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Secondary Metabolism

MedGen UID:
760259
Concept ID:
C0260000
Molecular Function
Synonyms: Metabolism, Secondary; Metabolisms, Secondary; Secondary Metabolisms
 

Definition

A physiochemical process which occurs in a wide range of organisms which unlike BASAL METABOLISM is not required for or essential to short-term survivability but to long-term general well-being of the organism. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecondary Metabolism

Recent clinical studies

Etiology

Gacek-Matthews A, Berger H, Sasaki T, Wittstein K, Gruber C, Lewis ZA, Strauss J
PLoS Genet 2016 Aug;12(8):e1006222. Epub 2016 Aug 22 doi: 10.1371/journal.pgen.1006222. PMID: 27548260Free PMC Article
Depoorter E, Bull MJ, Peeters C, Coenye T, Vandamme P, Mahenthiralingam E
Appl Microbiol Biotechnol 2016 Jun;100(12):5215-29. Epub 2016 Apr 26 doi: 10.1007/s00253-016-7520-x. PMID: 27115756
Haas DW, Kwara A, Richardson DM, Baker P, Papageorgiou I, Acosta EP, Morse GD, Court MH
J Antimicrob Chemother 2014 Aug;69(8):2175-82. Epub 2014 Apr 11 doi: 10.1093/jac/dku110. PMID: 24729586Free PMC Article
Foley TL, Rai G, Yasgar A, Daniel T, Baker HL, Attene-Ramos M, Kosa NM, Leister W, Burkart MD, Jadhav A, Simeonov A, Maloney DJ
J Med Chem 2014 Feb 13;57(3):1063-78. Epub 2014 Jan 22 doi: 10.1021/jm401752p. PMID: 24450337Free PMC Article
Castrillo M, García-Martínez J, Avalos J
Appl Environ Microbiol 2013 Apr;79(8):2777-88. Epub 2013 Feb 15 doi: 10.1128/AEM.03110-12. PMID: 23417004Free PMC Article

Diagnosis

Andalibi F, Fatahi-Bafghi M
Folia Microbiol (Praha) 2017 May;62(3):245-252. Epub 2017 Jan 20 doi: 10.1007/s12223-017-0491-1. PMID: 28105601
Bromley M, Johns A, Davies E, Fraczek M, Mabey Gilsenan J, Kurbatova N, Keays M, Kapushesky M, Gut M, Gut I, Denning DW, Bowyer P
PLoS One 2016;11(7):e0158724. Epub 2016 Jul 20 doi: 10.1371/journal.pone.0158724. PMID: 27438017Free PMC Article
Moloney NM, Owens RA, Doyle S
Expert Rev Proteomics 2016 Jul;13(7):635-49. Epub 2016 Jul 4 doi: 10.1080/14789450.2016.1203783. PMID: 27324303
Sánchez JA, Alfonso A, Leirós M, Alonso E, Rateb ME, Jaspars M, Houssen WE, Ebel R, Botana LM
Cell Physiol Biochem 2015;37(2):779-92. Epub 2015 Sep 11 doi: 10.1159/000430395. PMID: 26356268
Sekonyela R, Palmer JM, Bok JW, Jain S, Berthier E, Forseth R, Schroeder F, Keller NP
PLoS One 2013;8(5):e62591. Epub 2013 May 6 doi: 10.1371/journal.pone.0062591. PMID: 23671611Free PMC Article

Therapy

Bromley M, Johns A, Davies E, Fraczek M, Mabey Gilsenan J, Kurbatova N, Keays M, Kapushesky M, Gut M, Gut I, Denning DW, Bowyer P
PLoS One 2016;11(7):e0158724. Epub 2016 Jul 20 doi: 10.1371/journal.pone.0158724. PMID: 27438017Free PMC Article
Scotti L, Scotti MT
Curr Top Med Chem 2015;15(21):2239-52. PMID: 26059353
Djebli N, Fabre D, Boulenc X, Fabre G, Sultan E, Hurbin F
Drug Metab Dispos 2015 Apr;43(4):510-22. Epub 2015 Jan 21 doi: 10.1124/dmd.114.062596. PMID: 25609219
Haas DW, Kwara A, Richardson DM, Baker P, Papageorgiou I, Acosta EP, Morse GD, Court MH
J Antimicrob Chemother 2014 Aug;69(8):2175-82. Epub 2014 Apr 11 doi: 10.1093/jac/dku110. PMID: 24729586Free PMC Article
Ward BA, Gorski JC, Jones DR, Hall SD, Flockhart DA, Desta Z
J Pharmacol Exp Ther 2003 Jul;306(1):287-300. Epub 2003 Apr 3 doi: 10.1124/jpet.103.049601. PMID: 12676886

Prognosis

Gacek-Matthews A, Berger H, Sasaki T, Wittstein K, Gruber C, Lewis ZA, Strauss J
PLoS Genet 2016 Aug;12(8):e1006222. Epub 2016 Aug 22 doi: 10.1371/journal.pgen.1006222. PMID: 27548260Free PMC Article
Siitonen V, Räty K, Metsä-Ketelä M
Biochem Mol Biol Educ 2016 Sep 10;44(5):492-9. Epub 2016 May 18 doi: 10.1002/bmb.20970. PMID: 27192442
Haas DW, Kwara A, Richardson DM, Baker P, Papageorgiou I, Acosta EP, Morse GD, Court MH
J Antimicrob Chemother 2014 Aug;69(8):2175-82. Epub 2014 Apr 11 doi: 10.1093/jac/dku110. PMID: 24729586Free PMC Article
Breitling R, Achcar F, Takano E
ACS Synth Biol 2013 Jul 19;2(7):373-8. Epub 2013 May 20 doi: 10.1021/sb4000228. PMID: 23659212
Firn RD, Jones CG
Mol Microbiol 2000 Sep;37(5):989-94. PMID: 10972818

Clinical prediction guides

Gacek-Matthews A, Berger H, Sasaki T, Wittstein K, Gruber C, Lewis ZA, Strauss J
PLoS Genet 2016 Aug;12(8):e1006222. Epub 2016 Aug 22 doi: 10.1371/journal.pgen.1006222. PMID: 27548260Free PMC Article
Bromley M, Johns A, Davies E, Fraczek M, Mabey Gilsenan J, Kurbatova N, Keays M, Kapushesky M, Gut M, Gut I, Denning DW, Bowyer P
PLoS One 2016;11(7):e0158724. Epub 2016 Jul 20 doi: 10.1371/journal.pone.0158724. PMID: 27438017Free PMC Article
Haas DW, Kwara A, Richardson DM, Baker P, Papageorgiou I, Acosta EP, Morse GD, Court MH
J Antimicrob Chemother 2014 Aug;69(8):2175-82. Epub 2014 Apr 11 doi: 10.1093/jac/dku110. PMID: 24729586Free PMC Article
Breitling R, Achcar F, Takano E
ACS Synth Biol 2013 Jul 19;2(7):373-8. Epub 2013 May 20 doi: 10.1021/sb4000228. PMID: 23659212
Palmer JM, Keller NP
Curr Opin Microbiol 2010 Aug;13(4):431-6. Epub 2010 Jun 2 doi: 10.1016/j.mib.2010.04.008. PMID: 20627806Free PMC Article

Recent systematic reviews

Iegre J, Hayes MA, Thompson RA, Weidolf L, Isin EM
Drug Metab Dispos 2016 May;44(5):732-40. Epub 2016 Feb 11 doi: 10.1124/dmd.115.067850. PMID: 26868617
Pereira A, Maraschin M
J Ethnopharmacol 2015 Feb 3;160:149-63. Epub 2014 Nov 13 doi: 10.1016/j.jep.2014.11.008. PMID: 25449450
Stout SM, Cimino NM
Drug Metab Rev 2014 Feb;46(1):86-95. Epub 2013 Oct 25 doi: 10.3109/03602532.2013.849268. PMID: 24160757

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