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Cytoprotective agent

MedGen UID:
224782
Concept ID:
C1268903
Pharmacologic Substance
Synonyms: Cytoprotectants; Cytoprotective Agent; Cytoprotective Drugs
SNOMED CT: Cytoprotective agent (372546009); Cytoprotective agent (108819005)
 

Definition

Agents administered before, with, or after cancer therapy to reduce or prevent damage or toxicity to the normal cells. (NCI) [from NCI]

Recent clinical studies

Etiology

Joyeux-Faure M, Durand M, Bedague D, Protar D, Incagnoli P, Paris A, Ribuot C, Levy P, Chavanon O
Fundam Clin Pharmacol 2012 Dec;26(6):761-70. Epub 2011 Sep 20 doi: 10.1111/j.1472-8206.2011.00992.x. PMID: 21929528
Genvresse I, Lange C, Schanz J, Schweigert M, Harder H, Possinger K, Späth-Schwalbe E
Anticancer Drugs 2001 Apr;12(4):345-9. PMID: 11335791
Johnson PW, Muers MF, Peake MD, Poulter KM, Gurney EM, Napp VV, Hepburn PM, Brown JM
Br J Cancer 2001 Jan 5;84(1):19-24. doi: 10.1054/bjoc.2000.1539. PMID: 11139307Free PMC Article
Czejka M, Schueller J, Eder I, Reznicek G, Kraule C, Zeleni U, Freitag R
Anticancer Res 2000 Sep-Oct;20(5C):3871-7. PMID: 11268469
De Souza CA, Santini G, Marino G, Nati S, Congiu AM, Vigorito AC, Damasio E
Braz J Med Biol Res 2000 Jul;33(7):791-8. PMID: 10881054

Diagnosis

Zager RA, Johnson AC, Frostad K
Am J Physiol Renal Physiol 2016 Sep 1;311(3):F640-51. Epub 2016 May 11 doi: 10.1152/ajprenal.00264.2016. PMID: 27170684
Mo C, Sun G, Lu ML, Zhang L, Wang YZ, Sun X, Yang YS
World J Gastroenterol 2015 May 7;21(17):5382-92. doi: 10.3748/wjg.v21.i17.5382. PMID: 25954113Free PMC Article
Roubille F, Micheau A, Combes S, Thibaut S, Souteyrand G, Cayla G, Bonello L, Lesavre N, Sportouch-Dukhan C, Klein F, Berboucha S, Cade S, Cung TT, Raczka F, Macia JC, Gervasoni R, Cransac F, Leclercq F, Barrère-Lemaire S, Paganelli F, Mottref P, Vernhet Kovacsik H, Ovize M, Piot C
Arch Cardiovasc Dis 2013 Mar;106(3):135-45. Epub 2013 Feb 1 doi: 10.1016/j.acvd.2012.12.001. PMID: 23582675
Kang HJ, Kim HS
Expert Rev Cardiovasc Ther 2008 Jun;6(5):703-13. doi: 10.1586/14779072.6.5.703. PMID: 18510486
Said T, Dutot M, Martin C, Beaudeux JL, Boucher C, Enee E, Baudouin C, Warnet JM, Rat P
Eur J Pharm Sci 2007 Mar;30(3-4):203-10. Epub 2006 Nov 9 doi: 10.1016/j.ejps.2006.11.001. PMID: 17188472

Therapy

Martinel Lamas DJ, Nicoud MB, Sterle HA, Cremaschi GA, Medina VA
Cell Death Dis 2015 Dec 31;6:e2029. doi: 10.1038/cddis.2015.378. PMID: 26720338Free PMC Article
Jiang ZG, Lu XC, Nelson V, Yang X, Pan W, Chen RW, Lebowitz MS, Almassian B, Tortella FC, Brady RO, Ghanbari HA
Proc Natl Acad Sci U S A 2006 Jan 31;103(5):1581-6. Epub 2006 Jan 19 doi: 10.1073/pnas.0510573103. PMID: 16423893Free PMC Article
Cardinali DP, Furio AM, Reyes MP
Ann N Y Acad Sci 2005 Dec;1057:327-36. doi: 10.1196/annals.1356.025. PMID: 16399904
Zhong Z, Wheeler MD, Li X, Froh M, Schemmer P, Yin M, Bunzendaul H, Bradford B, Lemasters JJ
Curr Opin Clin Nutr Metab Care 2003 Mar;6(2):229-40. doi: 10.1097/01.mco.0000058609.19236.a4. PMID: 12589194
Genvresse I, Lange C, Schanz J, Schweigert M, Harder H, Possinger K, Späth-Schwalbe E
Anticancer Drugs 2001 Apr;12(4):345-9. PMID: 11335791

Prognosis

Zhang F, Yang B, Zhang K, Hou ML, Lu XC, Li YX
Chem Biol Drug Des 2017 May;89(5):681-693. Epub 2017 Jan 2 doi: 10.1111/cbdd.12889. PMID: 27762064
Périard JD, Ruell PA, Thompson MW, Caillaud C
Cell Stress Chaperones 2015 Nov;20(6):1037-42. Epub 2015 Aug 12 doi: 10.1007/s12192-015-0631-y. PMID: 26264882Free PMC Article
Roubille F, Micheau A, Combes S, Thibaut S, Souteyrand G, Cayla G, Bonello L, Lesavre N, Sportouch-Dukhan C, Klein F, Berboucha S, Cade S, Cung TT, Raczka F, Macia JC, Gervasoni R, Cransac F, Leclercq F, Barrère-Lemaire S, Paganelli F, Mottref P, Vernhet Kovacsik H, Ovize M, Piot C
Arch Cardiovasc Dis 2013 Mar;106(3):135-45. Epub 2013 Feb 1 doi: 10.1016/j.acvd.2012.12.001. PMID: 23582675
Gryglewski RJ
Pharmacol Rep 2008 Jan-Feb;60(1):3-11. PMID: 18276980
Johnson PW, Muers MF, Peake MD, Poulter KM, Gurney EM, Napp VV, Hepburn PM, Brown JM
Br J Cancer 2001 Jan 5;84(1):19-24. doi: 10.1054/bjoc.2000.1539. PMID: 11139307Free PMC Article

Clinical prediction guides

Zhang F, Yang B, Zhang K, Hou ML, Lu XC, Li YX
Chem Biol Drug Des 2017 May;89(5):681-693. Epub 2017 Jan 2 doi: 10.1111/cbdd.12889. PMID: 27762064
Sinn B, Schulze J, Schroeder G, Konschak R, Freyer D, Budach V, Tinhofer I
Radiat Res 2010 Nov;174(5):601-10. Epub 2010 Aug 18 doi: 10.1667/RR2147.1. PMID: 20718603
Genvresse I, Lange C, Schanz J, Schweigert M, Harder H, Possinger K, Späth-Schwalbe E
Anticancer Drugs 2001 Apr;12(4):345-9. PMID: 11335791
De Souza CA, Santini G, Marino G, Nati S, Congiu AM, Vigorito AC, Damasio E
Braz J Med Biol Res 2000 Jul;33(7):791-8. PMID: 10881054
Biasco G, Paganelli GM, Di Febo G, Siringo S, Barbara L
Digestion 1992;51(3):146-51. PMID: 1521715

Recent systematic reviews

Mo C, Sun G, Lu ML, Zhang L, Wang YZ, Sun X, Yang YS
World J Gastroenterol 2015 May 7;21(17):5382-92. doi: 10.3748/wjg.v21.i17.5382. PMID: 25954113Free PMC Article
Tamura H, Nakamura Y, Terron MP, Flores LJ, Manchester LC, Tan DX, Sugino N, Reiter RJ
Reprod Toxicol 2008 Apr;25(3):291-303. Epub 2008 Apr 1 doi: 10.1016/j.reprotox.2008.03.005. PMID: 18485664

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