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Items: 20

1.

Fluorouracil

A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid. [from MeSH]

MedGen UID:
5229
Concept ID:
C0016360
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
2.

Fluorouracil response

5-fluorouracil is a chemotherapeutic agent, and a member of the fluoropyrimidine group of substances. It is mainly used to treat solid tumors, such as colorectal, breast and aerodigestive cancers. Dihydropyrimidine dehydrogenase (DPD, encoded by the DPYD gene) is the rate-limiting enzyme for fluoropyrimidine metabolism and is therefore responsible for the detoxification of these types of drugs. Patients who are homozygous for variants in DPYD that lead to a non-functional protein, such as *2A or *13, have a high risk of severe or fatal drug toxicities and may benefit from receiving an alternative chemotherapeutic drug. Patients heterozygous for these variants also have an increased risk for drug toxicities, and reduced dosing is recommended for these individuals. Guidelines regarding the use of pharmacogenomic tests in dosing for 5-fluorouracil have been published in Clinical Pharmacology and Therapeutics by the Clinical Pharmacogenetics Implementation Consortium (CPIC) and are available on the PharmGKB website (http://www.pharmgkb.org/drug/PA128406956). [from GTR]

MedGen UID:
450455
Concept ID:
CN077983
Sign or Symptom
3.

5-[18F]Fluorouracil

The fluorine-18 (18F)-radiolabeled pyrimidine analog 5-fluorouracil (5-FU) with positron-emitting activity. Upon administration, 5-[18F]fluorouracil distribution in tumor tissue may be measured with positron emission tomography (PET). The degree of 5-[18F]fluorouracil uptake in tumor tissue may help to predict the response to 5-fluorouracil-based chemotherapy or to determine the response to other therapeutic agents used to treat 5-FU-sensitive tumors. [from NCI]

MedGen UID:
398465
Concept ID:
C2700356
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
4.

Allergy

A pathological process initiated by exposure to a defined stimulus at a dose tolerated by normal persons. It may be the manifestation of a disposition to hypersensitivity. [from SNOMEDCT_US]

MedGen UID:
9370
Concept ID:
C0020517
Pathologic Function
5.

Mutant

An altered form of an individual, organism, population, or genetic character that differs from the corresponding wild type due to one or more alterations (mutations). [from NCI]

MedGen UID:
109303
Concept ID:
C0596988
Cell or Molecular Dysfunction
6.

Examined for

Having been subjected to inspection or evaluation. [from NCI]

MedGen UID:
83047
Concept ID:
C0332128
Finding
7.

Onkofluor

MedGen UID:
297394
Concept ID:
C1564851
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
8.

Neofluor

MedGen UID:
289931
Concept ID:
C1564850
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
9.

Haemato-FU

MedGen UID:
289930
Concept ID:
C1564849
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
10.

5-Fluorouracil-Biosyn

MedGen UID:
289928
Concept ID:
C1564842
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
11.

Fluorouracil-GRY

MedGen UID:
289059
Concept ID:
C1564846
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
12.

Ribofluor

MedGen UID:
274518
Concept ID:
C1517232
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
13.

Fluracedyl

MedGen UID:
274517
Concept ID:
C1517230
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
14.

Carac

MedGen UID:
215257
Concept ID:
C0939777
Organic Chemical; Pharmacologic Substance
15.

Fluoroplex

MedGen UID:
195881
Concept ID:
C0699375
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
16.

Efudex

MedGen UID:
195880
Concept ID:
C0699372
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
17.

Adrucil

MedGen UID:
152035
Concept ID:
C0699374
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
18.

Uracil

One of four nucleotide bases in the nucleic acid RNA. [from MeSH]

MedGen UID:
22564
Concept ID:
C0041917
Biologically Active Substance; Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
19.

Immunosuppressant allergy

MedGen UID:
654491
Concept ID:
C0570719
Disease or Syndrome
20.

Antimetabolite allergy

MedGen UID:
654463
Concept ID:
C0570691
Disease or Syndrome
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