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Items: 1 to 20 of 26

1.

Mesothelioma

A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed) [from MeSH]

MedGen UID:
9975
Concept ID:
C0025500
Neoplastic Process
2.

Epithelioma, malignant

MedGen UID:
639977
Concept ID:
C0553707
Neoplastic Process
3.

Malignant mesothelioma

Malignant mesothelioma is a form of cancer that originates from the cells of the mesothelium, a thin tissue layer surrounding the body's internal organs. Malignant mesothelioma is almost exclusively caused by asbestos exposure, pleural mesothelioma beeing the most common form, affecting the lining of the lungs called the pleura. Other forms such as perioneal-, percardial- or testicular- mesothelioma are much rarer. [from HPO]

MedGen UID:
506442
Concept ID:
CN116900
Finding
4.

Mesothelioma, malignant

Malignant mesothelioma is an aggressive neoplasm of the serosal lining of the chest etiologically linked to asbestos. It is diagnosed in approximately 2,000 to 3,000 individuals annually in the United States, most of whom die within 2 years of diagnosis (summary by Bott et al., 2011). See also 614327 for a tumor predisposition syndrome that may contribute to the development of malignant mesothelioma upon asbestos exposure and is caused by germline mutation in the BAP1 gene (603089) on chromosome 3p21. [from GTR]

MedGen UID:
91062
Concept ID:
C0345967
Neoplastic Process
5.

Gemcitabine

A broad-spectrum antimetabolite and deoxycytidine analogue with antineoplastic activity. Upon administration, gemcitabine is converted into the active metabolites difluorodeoxycytidine diphosphate (dFdCDP) and difluorodeoxycytidine triphosphate (dFdCTP) by deoxycytidine kinase. dFdCTP competes with deoxycytidine triphosphate (dCTP) and is incorporated into DNA. This locks DNA polymerase thereby resulting in "masked termination" during DNA replication. On the other hand, dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis. The reduction in the intracellular concentration of dCTP potentiates the incorporation of dFdCTP into DNA. [from NCI]

MedGen UID:
12514
Concept ID:
C0045093
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
6.

Independent

MedGen UID:
721426
Concept ID:
C1299583
Finding
7.

mTOR Inhibitor

Any substance that inhibits mammalian target of rapamycin (mTOR or FK506 binding protein 12-rapamycin associated protein 1 (FRAP1)), a serine/threonine protein kinase that is active in the control of cell growth, cell proliferation, and cell motility. Inhibition of mTOR can inhibit cell proliferation. [from NCI]

MedGen UID:
411559
Concept ID:
C2746052
Pharmacologic Substance
8.

Staining

MedGen UID:
352872
Concept ID:
C1704680
Finding
9.

Confirmation

Having been established or verified. [from NCI]

MedGen UID:
148194
Concept ID:
C0750484
Finding
10.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
11.

Mesothelial Neoplasm

A benign or malignant neoplasm arising from mesothelial cells. Mesothelial cells are the lining cells of the pleura and peritoneum. -- 2003 [from NCI]

MedGen UID:
811450
Concept ID:
C3714739
Neoplastic Process
12.

I-2190A

MedGen UID:
385423
Concept ID:
C2350768
Organic Chemical; Pharmacologic Substance
13.

Epithelial Neoplasm

A benign or malignant neoplasm that arises from and is composed of epithelial cells. This category include adenomas, papillomas, and carcinomas. [from NCI]

MedGen UID:
277963
Concept ID:
C1368683
Neoplastic Process
14.

Macrolide

A group of often glycosylated macrocyclic compounds formed by chain extension of multiple PROPIONATES cyclized into a large (typically 12, 14, or 16)-membered lactone. Macrolides belong to the POLYKETIDES class of natural products, and many members exhibit ANTIBIOTIC properties. [from MeSH]

MedGen UID:
129193
Concept ID:
C0282563
Organic Chemical; Pharmacologic Substance
15.

Salivary Gland Monomorphic Adenoma

A benign epithelial neoplasm arising from the salivary glands. It is characterized by the presence of a monomorphic cellular infiltrate. [from NCI]

MedGen UID:
64421
Concept ID:
C0205649
Neoplastic Process
16.

Microcystic Adenoma

A benign epithelial neoplasm characterized by a microcystic pattern. The cystic spaces are lined by small cuboidal cells without evidence of significant cytologic atypia. [from NCI]

MedGen UID:
64420
Concept ID:
C0205648
Neoplastic Process
17.

Follicular adenoma

MedGen UID:
61429
Concept ID:
C0205647
Neoplastic Process
18.

Trabecular Adenoma

A benign epithelial neoplasm characterized by the presence of a trabecular glandular architectural pattern. [from NCI]

MedGen UID:
60000
Concept ID:
C0205651
Neoplastic Process
19.

Papillary Adenoma

An adenoma characterized by the presence of papillary epithelial patterns. [from NCI]

MedGen UID:
59999
Concept ID:
C0205650
Neoplastic Process
20.

Sirolimus

A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties. [from MeSH]

MedGen UID:
35141
Concept ID:
C0072980
Antibiotic; Organic Chemical
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