Format

Send to:

Choose Destination

Links from PubMed

Pure autonomic failure

MedGen UID:
830997
Concept ID:
CN205091
Disease or Syndrome
Synonyms: Bradbury-Eggleston syndrome; Idiopathic orthostatic hypotension; PAF; Pure dysautonomia; Pure idiopatic dysautonomia
Modes of inheritance:
not inherited
MedGen UID:
832438
Concept ID:
CN227390
Intellectual Product
Source: Orphanet
Describes a disorder that is not inherited.
not inherited (Orphanet)
 
Orphanet: ORPHA441

Definition

Pure autonomic failure (PAF) is a neurodegenerative disease that affects the sympathetic branch of the autonomous nervous system and that manifests with orthostatic hypotension. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPure autonomic failure
Follow this link to review classifications for Pure autonomic failure in Orphanet.

Recent clinical studies

Etiology

Singer W, Berini SE, Sandroni P, Fealey RD, Coon EA, Suarez MD, Benarroch EE, Low PA
Neurology 2017 Mar 21;88(12):1129-1136. Epub 2017 Feb 15 doi: 10.1212/WNL.0000000000003737. PMID: 28202694Free PMC Article
Isonaka R, Holmes C, Cook GA, Sullivan P, Sharabi Y, Goldstein DS
Clin Auton Res 2017 Apr;27(2):97-101. Epub 2017 Feb 10 doi: 10.1007/s10286-017-0404-z. PMID: 28188385
Kaufmann H, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Low PA, Singer W, Goldstein DS, Peltier AC, Shibao CA, Gibbons CH, Freeman R, Robertson D; Autonomic Disorders Consortium.
Ann Neurol 2017 Feb;81(2):287-297. doi: 10.1002/ana.24877. PMID: 28093795Free PMC Article
Miglis MG, Muppidi S, During E, Jaradeh S
Clin Auton Res 2017 Feb;27(1):41-44. Epub 2016 Oct 18 doi: 10.1007/s10286-016-0386-2. PMID: 27757562
Donadio V, Incensi A, Piccinini C, Cortelli P, Giannoccaro MP, Baruzzi A, Liguori R
Ann Neurol 2016 Feb;79(2):306-16. Epub 2015 Dec 29 doi: 10.1002/ana.24567. PMID: 26606657

Diagnosis

Isonaka R, Holmes C, Cook GA, Sullivan P, Sharabi Y, Goldstein DS
Clin Auton Res 2017 Apr;27(2):97-101. Epub 2017 Feb 10 doi: 10.1007/s10286-017-0404-z. PMID: 28188385
Kaufmann H, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Low PA, Singer W, Goldstein DS, Peltier AC, Shibao CA, Gibbons CH, Freeman R, Robertson D; Autonomic Disorders Consortium.
Ann Neurol 2017 Feb;81(2):287-297. doi: 10.1002/ana.24877. PMID: 28093795Free PMC Article
Miglis MG, Muppidi S, During E, Jaradeh S
Clin Auton Res 2017 Feb;27(1):41-44. Epub 2016 Oct 18 doi: 10.1007/s10286-016-0386-2. PMID: 27757562
Thaisetthawatkul P
Curr Neurol Neurosci Rep 2016 Aug;16(8):74. doi: 10.1007/s11910-016-0673-2. PMID: 27338613
Zekeridou A, Michel P, Medlin F, Hayoz D, Lalive PH, Kuntzer T
Clin Auton Res 2015 Aug;25(4):251-3. Epub 2015 Jul 3 doi: 10.1007/s10286-015-0290-1. PMID: 26138858

Therapy

St Louis EK, Boeve AR, Boeve BF
Mov Disord 2017 May;32(5):645-658. doi: 10.1002/mds.27018. PMID: 28513079
Arnold AC, Okamoto LE, Gamboa A, Black BK, Raj SR, Elijovich F, Robertson D, Shibao CA, Biaggioni I
Hypertension 2016 Feb;67(2):424-9. Epub 2015 Dec 7 doi: 10.1161/HYPERTENSIONAHA.115.06617. PMID: 26644241Free PMC Article
Zekeridou A, Michel P, Medlin F, Hayoz D, Lalive PH, Kuntzer T
Clin Auton Res 2015 Aug;25(4):251-3. Epub 2015 Jul 3 doi: 10.1007/s10286-015-0290-1. PMID: 26138858
Goldstein DS, Holmes C, Sharabi Y
Brain 2012 Jun;135(Pt 6):1900-13. Epub 2012 Mar 26 doi: 10.1093/brain/aws055. PMID: 22451506Free PMC Article
Asahina M, Akaogi Y, Yamanaka Y, Koyama Y, Hattori T
Parkinsonism Relat Disord 2009 Jun;15(5):347-50. Epub 2008 Sep 19 doi: 10.1016/j.parkreldis.2008.08.001. PMID: 18805037

Prognosis

Isonaka R, Holmes C, Cook GA, Sullivan P, Sharabi Y, Goldstein DS
Clin Auton Res 2017 Apr;27(2):97-101. Epub 2017 Feb 10 doi: 10.1007/s10286-017-0404-z. PMID: 28188385
Kaufmann H, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Low PA, Singer W, Goldstein DS, Peltier AC, Shibao CA, Gibbons CH, Freeman R, Robertson D; Autonomic Disorders Consortium.
Ann Neurol 2017 Feb;81(2):287-297. doi: 10.1002/ana.24877. PMID: 28093795Free PMC Article
Miglis MG, Muppidi S, During E, Jaradeh S
Clin Auton Res 2017 Feb;27(1):41-44. Epub 2016 Oct 18 doi: 10.1007/s10286-016-0386-2. PMID: 27757562
Thaisetthawatkul P
Curr Neurol Neurosci Rep 2016 Aug;16(8):74. doi: 10.1007/s11910-016-0673-2. PMID: 27338613
Zekeridou A, Michel P, Medlin F, Hayoz D, Lalive PH, Kuntzer T
Clin Auton Res 2015 Aug;25(4):251-3. Epub 2015 Jul 3 doi: 10.1007/s10286-015-0290-1. PMID: 26138858

Clinical prediction guides

Singer W, Berini SE, Sandroni P, Fealey RD, Coon EA, Suarez MD, Benarroch EE, Low PA
Neurology 2017 Mar 21;88(12):1129-1136. Epub 2017 Feb 15 doi: 10.1212/WNL.0000000000003737. PMID: 28202694Free PMC Article
Kaufmann H, Norcliffe-Kaufmann L, Palma JA, Biaggioni I, Low PA, Singer W, Goldstein DS, Peltier AC, Shibao CA, Gibbons CH, Freeman R, Robertson D; Autonomic Disorders Consortium.
Ann Neurol 2017 Feb;81(2):287-297. doi: 10.1002/ana.24877. PMID: 28093795Free PMC Article
Donadio V, Cortelli P, Elam M, Di Stasi V, Montagna P, Holmberg B, Giannoccaro MP, Bugiardini E, Avoni P, Baruzzi A, Liguori R
J Neurol Neurosurg Psychiatry 2010 Dec;81(12):1327-35. Epub 2010 Jul 26 doi: 10.1136/jnnp.2009.198135. PMID: 20660924
Silveira-Moriyama L, Mathias C, Mason L, Best C, Quinn NP, Lees AJ
Neurology 2009 May 12;72(19):1677-81. doi: 10.1212/WNL.0b013e3181a55fd2. PMID: 19433741
Goldstein DS, Sewell L
Parkinsonism Relat Disord 2009 Aug;15(7):516-20. Epub 2009 Feb 7 doi: 10.1016/j.parkreldis.2008.12.009. PMID: 19201246Free PMC Article

Supplemental Content

Table of contents

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...
    Support Center