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1.

Malignant Breast Neoplasm

Breast cancer affects one in eight women during their lives. No one knows why some women get breast cancer, but there are many risk factors. Risks that you cannot change include. -Age - the risk rises as you get older. -Genes - two genes, BRCA1 and BRCA2, greatly increase the risk. Women who have family members with breast or ovarian cancer may wish to be tested for the genes. -Personal factors - beginning periods before age 12 or going through menopause after age 55. Other risks include obesity, using hormone replacement therapy (also called menopausal hormone therapy), taking birth control pills, drinking alcohol, not having children or having your first child after age 35, and having dense breasts. Symptoms of breast cancer may include a lump in the breast, a change in size or shape of the breast, and discharge from a nipple. Breast self-exams and mammography can help find breast cancer early, when it is most treatable. One possible treatment is surgery. It could be a lumpectomy or a mastectomy. Other treatments include radiation therapy, chemotherapy, hormone therapy, and targeted therapy. Targeted therapy uses substances that attack cancer cells without harming normal cells. Men can have breast cancer, too, but it is rare. NIH: National Cancer Institute.  [from MedlinePlus]

MedGen UID:
651
Concept ID:
C0006142
Neoplastic Process
2.

breast cancer

MedGen UID:
880206
Concept ID:
CN235590
Finding
3.

Tea intake

MedGen UID:
641276
Concept ID:
C0556161
Finding
4.

Neoplasm of the breast

A tumor (abnormal growth of tissue) of the breast. [from HPO]

MedGen UID:
506444
Concept ID:
CN116912
Finding
5.

Green Tea Extract

Tea derived from the dried leaves of the plant Camellia sinensis with potential antioxidant, chemopreventive, and lipid-lowering activities. Green tea contains polyphenols that are believed to be responsible for its chemopreventive effect. The polyphenol fraction contains mainly Epigallocatechin-3-gallate (EGCG) and other catechins, such as epicatechin (EC), gallocatechin gallate (GCG), epigallocatechin (EGC), and epicatechin gallate (ECG). Green tea polyphenols act as antioxidants and free radical scavengers and may affect enzymes involved in cellular replication and tumor angiogenesis by modulating angiogenic factors, such as vascular endothelial growth factor (VEGF). [from NCI]

MedGen UID:
309941
Concept ID:
C1704263
Organic Chemical; Pharmacologic Substance
6.

ins(3;3)

MedGen UID:
273723
Concept ID:
C1515658
Cell or Molecular Dysfunction
7.

Neoplasm of breast

Tumors or cancer of the human BREAST. [from MeSH]

MedGen UID:
264172
Concept ID:
C1458155
Neoplastic Process
8.

Breast carcinoma

The presence of a carcinoma of the breast. [from HPO]

MedGen UID:
146260
Concept ID:
C0678222
Neoplastic Process
9.

Folate

Class of water-soluble vitamins that are coenzymes in single-carbon transfers in the metabolism of nucleic and amino acids. (DRI) [from NCI_CRCH]

MedGen UID:
59819
Concept ID:
C0178638
Organic Chemical; Pharmacologic Substance; Vitamin
10.

Experimental Tumor

Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms. [from MeSH]

MedGen UID:
10216
Concept ID:
C0027659
Experimental Model of Disease; Neoplastic Process
11.

Folate intake

MedGen UID:
648695
Concept ID:
C0564428
Finding
12.

Polyphenol

A substance that is found in many plants and gives some flowers, fruits, and vegetables their color. Polyphenols have antioxidant activity. [from NCI_NCI-GLOSS]

MedGen UID:
34867
Concept ID:
C0071649
Organic Chemical; Pharmacologic Substance
13.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
14.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
15.

Plant Preparations

Material prepared from plants. [from MeSH]

MedGen UID:
183699
Concept ID:
C0949854
Pharmacologic Substance
16.

(+)-Cyanidanol-3

MedGen UID:
181518
Concept ID:
C0917995
Organic Chemical; Pharmacologic Substance
17.

KB-53

MedGen UID:
163890
Concept ID:
C0878496
Organic Chemical; Pharmacologic Substance
18.

Folacin

folate and its derivatives. [from CRISP]

MedGen UID:
152036
Concept ID:
C0699376
Organic Chemical; Pharmacologic Substance; Vitamin
19.

Skin and Connective Tissue Diseases

A collective term for diseases of the skin and its appendages and of connective tissue. [from MeSH]

MedGen UID:
59786
Concept ID:
C0175166
Disease or Syndrome
20.

Risk factor

Something that increases the chance of developing a disease. Some examples of risk factors for cancer are age, a family history of certain cancers, use of tobacco products, being exposed to radiation or certain chemicals, infection with certain viruses or bacteria, and certain genetic changes. [from NCI_NCI-GLOSS]

MedGen UID:
48477
Concept ID:
C0035648
Finding
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