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Fatigue

MedGen UID:
41971
Concept ID:
C0015672
Sign or Symptom
Synonyms: Tiredness
SNOMED CT: Fatigue (84229001); Tiredness (84229001); Lacking in energy (248274002); Lack of energy (248274002); Loss of energy (248274002); Weariness (84229001)
 
HPO: HP:0012378

Definition

Everyone feels tired now and then. Sometimes you may just want to stay in bed. But, after a good night's sleep, most people feel refreshed and ready to face a new day. If you continue to feel tired for weeks, it's time to see your doctor. He or she may be able to help you find out what's causing your fatigue and recommend ways to relieve it. Fatigue itself is not a disease. Medical problems, treatments, and personal habits can add to fatigue. These include. -Taking certain medicines, such as antidepressants, antihistamines, and medicines for nausea and pain. -Having medical treatments, like chemotherapy and radiation. -Recovering from major surgery. -Anxiety, stress, or depression. -Staying up too late. -Drinking too much alcohol or too many caffeinated drinks. -Pregnancy. One disorder that causes extreme fatigue is chronic fatigue syndrome (CFS). This fatigue is not the kind of tired feeling that goes away after you rest. Instead, it lasts a long time and limits your ability to do ordinary daily activities. NIH: National Institute on Aging.  [from MedlinePlus]

Term Hierarchy

Conditions with this feature

Lipomatosis dolorosa
MedGen UID:
1757
Concept ID:
C0001529
Disease or Syndrome
Adiposis dolorosa, also known as Dercum disease, is characterized by generalized obesity and pronounced, disabling, and chronic pain in the adipose tissue of the proximal extremities, trunk, pelvic area, and buttocks; the face and hands are usually spared. There are a number of associated symptoms, including multiple lipomas, generalized weakness, fatigue, sleep disturbances, constipation, and psychiatric abnormalities. It is 5 to 30 times more common in women than men, and usually presents between 35 and 50 years of age (summary by Campen et al., 2001; review by Hansson et al., 2012). Based on a review of the literature and studies of 111 patients, Hansson et al. (2012) proposed a classification of Dercum disease into 4 types: (I) generalized diffuse form without clear lipomas, (II) generalized nodular form with multiple lipomas, (III) localized nodular form, and (IV) juxtaarticular form with solitary fatty deposits near joints.
Myxedema
MedGen UID:
6506
Concept ID:
C0027145
Disease or Syndrome
A condition characterized by a dry, waxy type of swelling (EDEMA) with abnormal deposits of MUCOPOLYSACCHARIDES in the SKIN and other tissues. It is caused by a deficiency of THYROID HORMONES. The skin becomes puffy around the eyes and on the cheeks. The face is dull and expressionless with thickened nose and lips.
Familial hypokalemic alkalosis, Gullner type
MedGen UID:
78677
Concept ID:
C0268444
Disease or Syndrome
3-Methylglutaconic aciduria type 2
MedGen UID:
107893
Concept ID:
C0574083
Disease or Syndrome
Barth syndrome (BTHS) is an X-linked disease conventionally characterized by dilated cardiomyopathy (CMD) with endocardial fibroelastosis (EFE), a predominantly proximal skeletal myopathy, growth retardation, neutropenia, and organic aciduria, particularly excess of 3-methylglutaconic acid. Features of the disease that are less well known include hypertrophic cardiomyopathy, isolated left ventricular noncompaction (LVNC), ventricular arrhythmia, motor delay, poor appetite, fatigue and exercise intolerance, hypoglycemia, lactic acidosis, hyperammonemia, and dramatic late catch-up growth after growth delay throughout childhood (summary by Steward et al., 2010). For a phenotypic description and a discussion of genetic heterogeneity of 3-methylglutaconic aciduria, see MGCA type I (250950).
Analbuminemia
MedGen UID:
164210
Concept ID:
C0878666
Finding
Analbuminemia is a rare autosomal recessive disorder manifested by the presence of a very low amount of circulating serum albumin. Affected individuals have few clinical symptoms other than mild edema, hypotension, fatigue, and, occasionally, a peculiar lower body lipodystrophy (mainly in adult females). The most common biochemical finding is a gross hyperlipidemia, with a significant increase in the total and LDL cholesterol concentrations, but normal concentrations of HDL cholesterol and triglycerides. Analbuminemia often leads to fetal or neonatal death in sibs in families of analbuminemic subjects, which may explain the rarity of the trait (summary by Caridi et al., 2014).
Autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 3
MedGen UID:
373087
Concept ID:
C1836439
Disease or Syndrome
Progressive external ophthalmoplegia is characterized by multiple mitochondrial DNA deletions in skeletal muscle. The most common clinical features include adult onset of weakness of the external eye muscles and exercise intolerance. Patients with C10ORF2-linked adPEO may have other clinical features including proximal muscle weakness, ataxia, peripheral neuropathy, cardiomyopathy, cataracts, depression, and endocrine abnormalities (summary by Fratter et al., 2010). For a general phenotypic description and a discussion of genetic heterogeneity of autosomal dominant progressive external ophthalmoplegia, see PEOA1 (157640). PEO caused by mutations in the POLG gene are associated with more complicated phenotypes than those forms caused by mutations in the SLC25A4 (103220) or C10ORF2 genes (Lamantea et al., 2002).
Erythrocytosis, familial, 2
MedGen UID:
332974
Concept ID:
C1837915
Disease or Syndrome
Familial erythrocytosis-2 is an autosomal recessive disorder characterized by increased red blood cell mass, increased serum levels of erythropoietin (EPO; 133170), and normal oxygen affinity. Patients with ECYT2 carry a high risk for peripheral thrombosis and cerebrovascular events (Cario, 2005). Familial erythrocytosis-2 has features of both primary and secondary erythrocytosis. In addition to increased circulating levels of EPO, consistent with a secondary, extrinsic process, erythroid progenitors are also hypersensitive to EPO, consistent with a primary, intrinsic process (Prchal, 2005).
Pulmonary hypertension, primary, autosomal recessive
MedGen UID:
340354
Concept ID:
C1849552
Disease or Syndrome
Familial erythrocytosis, 1
MedGen UID:
343583
Concept ID:
C1851490
Disease or Syndrome
Familial erythrocytosis-1 is an autosomal dominant disorder characterized by increased serum red blood cell mass and hemoglobin concentration, hypersensitivity of erythroid progenitors to EPO, and low serum levels of EPO. There is no increase in platelets or leukocytes and the disorder does not progress to leukemia (Kralovics et al., 1998). Genetic Heterogeneity of Familial Erythrocytosis See also ECYT2 (263400), caused by mutation in the VHL gene (608537) on chromosome 3p25; ECYT3 (609820), caused by mutation in the EGLN1 gene (606425) on chromosome 1q42; and ECYT4 (611783), caused by mutation in the EPAS1 gene (603349) on chromosome 2p. Erythrocytosis may also be caused by somatic mutation in the JAK2 (147796) or the SH2B3 (605093) gene on chromosome 9p24 and 12q24, respectively. For a review of the genetics of congenital erythrocytosis, see Bento et al. (2014).
Cataract and cardiomyopathy
MedGen UID:
395228
Concept ID:
C1859317
Disease or Syndrome
Sengers syndrome is an autosomal recessive mitochondrial disorder characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, and lactic acidosis. Mental development is normal, but affected individuals may die early from cardiomyopathy (summary by Mayr et al., 2012). Skeletal muscle biopsies of 2 affected individuals showed severe mtDNA depletion (Calvo et al., 2012).
Congenital disorder of glycosylation type 1t
MedGen UID:
414536
Concept ID:
C2752015
Disease or Syndrome
Congenital disorder of glycosylation type It (CDG1T) is an autosomal recessive disorder characterized by a wide range of clinical manifestations and severity. The most common features include cleft lip and bifid uvula, apparent at birth, followed by hepatopathy, intermittent hypoglycemia, short stature, and exercise intolerance, often accompanied by increased serum creatine kinase. Less common features include rhabdomyolysis, dilated cardiomyopathy, and hypogonadotropic hypogonadism (summary by Tegtmeyer et al., 2014). For a discussion of the classification of CDGs, see CDG1A (212065).
Limb-girdle muscular dystrophy-dystroglycanopathy, type C3
MedGen UID:
461767
Concept ID:
C3150417
Disease or Syndrome
MDDGC3 is a rare form of autosomal recessive limb-girdle muscular dystrophy with normal cognition (Clement et al., 2008). It is part of a group of similar disorders resulting from defective glycosylation of alpha-dystroglycan (DAG1; 128239), collectively known as 'dystroglycanopathies' (Godfrey et al., 2007). For a discussion of genetic heterogeneity of muscular dystrophy-dystroglycanopathy type C, see MDDGC1 (609308).
Paroxysmal nocturnal hemoglobinuria 2
MedGen UID:
815699
Concept ID:
C3809369
Disease or Syndrome
Glucocorticoid resistance, generalized
MedGen UID:
798686
Concept ID:
CN205763
Disease or Syndrome
Generalized glucocorticoid resistance is an autosomal dominant disease characterized by increased plasma cortisol concentration and high urinary free cortisol, resistance to adrenal suppression by dexamethasone, and the absence of clinical stigmata of Cushing syndrome. The clinical expression of the disease is variable. Common features include hypoglycemia, hypertension, and metabolic alkalosis. In females, overproduction of adrenal androgens has been associated with infertility, male-pattern baldness, hirsutism, and menstrual irregularities. Other features include chronic fatigue and profound anxiety (summary by Chrousos et al., 1983; Donner et al., 2013).

Recent clinical studies

Etiology

Filtness AJ, Naweed A
Appl Ergon 2017 Apr;60:12-21. Epub 2016 Nov 4 doi: 10.1016/j.apergo.2016.10.009. PMID: 28166870
Kwon OY, Ahn HS, Kim HJ
Seizure 2017 Feb;45:151-159. Epub 2016 Nov 16 doi: 10.1016/j.seizure.2016.11.006. PMID: 28063374
Levis B, Kwakkenbos L, Hudson M, Baron M, Thombs BD; and the Canadian Scleroderma Research Group.
Clin Rheumatol 2017 Feb;36(2):373-379. Epub 2016 Dec 10 doi: 10.1007/s10067-016-3501-9. PMID: 27943045
Rogers DC, Dittner AJ, Rimes KA, Chalder T
Br J Clin Psychol 2017 Mar;56(1):33-52. Epub 2016 Dec 5 doi: 10.1111/bjc.12119. PMID: 27918087
Menting J, Nikolaus S, van der Veld WM, Goedendorp MM, Tack CJ, Knoop H
Diabetes Res Clin Pract 2016 Nov;121:127-134. Epub 2016 Sep 21 doi: 10.1016/j.diabres.2016.09.011. PMID: 27710819

Diagnosis

Baussard L, Stoebner-Delbarre A, Bonnabel L, Huteau ME, Gastou A, Cousson-Gélie F
Eur J Oncol Nurs 2017 Feb;26:42-48. Epub 2016 Dec 19 doi: 10.1016/j.ejon.2016.12.004. PMID: 28069151
Levis B, Kwakkenbos L, Hudson M, Baron M, Thombs BD; and the Canadian Scleroderma Research Group.
Clin Rheumatol 2017 Feb;36(2):373-379. Epub 2016 Dec 10 doi: 10.1007/s10067-016-3501-9. PMID: 27943045
Rogers DC, Dittner AJ, Rimes KA, Chalder T
Br J Clin Psychol 2017 Mar;56(1):33-52. Epub 2016 Dec 5 doi: 10.1111/bjc.12119. PMID: 27918087
Menting J, Nikolaus S, van der Veld WM, Goedendorp MM, Tack CJ, Knoop H
Diabetes Res Clin Pract 2016 Nov;121:127-134. Epub 2016 Sep 21 doi: 10.1016/j.diabres.2016.09.011. PMID: 27710819
Simpson S Jr, Tan H, Otahal P, Taylor B, Ponsonby AL, Lucas RM, Blizzard L, Valery PC, Lechner-Scott J, Shaw C, Williams D; Ausimmune/AusLong Investigators Group., van der Mei I
Acta Neurol Scand 2016 Dec;134(6):403-413. Epub 2016 Jan 12 doi: 10.1111/ane.12554. PMID: 26756925

Therapy

Lipsett A, Barrett S, Haruna F, Mustian K, O'Donovan A
Breast 2017 Apr;32:144-155. Epub 2017 Feb 9 doi: 10.1016/j.breast.2017.02.002. PMID: 28189100
Bach HV, Kim J, Myung SK, Cho YA
J Korean Med Sci 2016 Dec;31(12):1879-1886. doi: 10.3346/jkms.2016.31.12.1879. PMID: 27822924Free PMC Article
Spadaro S, Capuzzo M, Valpiani G, Bertacchini S, Ragazzi R, Dalla Corte F, Terranova S, Marangoni E, Volta CA
Health Qual Life Outcomes 2016 Oct 18;14(1):148. doi: 10.1186/s12955-016-0554-z. PMID: 27756403Free PMC Article
Lee N, Lee SH, Yoo HR, Yoo HS
J Altern Complement Med 2016 Nov;22(11):859-864. Epub 2016 Oct 18 doi: 10.1089/acm.2016.0057. PMID: 27754709
Avaux M, Hoellinger P, Nieuwland-Husson S, Fraselle V, Depresseux G, Houssiau FA
Acta Clin Belg 2016 Dec;71(6):403-406. Epub 2016 Jul 1 doi: 10.1080/17843286.2016.1200824. PMID: 27377292

Prognosis

Kantorová E, Poláček H, Bittšanský M, Baranovičová E, Hnilicová P, Čierny D, Sivák Š, Nosáľ V, Zeleňák K, Kurča E
Neurol Res 2017 Apr;39(4):323-330. Epub 2017 Feb 13 doi: 10.1080/01616412.2016.1275460. PMID: 28191860
Menting J, Nikolaus S, van der Veld WM, Goedendorp MM, Tack CJ, Knoop H
Diabetes Res Clin Pract 2016 Nov;121:127-134. Epub 2016 Sep 21 doi: 10.1016/j.diabres.2016.09.011. PMID: 27710819
van der Sluijs BM, Knoop H, Bleijenberg G, van Engelen BG, Voermans NC
Neuromuscul Disord 2016 Mar;26(3):221-6. Epub 2016 Feb 13 doi: 10.1016/j.nmd.2015.12.009. PMID: 26948710
Peters ME, Goedendorp MM, Verhagen CA, Bleijenberg G, van der Graaf WT
Support Care Cancer 2016 Mar;24(3):1349-55. Epub 2015 Sep 3 doi: 10.1007/s00520-015-2909-0. PMID: 26335403Free PMC Article
Rodrigues AR, Trufelli DC, Fonseca F, de Paula LC, Giglio AD
Am J Hosp Palliat Care 2016 Dec;33(10):942-947. Epub 2015 Aug 30 doi: 10.1177/1049909115603055. PMID: 26324072

Clinical prediction guides

Vinnikov D, Blanc PD, Alilin A, Zutler M, Holty JC
Health Qual Life Outcomes 2017 Mar 14;15(1):48. doi: 10.1186/s12955-017-0624-x. PMID: 28288646Free PMC Article
Kantorová E, Poláček H, Bittšanský M, Baranovičová E, Hnilicová P, Čierny D, Sivák Š, Nosáľ V, Zeleňák K, Kurča E
Neurol Res 2017 Apr;39(4):323-330. Epub 2017 Feb 13 doi: 10.1080/01616412.2016.1275460. PMID: 28191860
Kwon OY, Ahn HS, Kim HJ
Seizure 2017 Feb;45:151-159. Epub 2016 Nov 16 doi: 10.1016/j.seizure.2016.11.006. PMID: 28063374
Levis B, Kwakkenbos L, Hudson M, Baron M, Thombs BD; and the Canadian Scleroderma Research Group.
Clin Rheumatol 2017 Feb;36(2):373-379. Epub 2016 Dec 10 doi: 10.1007/s10067-016-3501-9. PMID: 27943045
Menting J, Nikolaus S, van der Veld WM, Goedendorp MM, Tack CJ, Knoop H
Diabetes Res Clin Pract 2016 Nov;121:127-134. Epub 2016 Sep 21 doi: 10.1016/j.diabres.2016.09.011. PMID: 27710819

Recent systematic reviews

Lipsett A, Barrett S, Haruna F, Mustian K, O'Donovan A
Breast 2017 Apr;32:144-155. Epub 2017 Feb 9 doi: 10.1016/j.breast.2017.02.002. PMID: 28189100
Kwon OY, Ahn HS, Kim HJ
Seizure 2017 Feb;45:151-159. Epub 2016 Nov 16 doi: 10.1016/j.seizure.2016.11.006. PMID: 28063374
Jensen Ø, Bernklev T, Jelsness-Jørgensen LP
Diabetes Res Clin Pract 2017 Jan;123:63-74. Epub 2016 Nov 10 doi: 10.1016/j.diabres.2016.11.002. PMID: 28002753
Bach HV, Kim J, Myung SK, Cho YA
J Korean Med Sci 2016 Dec;31(12):1879-1886. doi: 10.3346/jkms.2016.31.12.1879. PMID: 27822924Free PMC Article
Cadegiani FA, Kater CE
BMC Endocr Disord 2016 Aug 24;16(1):48. doi: 10.1186/s12902-016-0128-4. PMID: 27557747Free PMC Article

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