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Oxycodone

MedGen UID:
18249
Concept ID:
C0030049
Organic Chemical; Pharmacologic Substance
Synonyms: Dihydrohydroxycodeinone; Dihydrone; Morphinan-6-one, 4,5-epoxy-14-hydroxy-3-methoxy-17-methyl-, (5alpha)-; Oxycodeinon; Oxycone
SNOMED CT: Oxycodone (414984009); Product containing oxycodone (414984009); Oxycodone (55452001); 14-Hydroxydihydrocodeinone (55452001); Dihydrohydroxycodeinone (55452001)
 

Definition

A semi-synthetic, morphine-like opioid alkaloid with analgesic activity. Oxycodone exerts its analgesic activity by binding to the mu-receptors in the central nervous system (CNS), thereby mimicking the effects of endogenous opioids. Binding of the opiate receptor stimulates the exchange of GTP for GDP on the G-protein complex and inhibits adenylate cyclase, thereby preventing cAMP production. Subsequently, the release of nociceptive neurotransmitters, such as substance P, gamma-aminobutyric acid (GABA), dopamine, acetylcholine, and noradrenaline, is inhibited. Oxycodone also inhibits the release of vasopressin, somatostatin, insulin, and glucagon. In addition, oxycodone closes N-type voltage-gated calcium channels and opens G-protein-coupled inwardly rectifying potassium channels resulting in hyperpolarization and reduction of neuronal excitability. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOxycodone

Recent clinical studies

Etiology

Haeseler G, Schaefers D, Prison N, Ahrens J, Liu X, Karch A
BMC Anesthesiol 2017 Jul 11;17(1):91. doi: 10.1186/s12871-017-0383-6. PMID: 28693439Free PMC Article
Lange B, von Zabern D, Elling C, Dubois C
Curr Med Res Opin 2017 Aug;33(8):1413-1422. Epub 2017 Jun 11 doi: 10.1080/03007995.2017.1335188. PMID: 28537506
Kokki M, Heikkinen M, Välitalo P, Hautajärvi H, Hokkanen J, Pitkänen H, Sankilampi U, Ranta VP, Kokki H
Br J Clin Pharmacol 2017 Apr;83(4):791-800. Epub 2016 Dec 5 doi: 10.1111/bcp.13164. PMID: 27780305Free PMC Article
Kopecky EA, Fleming AB, Levy-Cooperman N, O'Connor M, M Sellers E
J Clin Pharmacol 2017 Apr;57(4):500-512. Epub 2016 Nov 1 doi: 10.1002/jcph.833. PMID: 27669664Free PMC Article
Choi BM, Lee YH, An SM, Lee SH, Lee EK, Noh GJ
Br J Clin Pharmacol 2017 Feb;83(2):314-325. Epub 2016 Sep 29 doi: 10.1111/bcp.13101. PMID: 27558774Free PMC Article

Diagnosis

Chai PR, Carreiro S, Innes BJ, Chapman B, Schreiber KL, Edwards RR, Carrico AW, Boyer EW
Anesth Analg 2017 Dec;125(6):2105-2112. doi: 10.1213/ANE.0000000000002574. PMID: 29189367Free PMC Article
Kopecky EA, Vaughn B, Lagasse S, O'Connor M
Drugs Aging 2017 Aug;34(8):603-613. doi: 10.1007/s40266-017-0473-7. PMID: 28600725Free PMC Article
Serrie A, Lange B, Steup A
Curr Med Res Opin 2017 Aug;33(8):1423-1432. Epub 2017 Jun 11 doi: 10.1080/03007995.2017.1335189. PMID: 28537501
Kopecky EA, Fleming AB, Levy-Cooperman N, O'Connor M, M Sellers E
J Clin Pharmacol 2017 Apr;57(4):500-512. Epub 2016 Nov 1 doi: 10.1002/jcph.833. PMID: 27669664Free PMC Article
Zecca E, Brunelli C, Bracchi P, Biancofiore G, De Sangro C, Bortolussi R, Montanari L, Maltoni M, Moro C, Colonna U, Finco G, Roy MT, Ferrari V, Alabiso O, Rosti G, Kaasa S, Caraceni A
J Pain Symptom Manage 2016 Dec;52(6):783-794.e6. Epub 2016 Oct 11 doi: 10.1016/j.jpainsymman.2016.05.030. PMID: 27742577

Therapy

Haeseler G, Schaefers D, Prison N, Ahrens J, Liu X, Karch A
BMC Anesthesiol 2017 Jul 11;17(1):91. doi: 10.1186/s12871-017-0383-6. PMID: 28693439Free PMC Article
Lange B, von Zabern D, Elling C, Dubois C
Curr Med Res Opin 2017 Aug;33(8):1413-1422. Epub 2017 Jun 11 doi: 10.1080/03007995.2017.1335188. PMID: 28537506
Serrie A, Lange B, Steup A
Curr Med Res Opin 2017 Aug;33(8):1423-1432. Epub 2017 Jun 11 doi: 10.1080/03007995.2017.1335189. PMID: 28537501
Ruan X, Mancuso KF, Kaye AD
Anesthesiol Clin 2017 Jun;35(2):e163-e174. Epub 2017 Mar 14 doi: 10.1016/j.anclin.2017.01.022. PMID: 28526158
Samolsky Dekel BG, Donati G, Vasarri A, Croci Chiocchini AL, Gori A, Cavallari G, Di Nino G, Mercolini L, Protti M, Mandrioli R, Melotti RM, La Manna G
Pain Pract 2017 Jun;17(5):604-615. Epub 2016 Sep 2 doi: 10.1111/papr.12483. PMID: 27589376

Prognosis

Chai PR, Carreiro S, Innes BJ, Chapman B, Schreiber KL, Edwards RR, Carrico AW, Boyer EW
Anesth Analg 2017 Dec;125(6):2105-2112. doi: 10.1213/ANE.0000000000002574. PMID: 29189367Free PMC Article
Balyan R, Mecoli M, Venkatasubramanian R, Chidambaran V, Kamos N, Clay S, Moore DL, Mavi J, Glover CD, Szmuk P, Vinks A, Sadhasivam S
Pharmacogenomics 2017 Mar;18(4):337-348. Epub 2017 Feb 17 doi: 10.2217/pgs-2016-0183. PMID: 28244808Free PMC Article
Samolsky Dekel BG, Donati G, Vasarri A, Croci Chiocchini AL, Gori A, Cavallari G, Di Nino G, Mercolini L, Protti M, Mandrioli R, Melotti RM, La Manna G
Pain Pract 2017 Jun;17(5):604-615. Epub 2016 Sep 2 doi: 10.1111/papr.12483. PMID: 27589376
Zecca E, Brunelli C, Bracchi P, Biancofiore G, De Sangro C, Bortolussi R, Montanari L, Maltoni M, Moro C, Colonna U, Finco G, Roy MT, Ferrari V, Alabiso O, Rosti G, Kaasa S, Caraceni A
J Pain Symptom Manage 2016 Dec;52(6):783-794.e6. Epub 2016 Oct 11 doi: 10.1016/j.jpainsymman.2016.05.030. PMID: 27742577
Pergolizzi JV Jr, Seow-Choen F, Wexner SD, Zampogna G, Raffa RB, Taylor R Jr
Pain Pract 2016 Sep;16(7):924-34. Epub 2015 Sep 22 doi: 10.1111/papr.12345. PMID: 26393529

Clinical prediction guides

Haeseler G, Schaefers D, Prison N, Ahrens J, Liu X, Karch A
BMC Anesthesiol 2017 Jul 11;17(1):91. doi: 10.1186/s12871-017-0383-6. PMID: 28693439Free PMC Article
Lange B, von Zabern D, Elling C, Dubois C
Curr Med Res Opin 2017 Aug;33(8):1413-1422. Epub 2017 Jun 11 doi: 10.1080/03007995.2017.1335188. PMID: 28537506
Serrie A, Lange B, Steup A
Curr Med Res Opin 2017 Aug;33(8):1423-1432. Epub 2017 Jun 11 doi: 10.1080/03007995.2017.1335189. PMID: 28537501
Kopecky EA, Fleming AB, Levy-Cooperman N, O'Connor M, M Sellers E
J Clin Pharmacol 2017 Apr;57(4):500-512. Epub 2016 Nov 1 doi: 10.1002/jcph.833. PMID: 27669664Free PMC Article
Samolsky Dekel BG, Donati G, Vasarri A, Croci Chiocchini AL, Gori A, Cavallari G, Di Nino G, Mercolini L, Protti M, Mandrioli R, Melotti RM, La Manna G
Pain Pract 2017 Jun;17(5):604-615. Epub 2016 Sep 2 doi: 10.1111/papr.12483. PMID: 27589376

Recent systematic reviews

Schmidt-Hansen M, Bennett MI, Arnold S, Bromham N, Hilgart JS
Cochrane Database Syst Rev 2017 Aug 22;8:CD003870. doi: 10.1002/14651858.CD003870.pub6. PMID: 28829910
Lange B, von Zabern D, Elling C, Dubois C
Curr Med Res Opin 2017 Aug;33(8):1413-1422. Epub 2017 Jun 11 doi: 10.1080/03007995.2017.1335188. PMID: 28537506
Gaskell H, Derry S, Stannard C, Moore RA
Cochrane Database Syst Rev 2016 Jul 28;7:CD010692. doi: 10.1002/14651858.CD010692.pub3. PMID: 27465317
Franke RM, Morton T, Devarakonda K
Drug Des Devel Ther 2015;9:4587-97. Epub 2015 Aug 11 doi: 10.2147/DDDT.S79499. PMID: 26316698Free PMC Article
Thakur D, Dickerson S, Kumar Bhutani M, Junor R
Clin Ther 2015 Jan 1;37(1):212-24. doi: 10.1016/j.clinthera.2014.12.001. PMID: 25592091

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