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Vitamin K deficiency

MedGen UID:
22672
Concept ID:
C0042880
Disease or Syndrome
Synonyms: Deficiencies, Vitamin K; Deficiency, Vitamin K; Vitamin K Deficiencies; Vitamin K Deficiency
SNOMED CT: Deficiency of vitamin K (52675005); Vitamin K deficiency (52675005)
 
HPO: HP:0011892

Definition

Deficiency of vitamin K. It may lead to bleeding, manifested with ecchymoses, petechiae, and hematomas. In infants it may cause hemorrhagic disease of newborn with intracranial and retroperitoneal bleeding. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVitamin K deficiency

Conditions with this feature

Celiac disease
MedGen UID:
3291
Concept ID:
C0007570
Disease or Syndrome
Celiac disease is a systemic autoimmune disease that can be associated with gastrointestinal findings (diarrhea, weight loss, abdominal pain, anorexia, lactose intolerance, abdominal distention, and irritability) and/or highly variable non-gastrointestinal findings (iron deficiency anemia, dermatitis herpetiformis, chronic fatigue, joint pain/inflammation, migraines, depression, attention-deficit disorder, epilepsy, osteoporosis/osteopenia, infertility and/or recurrent fetal loss, vitamin deficiencies, short stature, failure to thrive, delayed puberty, dental enamel defects, and autoimmune disorders). Classic celiac disease, characterized by mild to severe gastrointestinal symptoms, is less common than non-classic celiac disease, characterized by absence of gastrointestinal symptoms.
Chondrodysplasia punctata, autosomal dominant
MedGen UID:
303176
Concept ID:
C1442935
Disease or Syndrome
Hypercholanemia, familial
MedGen UID:
334689
Concept ID:
C1843139
Disease or Syndrome

Recent clinical studies

Etiology

Schulte R, Jordan LC, Morad A, Naftel RP, Wellons JC 3rd, Sidonio R
Pediatr Neurol 2014 Jun;50(6):564-8. Epub 2014 Feb 28 doi: 10.1016/j.pediatrneurol.2014.02.013. PMID: 24842255
Nowak JK, Grzybowska-Chlebowczyk U, Landowski P, Szaflarska-Poplawska A, Klincewicz B, Adamczak D, Banasiewicz T, Plawski A, Walkowiak J
Sci Rep 2014 Apr 24;4:4768. doi: 10.1038/srep04768. PMID: 24759680Free PMC Article
Misra D, Booth SL, Tolstykh I, Felson DT, Nevitt MC, Lewis CE, Torner J, Neogi T
Am J Med 2013 Mar;126(3):243-8. doi: 10.1016/j.amjmed.2012.10.011. PMID: 23410565Free PMC Article
Dituri F, Buonocore G, Pietravalle A, Naddeo F, Cortesi M, Pasqualetti P, Tataranno ML, Agostino R
J Matern Fetal Neonatal Med 2012 Sep;25(9):1660-3. Epub 2012 Feb 24 doi: 10.3109/14767058.2012.657273. PMID: 22280352
Kasatkar P, Shetty S, Ghosh K
Blood Coagul Fibrinolysis 2010 Sep;21(6):608-10. doi: 10.1097/MBC.0b013e32833b645c. PMID: 20531166

Diagnosis

Shigemi D, Nakanishi K, Miyazaki M, Shibata Y, Suzuki S
J Nippon Med Sch 2015;82(1):54-8. doi: 10.1272/jnms.82.54. PMID: 25797877
Urano A, Hotta M, Ohwada R, Araki M
Clin Nutr 2015 Jun;34(3):443-8. Epub 2014 May 28 doi: 10.1016/j.clnu.2014.04.016. PMID: 24909585
Eichinger S
Hamostaseologie 2014;34(3):237-8. Epub 2014 Jun 12 doi: 10.5482/HAMO-14-03-0019. PMID: 24919584
Dituri F, Buonocore G, Pietravalle A, Naddeo F, Cortesi M, Pasqualetti P, Tataranno ML, Agostino R
J Matern Fetal Neonatal Med 2012 Sep;25(9):1660-3. Epub 2012 Feb 24 doi: 10.3109/14767058.2012.657273. PMID: 22280352
Kasatkar P, Shetty S, Ghosh K
Blood Coagul Fibrinolysis 2010 Sep;21(6):608-10. doi: 10.1097/MBC.0b013e32833b645c. PMID: 20531166

Therapy

Shigemi D, Nakanishi K, Miyazaki M, Shibata Y, Suzuki S
J Nippon Med Sch 2015;82(1):54-8. doi: 10.1272/jnms.82.54. PMID: 25797877
Eichinger S
Hamostaseologie 2014;34(3):237-8. Epub 2014 Jun 12 doi: 10.5482/HAMO-14-03-0019. PMID: 24919584
Schulte R, Jordan LC, Morad A, Naftel RP, Wellons JC 3rd, Sidonio R
Pediatr Neurol 2014 Jun;50(6):564-8. Epub 2014 Feb 28 doi: 10.1016/j.pediatrneurol.2014.02.013. PMID: 24842255
Nowak JK, Grzybowska-Chlebowczyk U, Landowski P, Szaflarska-Poplawska A, Klincewicz B, Adamczak D, Banasiewicz T, Plawski A, Walkowiak J
Sci Rep 2014 Apr 24;4:4768. doi: 10.1038/srep04768. PMID: 24759680Free PMC Article
Kasatkar P, Shetty S, Ghosh K
Blood Coagul Fibrinolysis 2010 Sep;21(6):608-10. doi: 10.1097/MBC.0b013e32833b645c. PMID: 20531166

Prognosis

Schulte R, Jordan LC, Morad A, Naftel RP, Wellons JC 3rd, Sidonio R
Pediatr Neurol 2014 Jun;50(6):564-8. Epub 2014 Feb 28 doi: 10.1016/j.pediatrneurol.2014.02.013. PMID: 24842255
Nowak JK, Grzybowska-Chlebowczyk U, Landowski P, Szaflarska-Poplawska A, Klincewicz B, Adamczak D, Banasiewicz T, Plawski A, Walkowiak J
Sci Rep 2014 Apr 24;4:4768. doi: 10.1038/srep04768. PMID: 24759680Free PMC Article
Dituri F, Buonocore G, Pietravalle A, Naddeo F, Cortesi M, Pasqualetti P, Tataranno ML, Agostino R
J Matern Fetal Neonatal Med 2012 Sep;25(9):1660-3. Epub 2012 Feb 24 doi: 10.3109/14767058.2012.657273. PMID: 22280352
Westenfeld R, Krueger T, Schlieper G, Cranenburg EC, Magdeleyns EJ, Heidenreich S, Holzmann S, Vermeer C, Jahnen-Dechent W, Ketteler M, Floege J, Schurgers LJ
Am J Kidney Dis 2012 Feb;59(2):186-95. Epub 2011 Dec 9 doi: 10.1053/j.ajkd.2011.10.041. PMID: 22169620
Takahashi D, Shirahata A, Itoh S, Takahashi Y, Nishiguchi T, Matsuda Y
Pediatr Int 2011 Dec;53(6):897-901. doi: 10.1111/j.1442-200X.2011.03392.x. PMID: 21518125

Clinical prediction guides

Urano A, Hotta M, Ohwada R, Araki M
Clin Nutr 2015 Jun;34(3):443-8. Epub 2014 May 28 doi: 10.1016/j.clnu.2014.04.016. PMID: 24909585
Nowak JK, Grzybowska-Chlebowczyk U, Landowski P, Szaflarska-Poplawska A, Klincewicz B, Adamczak D, Banasiewicz T, Plawski A, Walkowiak J
Sci Rep 2014 Apr 24;4:4768. doi: 10.1038/srep04768. PMID: 24759680Free PMC Article
Miyao M, Abiru H, Ozeki M, Kotani H, Tsuruyama T, Kobayashi N, Omae T, Osamura T, Tamaki K
Forensic Sci Int 2012 Sep 10;221(1-3):e25-9. Epub 2012 May 16 doi: 10.1016/j.forsciint.2012.04.018. PMID: 22607980
Dituri F, Buonocore G, Pietravalle A, Naddeo F, Cortesi M, Pasqualetti P, Tataranno ML, Agostino R
J Matern Fetal Neonatal Med 2012 Sep;25(9):1660-3. Epub 2012 Feb 24 doi: 10.3109/14767058.2012.657273. PMID: 22280352
Westenfeld R, Krueger T, Schlieper G, Cranenburg EC, Magdeleyns EJ, Heidenreich S, Holzmann S, Vermeer C, Jahnen-Dechent W, Ketteler M, Floege J, Schurgers LJ
Am J Kidney Dis 2012 Feb;59(2):186-95. Epub 2011 Dec 9 doi: 10.1053/j.ajkd.2011.10.041. PMID: 22169620

Recent systematic reviews

Shah K, Gleason L, Villareal DT
J Nutr Gerontol Geriatr 2014;33(1):10-22. doi: 10.1080/21551197.2014.875818. PMID: 24597993
Jagannath VA, Fedorowicz Z, Thaker V, Chang AB
Cochrane Database Syst Rev 2013 Apr 30;(4):CD008482. doi: 10.1002/14651858.CD008482.pub3. PMID: 23633357
Yadav A, Carey EJ
Nutr Clin Pract 2013 Feb;28(1):52-64. Epub 2012 Dec 20 doi: 10.1177/0884533612470145. PMID: 23263929
Rees K, Guraewal S, Wong YL, Majanbu DL, Mavrodaris A, Stranges S, Kandala NB, Clarke A, Franco OH
Maturitas 2010 Oct;67(2):121-8. Epub 2010 Jun 17 doi: 10.1016/j.maturitas.2010.05.006. PMID: 20850029
Puckett RM, Offringa M
Cochrane Database Syst Rev 2000;(4):CD002776. doi: 10.1002/14651858.CD002776. PMID: 11034761

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