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Items: 5

1.

Pyelonephritis

An inflammation of the kidney involving the parenchyma of kidney, the renal pelvis (FMA:15575) and the kidney calices. [from HPO]

MedGen UID:
19590
Concept ID:
C0034186
Disease or Syndrome
2.

Vesicoureteral reflux

MedGen UID:
332010
Concept ID:
C1835578
Finding
3.

Reflux

The term used when liquid backs up into the esophagus from the stomach. [from NCI]

MedGen UID:
66675
Concept ID:
C0232483
Pathologic Function
4.

Vesicoureteral reflux 1

Vesicoureteral reflux (VUR) is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys. It is a risk factor for urinary tract infections. Primary VUR results from a developmental defect of the ureterovesical junction (UVJ). In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy (RN). Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, and renal insufficiency (summary by Lu et al., 2007). Genetic Heterogeneity of Vesicoureteral Reflux A locus designated VUR1 maps to chromosome 1p13. VUR2 (610878) is caused by mutation in the ROBO2 gene (602431) on chromosome 3p12.3; VUR3 (613674) is caused by mutation in the SOX17 gene (610928) on chromosome 8q11.23; VUR4 (614317) maps to chromosome 5; VUR5 (614318) maps to chromosome 13; VUR6 (614319) maps to chromosome 18; VUR7 (615390) maps to chromosome 12; and VUR8 (615963) is caused by mutation in the TNXB gene (600985) on chromosome 6p21. A possible X-linked form has been reported (VURX; 314550). [from OMIM]

MedGen UID:
21852
Concept ID:
C0042580
Disease or Syndrome
5.

Anti-Infective Agents, Urinary

Substances capable of killing agents causing urinary tract infections or of preventing them from spreading. [from MeSH]

MedGen UID:
1964
Concept ID:
C0003207
Pharmacologic Substance
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