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Small cell lung cancer(SCCL)

MedGen UID:
57450
Concept ID:
C0149925
Neoplastic Process
Synonyms: Oat cell carcinoma of lung; Oat cell lung cancer; SMALL CELL CANCER OF THE LUNG, SOMATIC; Small cell lung carcinoma
Modes of inheritance:
Autosomal dominant inheritance
MedGen UID:
141047
Concept ID:
C0443147
Intellectual Product
Sources: HPO, OMIM, Orphanet
A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele.
not inherited
MedGen UID:
832438
Concept ID:
CN227390
Intellectual Product
Source: Orphanet
Describes a disorder that is not inherited.
Autosomal dominant inheritance (HPO, OMIM, Orphanet)
not inherited (Orphanet)
SNOMED CT: Small cell carcinoma of lung (254632001); SCLC - Small cell lung cancer (254632001); Small cell lung cancer (254632001); Oat cell carcinoma of lung (254633006)
 
Gene (location): RB1 (13q14.2)
OMIM®: 182280
HPO: HP:0030357
Orphanet: ORPHA70573

Definition

A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA). [from MeSH]

Clinical features

Neoplasm of lung
MedGen UID:
7400
Concept ID:
C0024121
Neoplastic Process
A benign or malignant, primary or metastatic neoplasm involving the lungs. Representative examples of benign neoplasms include adenoma, papilloma, chondroma, and endobronchial lipoma. Representative examples of malignant neoplasms include carcinoma, carcinoid tumor, sarcoma, and lymphoma.

Recent clinical studies

Etiology

Arnold BN, Thomas DC, Rosen JE, Salazar MC, Detterbeck FC, Blasberg JD, Boffa DJ, Kim AW
Surgery 2017 Sep;162(3):640-651. Epub 2017 Jul 8 doi: 10.1016/j.surg.2017.04.025. PMID: 28697883
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team.
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article
Yamanashi K, Okumura N, Yamamoto Y, Takahashi A, Nakashima T, Matsuoka T, Kameyama K
Asian Cardiovasc Thorac Ann 2017 Jun;25(5):371-377. Epub 2017 Jun 7 doi: 10.1177/0218492317714669. PMID: 28592139
Ren Y, Cao Y, Hu W, Wei X, Shen X
Int J Clin Oncol 2017 Oct;22(5):865-871. Epub 2017 May 9 doi: 10.1007/s10147-017-1131-0. PMID: 28488012Free PMC Article
Maddison P
Lung Cancer 2017 Apr;106:67-69. Epub 2017 Feb 4 doi: 10.1016/j.lungcan.2017.01.018. PMID: 28285696

Diagnosis

Sun H, Ma H, Wang J, Xia L, Zhu G, Wang Z, Sun J, Chen Z
Tumour Biol 2017 Jul;39(7):1010428317709639. doi: 10.1177/1010428317709639. PMID: 28714370
Ren Y, Cao Y, Hu W, Wei X, Shen X
Int J Clin Oncol 2017 Oct;22(5):865-871. Epub 2017 May 9 doi: 10.1007/s10147-017-1131-0. PMID: 28488012Free PMC Article
Barnes H, See K, Barnett S, Manser R
Cochrane Database Syst Rev 2017 Apr 21;4:CD011917. doi: 10.1002/14651858.CD011917.pub2. PMID: 28429473
Zhao F, Zhou Y, Ge PF, Huang CJ, Yu Y, Li J, Sun YG, Meng YC, Xu JX, Jiang T, Zhang ZX, Sun JP, Wang W
BMC Cancer 2017 Apr 13;17(1):267. doi: 10.1186/s12885-017-3273-x. PMID: 28407802Free PMC Article
Maddison P
Lung Cancer 2017 Apr;106:67-69. Epub 2017 Feb 4 doi: 10.1016/j.lungcan.2017.01.018. PMID: 28285696

Therapy

Sun H, Ma H, Wang J, Xia L, Zhu G, Wang Z, Sun J, Chen Z
Tumour Biol 2017 Jul;39(7):1010428317709639. doi: 10.1177/1010428317709639. PMID: 28714370
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team.
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article
Yamanashi K, Okumura N, Yamamoto Y, Takahashi A, Nakashima T, Matsuoka T, Kameyama K
Asian Cardiovasc Thorac Ann 2017 Jun;25(5):371-377. Epub 2017 Jun 7 doi: 10.1177/0218492317714669. PMID: 28592139
Maddison P
Lung Cancer 2017 Apr;106:67-69. Epub 2017 Feb 4 doi: 10.1016/j.lungcan.2017.01.018. PMID: 28285696
Chae YK, Pan A, Davis AA, Mohindra N, Matsangou M, Villaflor V, Giles F
Clin Lung Cancer 2017 Mar;18(2):132-140. Epub 2016 Jul 9 doi: 10.1016/j.cllc.2016.07.004. PMID: 27520630

Prognosis

Wang Y, Li N, Che S, Jin T, Piao J, Liu S, Lin Z
Tumour Biol 2017 Jul;39(7):1010428317709675. doi: 10.1177/1010428317709675. PMID: 28718367
Faivre-Finn C, Snee M, Ashcroft L, Appel W, Barlesi F, Bhatnagar A, Bezjak A, Cardenal F, Fournel P, Harden S, Le Pechoux C, McMenemin R, Mohammed N, O'Brien M, Pantarotto J, Surmont V, Van Meerbeeck JP, Woll PJ, Lorigan P, Blackhall F; CONVERT Study Team.
Lancet Oncol 2017 Aug;18(8):1116-1125. Epub 2017 Jun 20 doi: 10.1016/S1470-2045(17)30318-2. PMID: 28642008Free PMC Article
Yamanashi K, Okumura N, Yamamoto Y, Takahashi A, Nakashima T, Matsuoka T, Kameyama K
Asian Cardiovasc Thorac Ann 2017 Jun;25(5):371-377. Epub 2017 Jun 7 doi: 10.1177/0218492317714669. PMID: 28592139
Ren Y, Cao Y, Hu W, Wei X, Shen X
Int J Clin Oncol 2017 Oct;22(5):865-871. Epub 2017 May 9 doi: 10.1007/s10147-017-1131-0. PMID: 28488012Free PMC Article
Chae YK, Pan A, Davis AA, Mohindra N, Matsangou M, Villaflor V, Giles F
Clin Lung Cancer 2017 Mar;18(2):132-140. Epub 2016 Jul 9 doi: 10.1016/j.cllc.2016.07.004. PMID: 27520630

Clinical prediction guides

Wang Y, Li N, Che S, Jin T, Piao J, Liu S, Lin Z
Tumour Biol 2017 Jul;39(7):1010428317709675. doi: 10.1177/1010428317709675. PMID: 28718367
Sun H, Ma H, Wang J, Xia L, Zhu G, Wang Z, Sun J, Chen Z
Tumour Biol 2017 Jul;39(7):1010428317709639. doi: 10.1177/1010428317709639. PMID: 28714370
Yamanashi K, Okumura N, Yamamoto Y, Takahashi A, Nakashima T, Matsuoka T, Kameyama K
Asian Cardiovasc Thorac Ann 2017 Jun;25(5):371-377. Epub 2017 Jun 7 doi: 10.1177/0218492317714669. PMID: 28592139
Ren Y, Cao Y, Hu W, Wei X, Shen X
Int J Clin Oncol 2017 Oct;22(5):865-871. Epub 2017 May 9 doi: 10.1007/s10147-017-1131-0. PMID: 28488012Free PMC Article
Maddison P
Lung Cancer 2017 Apr;106:67-69. Epub 2017 Feb 4 doi: 10.1016/j.lungcan.2017.01.018. PMID: 28285696

Recent systematic reviews

Shaw AT, Kim TM, Crinò L, Gridelli C, Kiura K, Liu G, Novello S, Bearz A, Gautschi O, Mok T, Nishio M, Scagliotti G, Spigel DR, Deudon S, Zheng C, Pantano S, Urban P, Massacesi C, Viraswami-Appanna K, Felip E
Lancet Oncol 2017 Jul;18(7):874-886. Epub 2017 Jun 9 doi: 10.1016/S1470-2045(17)30339-X. PMID: 28602779
Cui S, Jiang L
Tumour Biol 2017 May;39(5):1010428317705340. doi: 10.1177/1010428317705340. PMID: 28468578
Barnes H, See K, Barnett S, Manser R
Cochrane Database Syst Rev 2017 Apr 21;4:CD011917. doi: 10.1002/14651858.CD011917.pub2. PMID: 28429473
Yu Z, Zhang G, Yang M, Zhang S, Zhao B, Shen G, Chai Y
Oncotarget 2017 Jan 17;8(3):4043-4050. doi: 10.18632/oncotarget.14022. PMID: 28008142Free PMC Article
Tong S, Fan K, Jiang K, Zhai W, Fang B, Wang SH, Wang JJ
Curr Med Res Opin 2017 Jan;33(1):31-37. Epub 2016 Sep 22 doi: 10.1080/03007995.2016.1232705. PMID: 27590399

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