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1.

NSC 663249

MedGen UID:
483438
Concept ID:
C3489485
Organic Chemical; Pharmacologic Substance
2.

Triapine

A synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis. This agent has been shown to inhibit tumor growth in vitro. (NCI04) [from NCI]

MedGen UID:
389154
Concept ID:
C2004325
Organic Chemical; Pharmacologic Substance
3.

Malignant Lung Neoplasm

A primary or metastatic malignant neoplasm involving the lung. [from NCI]

MedGen UID:
66885
Concept ID:
C0242379
Neoplastic Process
4.

Gemcitabine

MedGen UID:
12514
Concept ID:
C0045093
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
5.

SCLEROSING CHOLANGITIS, NEONATAL

MedGen UID:
1393230
Concept ID:
C4479344
Disease or Syndrome
6.

Sclerosing cholangitis, neonatal

Neonatal sclerosing cholangitis is a rare autosomal recessive form of severe liver disease with onset in infancy. Affected infants have jaundice, cholestasis, acholic stools, and progressive liver dysfunction resulting in fibrosis and cirrhosis; most require liver transplantation in the first few decades of life. Cholangiography shows patent biliary ducts, but there are bile duct irregularities (summary by Girard et al., 2016; Grammatikopoulos et al., 2016). [from OMIM]

MedGen UID:
910848
Concept ID:
CN241830
Disease or Syndrome
7.

lung cancer

MedGen UID:
880193
Concept ID:
CN235597
Finding
8.

Non-small cell lung carcinoma

MedGen UID:
850989
Concept ID:
CN231772
Finding
9.

Small cell lung carcinoma

MedGen UID:
850987
Concept ID:
CN231771
Finding
10.

Furriers lung

MedGen UID:
538594
Concept ID:
C0264476
Disease or Syndrome
11.

Coffee-workers lung

MedGen UID:
538589
Concept ID:
C0264468
Disease or Syndrome
12.

Malt-workers lung

MedGen UID:
510125
Concept ID:
C0155888
Disease or Syndrome
13.

Cheese-washers lung

MedGen UID:
507549
Concept ID:
C0007969
Disease or Syndrome
14.

Lung cancer

Lung cancer is the leading cause of cancer deaths in the U.S. and worldwide. The 2 major forms of lung cancer are nonsmall cell lung cancer and small cell lung cancer (see 182280), which account for 85% and 15% of all lung cancers, respectively. Nonsmall cell lung cancer can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. Cigarette smoking causes all types of lung cancer, but it is most strongly linked with small cell lung cancer and squamous cell carcinoma. Adenocarcinoma is the most common type in patients who have never smoked. Nonsmall cell lung cancer is often diagnosed at an advanced stage and has a poor prognosis (summary by Herbst et al., 2008). [from OMIM]

MedGen UID:
195765
Concept ID:
C0684249
Neoplastic Process
15.

Small cell lung cancer

MedGen UID:
57450
Concept ID:
C0149925
Neoplastic Process
16.

Non-small cell lung cancer

Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor. Lung cancer may not cause signs or symptoms in its early stages. Some people with lung cancer have chest pain, frequent coughing, blood in the mucus, breathing problems, trouble swallowing or speaking, loss of appetite and weight loss, fatigue, or swelling in the face or neck. Additional symptoms can develop if the cancer spreads (metastasizes) into other tissues. Lung cancer occurs most often in adults in their sixties or seventies. Most people who develop lung cancer have a history of long-term tobacco smoking; however, the condition can occur in people who have never smoked.Lung cancer is generally divided into two types, small cell lung cancer and non-small cell lung cancer, based on the size of the affected cells when viewed under a microscope. Non-small cell lung cancer accounts for 85 percent of lung cancer, while small cell lung cancer accounts for the remaining 15 percent.Small cell lung cancer grows quickly and in more than half of cases the cancer has spread beyond the lung by the time the condition is diagnosed. Small cell lung cancer often metastasizes, most commonly to the liver, brain, bones, and adrenal glands (small hormone-producing glands located on top of each kidney). After diagnosis, most people with small cell lung cancer survive for about 1 year; less than seven percent survive 5 years.Non-small cell lung cancer is divided into three main subtypes: adenocarcinoma, squamous cell carcinoma, and large cell lung carcinoma. Adenocarcinoma arises from the cells that line the small air sacs (alveoli) located throughout the lungs. Squamous cell carcinoma arises from squamous cells that line the passages leading from the windpipe (trachea) to the lungs (bronchi). Large cell carcinoma arises from epithelial cells that line the lungs. Large cell carcinoma encompasses non-small cell lung cancers that do not appear to be adenocarcinomas or squamous cell carcinomas. The 5-year survival rate for people with non-small cell lung cancer is usually between 11 and 17 percent; it can be lower or higher depending on the subtype and stage of the cancer.
[from GHR]

MedGen UID:
40104
Concept ID:
C0007131
Neoplastic Process
17.

Neoplasm of lung

MedGen UID:
7400
Concept ID:
C0024121
Neoplastic Process
18.

Methemoglobinemia

MedGen UID:
6339
Concept ID:
C0025637
Disease or Syndrome; Finding
19.

Stable Disease

Cancer that is neither decreasing nor increasing in extent or severity. [from NCI]

MedGen UID:
151811
Concept ID:
C0677946
Finding
20.

Acute

Sudden appearance of disease manifestations over a short period of time. [from HPO]

MedGen UID:
61381
Concept ID:
C0205178
Temporal Concept
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