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Inflammation

MedGen UID:
7072
Concept ID:
C0021368
Pathologic Function
Synonyms: Inflammations
SNOMED CT: Inflammation (257552002); Inflammation (23583003); Inflammatory reaction (23583003)
 

Definition

A localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVInflammation

Recent clinical studies

Etiology

Hove-Skovsgaard M, Gaardbo JC, Kolte L, Winding K, Seljeflot I, Svardal A, Berge RK, Gerstoft J, Ullum H, Trøseid M, Nielsen SD
BMC Infect Dis 2017 Mar 29;17(1):234. doi: 10.1186/s12879-017-2334-8. PMID: 28356058Free PMC Article
Wang C, Ha X, Li W, Xu P, Gu Y, Wang T, Wang Y, Xie J, Zhang J
Inflammation 2017 Feb;40(1):42-51. doi: 10.1007/s10753-016-0450-z. PMID: 27714571
Karakus E, Halici Z, Albayrak A, Bayir Y, Demirci E, Aydin A, Ozturk-Karagoz B, Cadirci E, Ayan AK, Sahin A, Unal D
Inflammation 2016 Feb;39(1):336-346. doi: 10.1007/s10753-015-0254-6. PMID: 26412256
Mo XM, Sun HX
Inflammation 2015;38(3):1374-83. doi: 10.1007/s10753-015-0109-1. PMID: 25676435
Qian X, Yin T, Li T, Kang C, Guo R, Sun B, Liu C
Inflammation 2012 Aug;35(4):1507-11. doi: 10.1007/s10753-012-9464-3. PMID: 22527145

Diagnosis

Spiga R, Marini MA, Mancuso E, Di Fatta C, Fuoco A, Perticone F, Andreozzi F, Mannino GC, Sesti G
Arterioscler Thromb Vasc Biol 2017 Jun;37(6):1241-1249. Epub 2017 Apr 13 doi: 10.1161/ATVBAHA.117.309128. PMID: 28408375
Hagman DK, Larson I, Kuzma JN, Cromer G, Makar K, Rubinow KB, Foster-Schubert KE, van Yserloo B, Billing PS, Landerholm RW, Crouthamel M, Flum DR, Cummings DE, Kratz M
Metabolism 2017 May;70:12-22. Epub 2017 Feb 2 doi: 10.1016/j.metabol.2017.01.030. PMID: 28403936Free PMC Article
Hove-Skovsgaard M, Gaardbo JC, Kolte L, Winding K, Seljeflot I, Svardal A, Berge RK, Gerstoft J, Ullum H, Trøseid M, Nielsen SD
BMC Infect Dis 2017 Mar 29;17(1):234. doi: 10.1186/s12879-017-2334-8. PMID: 28356058Free PMC Article
Adabimohazab R, Garfinkel A, Milam EC, Frosch O, Mangone A, Convit A
Inflammation 2016 Jun;39(3):994-1003. doi: 10.1007/s10753-016-0329-z. PMID: 26956471Free PMC Article
Qian X, Yin T, Li T, Kang C, Guo R, Sun B, Liu C
Inflammation 2012 Aug;35(4):1507-11. doi: 10.1007/s10753-012-9464-3. PMID: 22527145

Therapy

Phosri S, Jangpromma N, Patramanon R, Kongyingyoes B, Mahakunakorn P, Klaynongsruang S
Inflammation 2017 Feb;40(1):205-220. doi: 10.1007/s10753-016-0471-7. PMID: 27838796
Kariminik A, Dabiri S, Yaghobi R
Inflammation 2016 Aug;39(4):1514-9. doi: 10.1007/s10753-016-0385-4. PMID: 27277862
Adabimohazab R, Garfinkel A, Milam EC, Frosch O, Mangone A, Convit A
Inflammation 2016 Jun;39(3):994-1003. doi: 10.1007/s10753-016-0329-z. PMID: 26956471Free PMC Article
Ku SK, Kwak S, Bae JS
Inflammation 2014 Dec;37(6):2164-73. doi: 10.1007/s10753-014-9950-x. PMID: 24950780
Holfeld J, Tepeköylü C, Kozaryn R, Urbschat A, Zacharowski K, Grimm M, Paulus P
Inflammation 2014 Feb;37(1):65-70. doi: 10.1007/s10753-013-9712-1. PMID: 23948864

Prognosis

Harris WB, Zhang C, Liu Y, Robertson DK, Akbashev MY, Lingerfelt BM, Kucuk O, Carthon BC, Gillespie TW, Osunkoya AO, Master VA
Tumour Biol 2017 Jun;39(6):1010428317705514. doi: 10.1177/1010428317705514. PMID: 28618965
Seifert SM, Castillo-Mancilla JR, Erlandson KM, Anderson PL
Expert Opin Drug Metab Toxicol 2017 Jun;13(6):641-650. Epub 2017 Apr 3 doi: 10.1080/17425255.2017.1311323. PMID: 28335648
Orsó E, Schmitz G
Clin Res Cardiol Suppl 2017 Mar;12(Suppl 1):31-37. doi: 10.1007/s11789-017-0084-1. PMID: 28188431Free PMC Article
Bernelot Moens SJ, Verweij SL, van der Valk FM, van Capelleveen JC, Kroon J, Versloot M, Verberne HJ, Marquering HA, Duivenvoorden R, Vogt L, Stroes ES
J Am Soc Nephrol 2017 Apr;28(4):1278-1285. Epub 2016 Oct 31 doi: 10.1681/ASN.2016030317. PMID: 27799487Free PMC Article
Adabimohazab R, Garfinkel A, Milam EC, Frosch O, Mangone A, Convit A
Inflammation 2016 Jun;39(3):994-1003. doi: 10.1007/s10753-016-0329-z. PMID: 26956471Free PMC Article

Clinical prediction guides

Seifert SM, Castillo-Mancilla JR, Erlandson KM, Anderson PL
Expert Opin Drug Metab Toxicol 2017 Jun;13(6):641-650. Epub 2017 Apr 3 doi: 10.1080/17425255.2017.1311323. PMID: 28335648
Galvão I, Vago JP, Barroso LC, Tavares LP, Queiroz-Junior CM, Costa VV, Carneiro FS, Ferreira TP, Silva PM, Amaral FA, Sousa LP, Teixeira MM
Eur J Immunol 2017 Mar;47(3):585-596. Epub 2017 Jan 12 doi: 10.1002/eji.201646551. PMID: 27995621
Bernelot Moens SJ, Verweij SL, van der Valk FM, van Capelleveen JC, Kroon J, Versloot M, Verberne HJ, Marquering HA, Duivenvoorden R, Vogt L, Stroes ES
J Am Soc Nephrol 2017 Apr;28(4):1278-1285. Epub 2016 Oct 31 doi: 10.1681/ASN.2016030317. PMID: 27799487Free PMC Article
Adabimohazab R, Garfinkel A, Milam EC, Frosch O, Mangone A, Convit A
Inflammation 2016 Jun;39(3):994-1003. doi: 10.1007/s10753-016-0329-z. PMID: 26956471Free PMC Article
Rakesh KS, Jagadish S, Balaji KS, Zameer F, Swaroop TR, Mohan CD, Jayarama S, Rangappa KS
Inflammation 2016 Feb;39(1):269-280. doi: 10.1007/s10753-015-0247-5. PMID: 26363638

Recent systematic reviews

Ligthart S, Marzi C, Aslibekyan S, Mendelson MM, Conneely KN, Tanaka T, Colicino E, Waite LL, Joehanes R, Guan W, Brody JA, Elks C, Marioni R, Jhun MA, Agha G, Bressler J, Ward-Caviness CK, Chen BH, Huan T, Bakulski K, Salfati EL; WHI-EMPC Investigators., Fiorito G; CHARGE epigenetics of Coronary Heart Disease., Wahl S, Schramm K, Sha J, Hernandez DG, Just AC, Smith JA, Sotoodehnia N, Pilling LC, Pankow JS, Tsao PS, Liu C, Zhao W, Guarrera S, Michopoulos VJ, Smith AK, Peters MJ, Melzer D, Vokonas P, Fornage M, Prokisch H, Bis JC, Chu AY, Herder C, Grallert H, Yao C, Shah S, McRae AF, Lin H, Horvath S, Fallin D, Hofman A, Wareham NJ, Wiggins KL, Feinberg AP, Starr JM, Visscher PM, Murabito JM, Kardia SL, Absher DM, Binder EB, Singleton AB, Bandinelli S, Peters A, Waldenberger M, Matullo G, Schwartz JD, Demerath EW, Uitterlinden AG, van Meurs JB, Franco OH, Chen YI, Levy D, Turner ST, Deary IJ, Ressler KJ, Dupuis J, Ferrucci L, Ong KK, Assimes TL, Boerwinkle E, Koenig W, Arnett DK, Baccarelli AA, Benjamin EJ, Dehghan A
Genome Biol 2016 Dec 12;17(1):255. doi: 10.1186/s13059-016-1119-5. PMID: 27955697Free PMC Article
Schwingshackl L, Christoph M, Hoffmann G
Nutrients 2015 Sep 11;7(9):7651-75. doi: 10.3390/nu7095356. PMID: 26378571Free PMC Article
Hung RJ, Ulrich CM, Goode EL, Brhane Y, Muir K, Chan AT, Marchand LL, Schildkraut J, Witte JS, Eeles R, Boffetta P, Spitz MR, Poirier JG, Rider DN, Fridley BL, Chen Z, Haiman C, Schumacher F, Easton DF, Landi MT, Brennan P, Houlston R, Christiani DC, Field JK, Bickeböller H, Risch A, Kote-Jarai Z, Wiklund F, Grönberg H, Chanock S, Berndt SI, Kraft P, Lindström S, Al Olama AA, Song H, Phelan C, Wentzensen N, Peters U, Slattery ML; GECCO., Sellers TA; FOCI., Casey G, Gruber SB; CORECT., Hunter DJ; DRIVE., Amos CI, Henderson B; GAME-ON Network.
J Natl Cancer Inst 2015 Nov;107(11) Epub 2015 Aug 29 doi: 10.1093/jnci/djv246. PMID: 26319099Free PMC Article
Fritsche KL
Adv Nutr 2015 May;6(3):293S-301S. Epub 2015 May 15 doi: 10.3945/an.114.006940. PMID: 25979502Free PMC Article
Papathanassoglou ED, Miltiadous P, Karanikola MN
Biol Res Nurs 2015 Oct;17(5):521-39. Epub 2014 Oct 29 doi: 10.1177/1099800414555411. PMID: 25358684

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