, Huang CY, Huang YS, Chen RJ, Wang CW, Chen YH, Cheng JC, Cheng AL, Kuo SH
Acta Obstet Gynecol Scand 2014 Jul;93(7):661-8. Epub 2014 Apr 22 doi: 10.1111/aogs.12383. PMID: 24666257
Hoskin PJ, Rojas AM, Peiris SN, Mullassery V, Chong IY
Clin Oncol (R Coll Radiol) 2014 Apr;26(4):179-84. Epub 2014 Jan 15 doi: 10.1016/j.clon.2013.11.023. PMID: 24439272
Kulkarni SS, Kulkarni SS, Vastrad PP, Kulkarni BB, Markande AR, Kadakol GS, Hiremath SV, Kaliwal S, Patil BR, Gai PB
Asian Pac J Cancer Prev 2011;12(3):645-8. PMID: 21627358

Recent systematic reviews

Chen JL, Huang CY, Huang YS, Chen RJ, Wang CW, Chen YH, Cheng JC, Cheng AL, Kuo SH
Acta Obstet Gynecol Scand 2014 Jul;93(7):661-8. Epub 2014 Apr 22 doi: 10.1111/aogs.12383. PMID: 24666257
Nandwani PK, Vyas RK, Neema JP, Suryanarayan UK, Bhavsar DC, Jani KR
J Cancer Res Ther 2007 Apr-Jun;3(2):111-5. PMID: 17998736

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