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Hepatitis

MedGen UID:
5515
Concept ID:
C0019158
Disease or Syndrome
Synonyms: Liver inflammation
SNOMED CT: Inflammatory disorder of liver (128241005); Inflammatory disease of liver (128241005); Hepatitis (128241005); Inflammatory liver disease (128241005)
 
HPO: HP:0012115

Conditions with this feature

Halothane hepatitis
MedGen UID:
66842
Concept ID:
C0241913
Disease or Syndrome
Hepatitis b vaccine, response to
MedGen UID:
333608
Concept ID:
C1840634
Finding
More than 2 billion people have been infected with the hepatitis B virus (HBV; see 610424), and more than 350 million of these people are chronic carriers. Each year more than half a million die as a result of acute or chronic HBV infection. Vaccination has been highly successful at preventing new HBV infections and has been implemented into the national immunization programs of more than 150 countries. However, the immune response to HBV vaccination varies greatly among individuals, with 5 to 10% of healthy adults failing to produce protective levels of antibodies. Several factors have been implicated in determining the response to HBV vaccination, including physical factors, such as age, gender, obesity, immunosuppression, and smoking, as well as variation in genes of the immune system (summary by Davila et al., 2010).
Cyanosis and hepatic disease
MedGen UID:
387820
Concept ID:
C1857443
Disease or Syndrome
Complement component c1s deficiency
MedGen UID:
462428
Concept ID:
C3151078
Disease or Syndrome
Bile acid synthesis defect, congenital, 3
MedGen UID:
462497
Concept ID:
C3151147
Disease or Syndrome
Trichohepatoenteric syndrome 2
MedGen UID:
482919
Concept ID:
C3281289
Disease or Syndrome
Trichohepatoenteric syndrome (THES), generally considered to be a neonatal enteropathy, is characterized by intractable diarrhea (seen in almost all affected children), woolly hair (seen in all), intrauterine growth restriction, facial dysmorphism, and short stature. Additional findings include poorly characterized immunodeficiency, recurrent infections, skin abnormalities, and liver disease. Mild intellectual disability (ID) is seen in about 50% of affected individuals. Less common findings include congenital heart defects and platelet anomalies. To date 52 affected individuals have been reported.

Recent clinical studies

Etiology

Lightsey JM, Rockey DC
Curr Opin Gastroenterol 2017 May;33(3):158-163. doi: 10.1097/MOG.0000000000000355. PMID: 28346236
Tian T, Wang M, Zhu W, Dai ZM, Lin S, Yang PT, Liu XH, Liu K, Zhu YY, Zheng Y, Liu M, Dai ZJ
Aging (Albany NY) 2017 Jan 31;9(2):381-392. doi: 10.18632/aging.101160. PMID: 28148887Free PMC Article
Patel KR, Bertuch A, Sasa GS, Himes RW, Wu H
J Pediatr Gastroenterol Nutr 2017 Jan;64(1):e7-e12. doi: 10.1097/MPG.0000000000001271. PMID: 28030425
Albuquerque A, Rodrigues S, Macedo G
Scand J Gastroenterol 2016 Nov;51(11):1316-20. Epub 2016 Jul 7 doi: 10.1080/00365521.2016.1203017. PMID: 27387923
Wang X, Qian L, Jia L, Bellah R, Wang N, Xin Y, Liu Q
J Ultrasound Med 2016 Jul;35(7):1475-9. Epub 2016 May 26 doi: 10.7863/ultra.15.08031. PMID: 27229132

Diagnosis

Lightsey JM, Rockey DC
Curr Opin Gastroenterol 2017 May;33(3):158-163. doi: 10.1097/MOG.0000000000000355. PMID: 28346236
Adiga A, Nugent K
Am J Med Sci 2017 Apr;353(4):329-335. Epub 2016 Nov 4 doi: 10.1016/j.amjms.2016.10.014. PMID: 28317620
Weemhoff JL, Woolbright BL, Jenkins RE, McGill MR, Sharpe MR, Olson JC, Antoine DJ, Curry SC, Jaeschke H
Liver Int 2017 Mar;37(3):377-384. Epub 2016 Aug 6 doi: 10.1111/liv.13202. PMID: 27429052Free PMC Article
Albuquerque A, Rodrigues S, Macedo G
Scand J Gastroenterol 2016 Nov;51(11):1316-20. Epub 2016 Jul 7 doi: 10.1080/00365521.2016.1203017. PMID: 27387923
Wang X, Qian L, Jia L, Bellah R, Wang N, Xin Y, Liu Q
J Ultrasound Med 2016 Jul;35(7):1475-9. Epub 2016 May 26 doi: 10.7863/ultra.15.08031. PMID: 27229132

Therapy

Patel KR, Bertuch A, Sasa GS, Himes RW, Wu H
J Pediatr Gastroenterol Nutr 2017 Jan;64(1):e7-e12. doi: 10.1097/MPG.0000000000001271. PMID: 28030425
Bright-Thomas RJ, Gondker AR, Morris J, Ormerod LP
Int J Tuberc Lung Dis 2016 Dec;20(12):1621-1624. PMID: 27931337
Tagawa Y, Saito T, Takada K, Kawahata K, Kohsaka H
Lupus 2016 Apr;25(5):543-6. Epub 2016 Jan 12 doi: 10.1177/0961203315625118. PMID: 26762472
Bishara R, Braun-Moscovici Y, Dagan A, Toledano K, Saadi T, Sabo E, Balbir-Gurman A
Clin Rheumatol 2016 Mar;35(3):795-800. Epub 2014 Nov 22 doi: 10.1007/s10067-014-2829-2. PMID: 25413736
Gupta N, Njei B
J Dig Dis 2015 Nov;16(11):683-8. doi: 10.1111/1751-2980.12273. PMID: 26147671Free PMC Article

Prognosis

Lightsey JM, Rockey DC
Curr Opin Gastroenterol 2017 May;33(3):158-163. doi: 10.1097/MOG.0000000000000355. PMID: 28346236
Adiga A, Nugent K
Am J Med Sci 2017 Apr;353(4):329-335. Epub 2016 Nov 4 doi: 10.1016/j.amjms.2016.10.014. PMID: 28317620
Albuquerque A, Rodrigues S, Macedo G
Scand J Gastroenterol 2016 Nov;51(11):1316-20. Epub 2016 Jul 7 doi: 10.1080/00365521.2016.1203017. PMID: 27387923
Wang X, Qian L, Jia L, Bellah R, Wang N, Xin Y, Liu Q
J Ultrasound Med 2016 Jul;35(7):1475-9. Epub 2016 May 26 doi: 10.7863/ultra.15.08031. PMID: 27229132
Tagawa Y, Saito T, Takada K, Kawahata K, Kohsaka H
Lupus 2016 Apr;25(5):543-6. Epub 2016 Jan 12 doi: 10.1177/0961203315625118. PMID: 26762472

Clinical prediction guides

Lightsey JM, Rockey DC
Curr Opin Gastroenterol 2017 May;33(3):158-163. doi: 10.1097/MOG.0000000000000355. PMID: 28346236
Weemhoff JL, Woolbright BL, Jenkins RE, McGill MR, Sharpe MR, Olson JC, Antoine DJ, Curry SC, Jaeschke H
Liver Int 2017 Mar;37(3):377-384. Epub 2016 Aug 6 doi: 10.1111/liv.13202. PMID: 27429052Free PMC Article
Albuquerque A, Rodrigues S, Macedo G
Scand J Gastroenterol 2016 Nov;51(11):1316-20. Epub 2016 Jul 7 doi: 10.1080/00365521.2016.1203017. PMID: 27387923
Wang X, Qian L, Jia L, Bellah R, Wang N, Xin Y, Liu Q
J Ultrasound Med 2016 Jul;35(7):1475-9. Epub 2016 May 26 doi: 10.7863/ultra.15.08031. PMID: 27229132
Tagawa Y, Saito T, Takada K, Kawahata K, Kohsaka H
Lupus 2016 Apr;25(5):543-6. Epub 2016 Jan 12 doi: 10.1177/0961203315625118. PMID: 26762472

Recent systematic reviews

Tian T, Wang M, Zhu W, Dai ZM, Lin S, Yang PT, Liu XH, Liu K, Zhu YY, Zheng Y, Liu M, Dai ZJ
Aging (Albany NY) 2017 Jan 31;9(2):381-392. doi: 10.18632/aging.101160. PMID: 28148887Free PMC Article
Herrmann ES, Matusiewicz AK, Stitzer ML, Higgins ST, Sigmon SC, Heil SH
J Subst Abuse Treat 2017 Jan;72:117-125. Epub 2016 Jun 24 doi: 10.1016/j.jsat.2016.06.009. PMID: 27394070Free PMC Article
Tapper EB, Sengupta N, Bonder A
Am J Med 2015 Dec;128(12):1314-21. Epub 2015 Aug 21 doi: 10.1016/j.amjmed.2015.07.033. PMID: 26299319
Head MG, Fitchett JR, Cooke GS, Foster GR, Atun R
J Viral Hepat 2015 Mar;22(3):230-7. Epub 2014 Aug 22 doi: 10.1111/jvh.12300. PMID: 25146854Free PMC Article
Zheng R, Zhao W, Dai D, Li C
Tumour Biol 2014 Feb;35(2):1313-8. Epub 2013 Oct 24 doi: 10.1007/s13277-013-1174-4. PMID: 24155211

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