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Bupropion hydrochloride

MedGen UID:
152171
Concept ID:
C0700563
Organic Chemical; Pharmacologic Substance
Synonyms: Bupropion Hydrochloride
SNOMED CT: Bupropion hydrochloride (395733003); Bupropion hydrochloride (412594009)
 

Definition

The hydrochloride salt of an aminoketone antidepressant. The molecular mechanism of the antidepressant effect of bupropion is unknown. This agent does not inhibit monoamine oxidase and, compared to classical tricyclic antidepressants, is a weak blocker of the neuronal uptake of serotonin and norepinephrine. Buproprion also weakly inhibits the neuronal re-uptake of dopamine. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBupropion hydrochloride

Recent clinical studies

Etiology

Shoptaw S, Heinzerling KG, Rotheram-Fuller E, Kao UH, Wang PC, Bholat MA, Ling W
J Addict Dis 2008;27(1):13-23. doi: 10.1300/J069v27n01_02. PMID: 18551884
Dalsgareth OJ, Hansen NC, Søes-Petersen U, Evald T, Høegholm A, Barber J, Vestbo J
Nicotine Tob Res 2004 Feb;6(1):55-61. doi: 10.1080/14622200310001656867. PMID: 14982688
David SP, Niaura R, Papandonatos GD, Shadel WG, Burkholder GJ, Britt DM, Day A, Stumpff J, Hutchison K, Murphy M, Johnstone E, Griffiths SE, Walton RT
Nicotine Tob Res 2003 Dec;5(6):935-42. doi: 10.1080/14622200310001615295. PMID: 14668077
Nichols MR
Clin Excell Nurse Pract 1999 Nov;3(6):317-22. PMID: 10865568
Conners CK, Casat CD, Gualtieri CT, Weller E, Reader M, Reiss A, Weller RA, Khayrallah M, Ascher J
J Am Acad Child Adolesc Psychiatry 1996 Oct;35(10):1314-21. doi: 10.1097/00004583-199610000-00018. PMID: 8885585

Diagnosis

Symes RJ, Etminan M, Mikelberg FS
JAMA Ophthalmol 2015 Oct;133(10):1187-9. doi: 10.1001/jamaophthalmol.2015.2180. PMID: 26158444
Blumenthal SR, Castro VM, Clements CC, Rosenfield HR, Murphy SN, Fava M, Weilburg JB, Erb JL, Churchill SE, Kohane IS, Smoller JW, Perlis RH
JAMA Psychiatry 2014 Aug;71(8):889-96. doi: 10.1001/jamapsychiatry.2014.414. PMID: 24898363
Seo HJ, Lee BC, Seok JH, Jeon HJ, Paik JW, Kim W, Kwak KP, Han C, Lee KU, Pae CU
Pharmacopsychiatry 2013 Sep;46(6):221-6. Epub 2013 Aug 20 doi: 10.1055/s-0033-1353171. PMID: 23963965
Muramoto ML, Leischow SJ, Sherrill D, Matthews E, Strayer LJ
Arch Pediatr Adolesc Med 2007 Nov;161(11):1068-74. doi: 10.1001/archpedi.161.11.1068. PMID: 17984409
Conners CK, Casat CD, Gualtieri CT, Weller E, Reader M, Reiss A, Weller RA, Khayrallah M, Ascher J
J Am Acad Child Adolesc Psychiatry 1996 Oct;35(10):1314-21. doi: 10.1097/00004583-199610000-00018. PMID: 8885585

Therapy

Khan SR, Berendt RT, Ellison CD, Ciavarella AB, Asafu-Adjaye E, Khan MA, Faustino PJ
Profiles Drug Subst Excip Relat Methodol 2016;41:1-30. Epub 2016 Feb 17 doi: 10.1016/bs.podrm.2015.12.001. PMID: 26940167
Seo HJ, Lee BC, Seok JH, Jeon HJ, Paik JW, Kim W, Kwak KP, Han C, Lee KU, Pae CU
Pharmacopsychiatry 2013 Sep;46(6):221-6. Epub 2013 Aug 20 doi: 10.1055/s-0033-1353171. PMID: 23963965
Shoptaw S, Heinzerling KG, Rotheram-Fuller E, Kao UH, Wang PC, Bholat MA, Ling W
J Addict Dis 2008;27(1):13-23. doi: 10.1300/J069v27n01_02. PMID: 18551884
Dalsgareth OJ, Hansen NC, Søes-Petersen U, Evald T, Høegholm A, Barber J, Vestbo J
Nicotine Tob Res 2004 Feb;6(1):55-61. doi: 10.1080/14622200310001656867. PMID: 14982688
David SP, Niaura R, Papandonatos GD, Shadel WG, Burkholder GJ, Britt DM, Day A, Stumpff J, Hutchison K, Murphy M, Johnstone E, Griffiths SE, Walton RT
Nicotine Tob Res 2003 Dec;5(6):935-42. doi: 10.1080/14622200310001615295. PMID: 14668077

Prognosis

Zhou C, Wu L, Liu Q, An H, Jiang B, Zuo F, Zhang L, He Y
Medicine (Baltimore) 2017 Oct;96(42):e7459. doi: 10.1097/MD.0000000000007459. PMID: 29049178Free PMC Article
Shoptaw S, Heinzerling KG, Rotheram-Fuller E, Kao UH, Wang PC, Bholat MA, Ling W
J Addict Dis 2008;27(1):13-23. doi: 10.1300/J069v27n01_02. PMID: 18551884
Fossati R, Apolone G, Negri E, Compagnoni A, La Vecchia C, Mangano S, Clivio L, Garattini S; General Practice Tobacco Cessation Investigators Group.
Arch Intern Med 2007 Sep 10;167(16):1791-7. doi: 10.1001/archinte.167.16.1791. PMID: 17846399
Lustman PJ, Williams MM, Sayuk GS, Nix BD, Clouse RE
Diabetes Care 2007 Mar;30(3):459-66. doi: 10.2337/dc06-1769. PMID: 17327305
Nides M, Oncken C, Gonzales D, Rennard S, Watsky EJ, Anziano R, Reeves KR
Arch Intern Med 2006 Aug 14-28;166(15):1561-8. doi: 10.1001/archinte.166.15.1561. PMID: 16908788

Clinical prediction guides

Zhou C, Wu L, Liu Q, An H, Jiang B, Zuo F, Zhang L, He Y
Medicine (Baltimore) 2017 Oct;96(42):e7459. doi: 10.1097/MD.0000000000007459. PMID: 29049178Free PMC Article
Symes RJ, Etminan M, Mikelberg FS
JAMA Ophthalmol 2015 Oct;133(10):1187-9. doi: 10.1001/jamaophthalmol.2015.2180. PMID: 26158444
Blumenthal SR, Castro VM, Clements CC, Rosenfield HR, Murphy SN, Fava M, Weilburg JB, Erb JL, Churchill SE, Kohane IS, Smoller JW, Perlis RH
JAMA Psychiatry 2014 Aug;71(8):889-96. doi: 10.1001/jamapsychiatry.2014.414. PMID: 24898363
Akdemir HU, Calışkan F, Duran L, Katı C, Güngörer B, Ocak M
J Formos Med Assoc 2014 Oct;113(10):754-5. Epub 2014 Mar 11 doi: 10.1016/j.jfma.2014.01.019. PMID: 24636552
Seo HJ, Lee BC, Seok JH, Jeon HJ, Paik JW, Kim W, Kwak KP, Han C, Lee KU, Pae CU
Pharmacopsychiatry 2013 Sep;46(6):221-6. Epub 2013 Aug 20 doi: 10.1055/s-0033-1353171. PMID: 23963965

Recent systematic reviews

Caixàs A, Albert L, Capel I, Rigla M
Drug Des Devel Ther 2014;8:1419-27. Epub 2014 Sep 18 doi: 10.2147/DDDT.S55587. PMID: 25258511Free PMC Article
Rigotti NA, Munafo MR, Stead LF
Arch Intern Med 2008 Oct 13;168(18):1950-60. doi: 10.1001/archinte.168.18.1950. PMID: 18852395Free PMC Article
Revicki DA, Siddique J, Frank L, Chung JY, Green BL, Krupnick J, Prasad M, Miranda J
Arch Gen Psychiatry 2005 Aug;62(8):868-75. doi: 10.1001/archpsyc.62.8.868. PMID: 16061764
Wagena EJ, Knipschild P, Zeegers MP
Addiction 2005 Mar;100(3):317-26. doi: 10.1111/j.1360-0443.2005.00998.x. PMID: 15733245
Zwar N, Richmond R
Aust Fam Physician 2002 May;31(5):443-7. PMID: 12043548

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