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Items: 11

1.

Process

MedGen UID:
923307
Concept ID:
C1951340
Pharmacologic Substance
2.

Absence

MedGen UID:
739164
Concept ID:
C1689985
Anatomical Abnormality
3.

Peripheral

On or near an edge or constituting an outer boundary; the outer area. [from NCI]

MedGen UID:
59959
Concept ID:
C0205100
Spatial Concept
4.

Anemia

A laboratory test result demonstrating decreased levels of hemoglobin in a biological specimen. [from NCI]

MedGen UID:
56401
Concept ID:
C0162119
Finding
5.

Phenol

An antiseptic and disinfectant aromatic alcohol. [from MeSH]

MedGen UID:
74524
Concept ID:
C0070570
Organic Chemical; Pharmacologic Substance
6.

Phenol and derivatives

Benzene derivatives that include one or more hydroxyl groups attached to the ring structure. [from MeSH]

MedGen UID:
45854
Concept ID:
C0031428
Organic Chemical; Pharmacologic Substance
7.

Nitrile

An organic compound that contains a cyano moiety (-CN) as a functional group. [from NCI]

MedGen UID:
45099
Concept ID:
C0028131
Organic Chemical; Pharmacologic Substance
8.

Sulfone

Any of substance containing a sulfonyl functional group attached to two carbon atoms with antibiotic activity. Tthe general structural formula is R-S(=O)(=O)-R'. [from NCI]

MedGen UID:
21395
Concept ID:
C0038761
Organic Chemical; Pharmacologic Substance
9.

Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone

A proton ionophore that is commonly used as an uncoupling agent in biochemical studies. [from MeSH]

MedGen UID:
2864
Concept ID:
C0007044
Organic Chemical; Pharmacologic Substance
10.

Proton Ionophores

Chemical agents that increase the permeability of CELL MEMBRANES to PROTONS. [from MeSH]

MedGen UID:
465545
Concept ID:
C3179077
Pharmacologic Substance
11.

BH3 Mimetic ABT-737

An orally bioavailable, selective small molecule B-cell lymphoma 2 (Bcl-2) Homology 3 (BH3) mimetic, with potential pro-apoptotic and antineoplastic activities. ABT-737 binds to the hydrophobic groove of multiple members of the anti-apoptotic Bcl-2 protein family, including Bcl-2, Bcl-xl and Bcl-w. This inhibits the activity of these pro-survival proteins and restores apoptotic processes in tumor cells, via activation of Bak/Bax-mediated apoptosis. The pro-survival Bcl-2 proteins are overexpressed in many cancers and play important roles in the regulation of apoptosis. Their expression is associated with increased drug resistance and tumor cell survival. ABT-737 does not inhibit the pro-survival proteins Mcl-1, Bcl-B, Bfl-1 (A1); therefore, tumors that overexpress these Bcl-2 family proteins are resistant to ABT-737. [from NCI]

MedGen UID:
295329
Concept ID:
C1570187
Organic Chemical; Pharmacologic Substance
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