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Leiomyosarcoma

MedGen UID:
9711
Concept ID:
C0023269
Neoplastic Process
Synonyms: Leiomyosarcomas
SNOMED CT: LMS - Leiomyosarcoma (51549004); Leiomyosarcoma, no subtype (51549004); Leiomyosarcoma (443719001); Leiomyosarcoma (51549004)
 
HPO: HP:0100243
Orphanet: ORPHA64720

Definition

A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865) [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Leiomyosarcoma
Follow this link to review classifications for Leiomyosarcoma in Orphanet.

Recent clinical studies

Etiology

Littell RD, Tucker LY, Raine-Bennett T, Palen TE, Zaritsky E, Neugebauer R, Embry-Schubert J, Lentz SE
Gynecol Oncol 2017 Oct;147(1):11-17. Epub 2017 Jul 24 doi: 10.1016/j.ygyno.2017.07.122. PMID: 28747255
Seagle BL, Sobecki-Rausch J, Strohl AE, Shilpi A, Grace A, Shahabi S
Gynecol Oncol 2017 Apr;145(1):61-70. Epub 2017 Mar 15 doi: 10.1016/j.ygyno.2017.02.012. PMID: 28317559
Sahli N, Khmou M, Khalil J, Elmajjaoui S, El Khannoussi B, Kebdani T, Elkacemi H, Benjaafar N
J Med Case Rep 2016 Sep 15;10(1):249. doi: 10.1186/s13256-016-1047-8. PMID: 27633779Free PMC Article
Skorstad M, Kent A, Lieng M
Acta Obstet Gynecol Scand 2016 Nov;95(11):1228-1234. doi: 10.1111/aogs.13008. PMID: 27564388
Rodriguez AM, Asoglu MR, Sak ME, Tan A, Borahay MA, Kilic GS
Eur J Obstet Gynecol Reprod Biol 2016 Feb;197:31-5. Epub 2015 Nov 28 doi: 10.1016/j.ejogrb.2015.11.009. PMID: 26699101

Diagnosis

Littell RD, Tucker LY, Raine-Bennett T, Palen TE, Zaritsky E, Neugebauer R, Embry-Schubert J, Lentz SE
Gynecol Oncol 2017 Oct;147(1):11-17. Epub 2017 Jul 24 doi: 10.1016/j.ygyno.2017.07.122. PMID: 28747255
Seagle BL, Sobecki-Rausch J, Strohl AE, Shilpi A, Grace A, Shahabi S
Gynecol Oncol 2017 Apr;145(1):61-70. Epub 2017 Mar 15 doi: 10.1016/j.ygyno.2017.02.012. PMID: 28317559
Ricci S, Stone RL, Fader AN
Gynecol Oncol 2017 Apr;145(1):208-216. Epub 2017 Feb 13 doi: 10.1016/j.ygyno.2017.02.019. PMID: 28209496
Sahli N, Khmou M, Khalil J, Elmajjaoui S, El Khannoussi B, Kebdani T, Elkacemi H, Benjaafar N
J Med Case Rep 2016 Sep 15;10(1):249. doi: 10.1186/s13256-016-1047-8. PMID: 27633779Free PMC Article
Skorstad M, Kent A, Lieng M
Acta Obstet Gynecol Scand 2016 Nov;95(11):1228-1234. doi: 10.1111/aogs.13008. PMID: 27564388

Therapy

Littell RD, Tucker LY, Raine-Bennett T, Palen TE, Zaritsky E, Neugebauer R, Embry-Schubert J, Lentz SE
Gynecol Oncol 2017 Oct;147(1):11-17. Epub 2017 Jul 24 doi: 10.1016/j.ygyno.2017.07.122. PMID: 28747255
Vincenzi B, Stacchiotti S, Collini P, Pantano F, Rabitti C, Perrone G, Iuliani M, Baldi A, Badalamenti G, Sanfilippo R, Santini D, Muda AO, Gronchi A, Casali P, Dei Tos AP, Tonini G
Br J Cancer 2017 Jul 25;117(3):340-346. Epub 2017 Jun 22 doi: 10.1038/bjc.2017.187. PMID: 28641307Free PMC Article
Ricci S, Stone RL, Fader AN
Gynecol Oncol 2017 Apr;145(1):208-216. Epub 2017 Feb 13 doi: 10.1016/j.ygyno.2017.02.019. PMID: 28209496
Agarwal N, Hansberry DR, Kavi A, Agarwal P, Baisre A, Goldstein IM
World Neurosurg 2017 Mar;99:484-490. Epub 2016 Dec 21 doi: 10.1016/j.wneu.2016.12.035. PMID: 28011357
Laranjinha I, Matias P, Jorge C, Birne R, Weigert A, Adragão T, Bruges M, Cabrera RA, Cassis J, Ramos S, Nogueira A, Godinho J, Messias H, Machado D
Transplant Proc 2016 Sep;48(7):2379-2383. doi: 10.1016/j.transproceed.2016.06.005. PMID: 27742302

Prognosis

Seagle BL, Sobecki-Rausch J, Strohl AE, Shilpi A, Grace A, Shahabi S
Gynecol Oncol 2017 Apr;145(1):61-70. Epub 2017 Mar 15 doi: 10.1016/j.ygyno.2017.02.012. PMID: 28317559
Ricci S, Stone RL, Fader AN
Gynecol Oncol 2017 Apr;145(1):208-216. Epub 2017 Feb 13 doi: 10.1016/j.ygyno.2017.02.019. PMID: 28209496
Agarwal N, Hansberry DR, Kavi A, Agarwal P, Baisre A, Goldstein IM
World Neurosurg 2017 Mar;99:484-490. Epub 2016 Dec 21 doi: 10.1016/j.wneu.2016.12.035. PMID: 28011357
Sahli N, Khmou M, Khalil J, Elmajjaoui S, El Khannoussi B, Kebdani T, Elkacemi H, Benjaafar N
J Med Case Rep 2016 Sep 15;10(1):249. doi: 10.1186/s13256-016-1047-8. PMID: 27633779Free PMC Article
Tajima S, Waki M, Fukuyama M
Med Mol Morphol 2016 Dec;49(4):238-242. Epub 2015 Apr 25 doi: 10.1007/s00795-015-0103-6. PMID: 25910609

Clinical prediction guides

Littell RD, Tucker LY, Raine-Bennett T, Palen TE, Zaritsky E, Neugebauer R, Embry-Schubert J, Lentz SE
Gynecol Oncol 2017 Oct;147(1):11-17. Epub 2017 Jul 24 doi: 10.1016/j.ygyno.2017.07.122. PMID: 28747255
Seagle BL, Sobecki-Rausch J, Strohl AE, Shilpi A, Grace A, Shahabi S
Gynecol Oncol 2017 Apr;145(1):61-70. Epub 2017 Mar 15 doi: 10.1016/j.ygyno.2017.02.012. PMID: 28317559
Ricci S, Stone RL, Fader AN
Gynecol Oncol 2017 Apr;145(1):208-216. Epub 2017 Feb 13 doi: 10.1016/j.ygyno.2017.02.019. PMID: 28209496
Lu B, Shi H, Zhang X
Hum Pathol 2017 Jan;59:139-146. Epub 2016 Oct 4 doi: 10.1016/j.humpath.2016.09.014. PMID: 27717885
Tajima S, Waki M, Fukuyama M
Med Mol Morphol 2016 Dec;49(4):238-242. Epub 2015 Apr 25 doi: 10.1007/s00795-015-0103-6. PMID: 25910609

Recent systematic reviews

Yang Y, Ma L, Li L, Liu H
Medicine (Baltimore) 2017 Mar;96(9):e6227. doi: 10.1097/MD.0000000000006227. PMID: 28248883Free PMC Article
Ricci S, Stone RL, Fader AN
Gynecol Oncol 2017 Apr;145(1):208-216. Epub 2017 Feb 13 doi: 10.1016/j.ygyno.2017.02.019. PMID: 28209496
Wen KC, Horng HC, Wang PH, Chen YJ, Yen MS, Ng HT; Taiwan Association of Gynecology Systematic Review Group.
Taiwan J Obstet Gynecol 2016 Aug;55(4):463-71. doi: 10.1016/j.tjog.2016.04.033. PMID: 27590365
Bogani G, Fucà G, Maltese G, Ditto A, Martinelli F, Signorelli M, Chiappa V, Scaffa C, Sabatucci I, Lecce F, Raspagliesi F, Lorusso D
Gynecol Oncol 2016 Nov;143(2):443-447. Epub 2016 Jul 29 doi: 10.1016/j.ygyno.2016.07.110. PMID: 27481579
Wang JG, Cui L, Jiang T, Li YJ, Wei ZM
Asian Cardiovasc Thorac Ann 2015 Jun;23(5):623-30. Epub 2015 Mar 3 doi: 10.1177/0218492315574197. PMID: 25740020

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