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Items: 4

1.

Efavirenz

A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication. In combination with other antiretroviral drugs, this agent has been shown to significantly reduce HIV viral load, retarding or preventing damage to the immune system and reducing the risk of developing AIDS. Efavirenz induces activity of the cytochrome P450 system, accelerating its own metabolism. [from NCI]

MedGen UID:
194090
Concept ID:
C0674428
Organic Chemical; Pharmacologic Substance
2.

Stavudine

A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV. [from MeSH]

MedGen UID:
103901
Concept ID:
C0164662
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
3.

Lamivudine

A reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease. [from MeSH]

MedGen UID:
64917
Concept ID:
C0209738
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
4.

Suppression

MedGen UID:
526147
Concept ID:
C0221103
Pathologic Function
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