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Self-mutilation

MedGen UID:
88371
Concept ID:
C0085271
Finding; Individual Behavior
Synonyms: Deliberate self-harm
SNOMED CT: Deliberate self-harm (248062006); Self-abusive behavior (248062006); Self-destructive behavior (248062006); SIB - Self-injurious behavior (248062006); Self-injurious behavior (248062006)
 
HPO: HP:0100716

Definition

Aggression towards oneself. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSelf-mutilation

Conditions with this feature

Hyperlysinuria with hyperammonemia
MedGen UID:
120650
Concept ID:
C0268555
Disease or Syndrome
Succinate-semialdehyde dehydrogenase deficiency
MedGen UID:
124340
Concept ID:
C0268631
Disease or Syndrome
Succinic semialdehyde dehydrogenase (SSADH) deficiency is characterized by infantile-onset hypotonia, developmental delay, cognitive impairment, expressive language deficit, and mild ataxia. Epilepsy is present in about half of affected individuals and is more common in adults. Hyperkinetic behavior, aggression, self-injurious behaviors, hallucinations, and sleep disturbances have been reported in nearly half of all affected individuals, more commonly in those who are older. Basal ganglia signs including choreoathetosis, dystonia, and myoclonus have been reported in a few individuals with earlier-onset, more severe disease. Involvement beyond the central nervous system has not been described. Individuals with SSADH deficiency typically have 4-hydroxybutyric aciduria present on urine organic acid analysis. Head MRI reveals T2 hyperintensities in multiple regions, involving the globus pallidi, cerebellar dentate nuclei, subthalamic nuclei, subcortical white matter, and brain stem, as well as cerebral and sometimes cerebellar atrophy. EEG findings include background slowing and spike discharges that are usually generalized.
De Lange syndrome
MedGen UID:
78752
Concept ID:
C0270972
Congenital Abnormality
Classic Cornelia de Lange syndrome (CdLS) is characterized by distinctive facial features, growth retardation (prenatal onset; <5th centile throughout life), hirsutism, and upper limb reduction defects that range from subtle phalangeal abnormalities to oligodactyly (missing digits). Craniofacial features include synophrys, highly arched eyebrows, long eyelashes, short nose with anteverted nares, small widely spaced teeth, and microcephaly. IQ ranges from below 30 to 102 (mean: 53). Many individuals demonstrate autistic and self-destructive tendencies. Frequent findings include cardiac septal defects, gastrointestinal dysfunction, hearing loss, myopia, and cryptorchidism or hypoplastic genitalia. Individuals with a milder phenotype have less severe growth, cognitive, and limb involvement, but often have facial features consistent with CdLS.
Gomez Lopez Hernandez syndrome
MedGen UID:
163201
Concept ID:
C0795959
Disease or Syndrome
Gomez-Lopez-Hernandez syndrome, also known as cerebellotrigeminal dermal dysplasia, is a rare neurocutaneous syndrome classically characterized by the triad of rhombencephalosynapsis, trigeminal anesthesia, often giving rise to corneal opacities, and bilateral parietal or parietooccipital alopecia, However, trigeminal anesthesia is an inconsistent finding (summary by Sukhudyan et al., 2010).
Primrose syndrome
MedGen UID:
162911
Concept ID:
C0796121
Disease or Syndrome
Primrose syndrome consists of recognizable facial features, macrocephaly, mental retardation, enlarged and calcified external ears, sparse body hair, and distal muscle wasting (summary by Carvalho and Speck-Martins, 2011). Patients with a deletion syndrome involving 3q13.31 (615433) exhibit features overlapping those of Primrose syndrome.
Pettigrew syndrome
MedGen UID:
162924
Concept ID:
C0796254
Disease or Syndrome
Pettigrew syndrome is characterized by mental retardation and highly variable additional features, including choreoathetosis, hydrocephalus, Dandy-Walker malformation, seizures, and iron or calcium deposition in the brain, both between and within families (summary by Cacciagli et al., 2014). See 311510 for another X-linked mental retardation syndrome associated with basal ganglia disease (Waisman syndrome). See 220219 for another mental retardation syndrome with Dandy-Walker malformation.
Brachydactyly-Mental Retardation syndrome
MedGen UID:
373895
Concept ID:
C1838126
Disease or Syndrome
2q37 microdeletion syndrome is characterized by mild-moderate developmental delay/intellectual disability, brachymetaphalangy of digits 3-5 (often digit 4 alone) (>50%), short stature, obesity, hypotonia, characteristic facial appearance, autism or autism spectrum disorder (30%), joint hypermobility/dislocation, and scoliosis. Other findings include seizures (20%-35%), congenital heart disease, CNS abnormalities (hydrocephalus, dilated ventricles), umbilical/inguinal hernia, tracheomalacia, situs abnormalities, gastrointestinal abnormalities, and renal malformations. Wilms tumor has been reported in two individuals.
Mental retardation, autosomal dominant 1
MedGen UID:
409857
Concept ID:
C1969562
Disease or Syndrome
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 31
MedGen UID:
894942
Concept ID:
C4225357
Disease or Syndrome

Recent clinical studies

Etiology

Meijer KA, Russo RR, Adhvaryu DV
Orthopedics 2014 Apr;37(4):e391-4. doi: 10.3928/01477447-20140401-62. PMID: 24762846
Ciorba I, Farcus O, Giger R, Nisa L
Postgrad Med J 2014 Apr;90(1062):191-200. Epub 2014 Feb 10 doi: 10.1136/postgradmedj-2013-132036. PMID: 24516174
Mishra KK, Reddy S, Khairkar P
Int J STD AIDS 2014 Mar;25(4):312-4. Epub 2013 Sep 10 doi: 10.1177/0956462413501647. PMID: 24021211
Zanarini MC, Laudate CS, Frankenburg FR, Wedig MM, Fitzmaurice G
J Pers Disord 2013 Dec;27(6):783-94. Epub 2013 Jun 24 doi: 10.1521/pedi_2013_27_115. PMID: 23795756Free PMC Article
Gahr M, Plener PL, Kölle MA, Freudenmann RW, Schönfeldt-Lecuona C
Psychiatry Res 2012 Dec 30;200(2-3):977-83. Epub 2012 Jul 28 doi: 10.1016/j.psychres.2012.06.028. PMID: 22841344

Diagnosis

Chick J
Alcohol Alcohol 2015 Jul;50(4):377-8. Epub 2015 May 5 doi: 10.1093/alcalc/agv041. PMID: 25947629
Askari M, Grewal H, Alexander SA
J Mass Dent Soc 2015 Winter;63(4):24-6. PMID: 25872284
Kharbach Y, Amiroune D, Ahsaini M, Bout A, Riyach O, Stuurman-Wieringa RE, Mellas S, Tazi MF, Khallouk A, El Fassi MJ, Rammouz I, Farih MH
J Med Case Rep 2014 Jul 7;8:246. doi: 10.1186/1752-1947-8-246. PMID: 25000934Free PMC Article
Fantuzzo JJ, Rogér JM, Barroner MD, Karp JM
J Oral Maxillofac Surg 2014 Jul;72(7):1327.e1-4. Epub 2014 Feb 16 doi: 10.1016/j.joms.2014.02.016. PMID: 24679955
Schwerkoske JP, Caplan JP, Benford DM
Psychosomatics 2012 Jul-Aug;53(4):327-33. Epub 2012 May 30 doi: 10.1016/j.psym.2012.01.007. PMID: 22652302

Therapy

Anand JS, Habrat B, Barwina M, Waldman W
J Forensic Leg Med 2015 Feb;30:1-3. Epub 2014 Dec 13 doi: 10.1016/j.jflm.2014.12.003. PMID: 25623185
Meijer KA, Russo RR, Adhvaryu DV
Orthopedics 2014 Apr;37(4):e391-4. doi: 10.3928/01477447-20140401-62. PMID: 24762846
Fantuzzo JJ, Rogér JM, Barroner MD, Karp JM
J Oral Maxillofac Surg 2014 Jul;72(7):1327.e1-4. Epub 2014 Feb 16 doi: 10.1016/j.joms.2014.02.016. PMID: 24679955
Hong JM, Eun SC
J Craniofac Surg 2014;25(2):e116-8. doi: 10.1097/SCS.0000000000000447. PMID: 24621750
Gahr M, Plener PL, Kölle MA, Freudenmann RW, Schönfeldt-Lecuona C
Psychiatry Res 2012 Dec 30;200(2-3):977-83. Epub 2012 Jul 28 doi: 10.1016/j.psychres.2012.06.028. PMID: 22841344

Prognosis

Mowafy YN, Wahba NA, Sharaf AA
J Clin Pediatr Dent 2017;41(1):66-69. doi: 10.17796/1053-4628-41.1.66. PMID: 28052210
Tatu L, Bogousslavsky J
Front Neurol Neurosci 2016;38:143-54. Epub 2016 Apr 1 doi: 10.1159/000442653. PMID: 27035133
Kharbach Y, Amiroune D, Ahsaini M, Bout A, Riyach O, Stuurman-Wieringa RE, Mellas S, Tazi MF, Khallouk A, El Fassi MJ, Rammouz I, Farih MH
J Med Case Rep 2014 Jul 7;8:246. doi: 10.1186/1752-1947-8-246. PMID: 25000934Free PMC Article
Ciorba I, Farcus O, Giger R, Nisa L
Postgrad Med J 2014 Apr;90(1062):191-200. Epub 2014 Feb 10 doi: 10.1136/postgradmedj-2013-132036. PMID: 24516174
Zanarini MC, Laudate CS, Frankenburg FR, Wedig MM, Fitzmaurice G
J Pers Disord 2013 Dec;27(6):783-94. Epub 2013 Jun 24 doi: 10.1521/pedi_2013_27_115. PMID: 23795756Free PMC Article

Clinical prediction guides

Anand JS, Habrat B, Barwina M, Waldman W
J Forensic Leg Med 2015 Feb;30:1-3. Epub 2014 Dec 13 doi: 10.1016/j.jflm.2014.12.003. PMID: 25623185
Kharbach Y, Amiroune D, Ahsaini M, Bout A, Riyach O, Stuurman-Wieringa RE, Mellas S, Tazi MF, Khallouk A, El Fassi MJ, Rammouz I, Farih MH
J Med Case Rep 2014 Jul 7;8:246. doi: 10.1186/1752-1947-8-246. PMID: 25000934Free PMC Article
Dell'osso L, Mandelli L, Carlini M, Bouanani S, Rotondo A, Conversano C, Serretti A, Marazziti D
Neuropsychobiology 2013;68(4):250-7. Epub 2013 Nov 21 doi: 10.1159/000356228. PMID: 24280759
Schwerkoske JP, Caplan JP, Benford DM
Psychosomatics 2012 Jul-Aug;53(4):327-33. Epub 2012 May 30 doi: 10.1016/j.psym.2012.01.007. PMID: 22652302
Munerato MC, Moure SP, Machado V, Gomes FG
Clin Med Res 2011 Mar;9(1):42-5. Epub 2010 Sep 17 doi: 10.3121/cmr.2010.930. PMID: 20852088Free PMC Article

Recent systematic reviews

Gahr M, Plener PL, Kölle MA, Freudenmann RW, Schönfeldt-Lecuona C
Psychiatry Res 2012 Dec 30;200(2-3):977-83. Epub 2012 Jul 28 doi: 10.1016/j.psychres.2012.06.028. PMID: 22841344
Rissanen ML, Kylma J, Laukkanen E
Issues Ment Health Nurs 2011;32(9):575-83. doi: 10.3109/01612840.2011.578785. PMID: 21859408
Hicks KM, Hinck SM
J Am Acad Nurse Pract 2009 Aug;21(8):430-6. doi: 10.1111/j.1745-7599.2009.00426.x. PMID: 19689439
Large M, Babidge N, Andrews D, Storey P, Nielssen O
Schizophr Bull 2009 Sep;35(5):1012-21. Epub 2008 May 20 doi: 10.1093/schbul/sbn040. PMID: 18495646Free PMC Article
Parrott HJ, Murray BJ
Int J Clin Pract 2001 Jun;55(5):317-9. PMID: 11452679

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