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Retinaldehyde

MedGen UID:
19764
Concept ID:
C0035331
Organic Chemical; Pharmacologic Substance; Vitamin
Synonyms: Aldehyde, Vitamin A; Axerophthal; Retinal; Retinene; Vitamin A Aldehyde
SNOMED CT: Retinaldehyde (103067001)
 

Definition

A carotenoid constituent of visual pigments. It is the oxidized form of retinol which functions as the active component of the visual cycle. It is bound to the protein opsin forming the complex rhodopsin. When stimulated by visible light, the retinal component of the rhodopsin complex undergoes isomerization at the 11-position of the double bond to the cis-form; this is reversed in "dark" reactions to return to the native trans-configuration. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetinaldehyde

Recent clinical studies

Etiology

Crocco EI, Veasey JV, Boin MF, Lellis RF, Alves RO
Cutis 2015 Nov;96(5):337-42. PMID: 26682557
Giménez-Dejoz J, Kolář MH, Ruiz FX, Crespo I, Cousido-Siah A, Podjarny A, Barski OA, Fanfrlík J, Parés X, Farrés J, Porté S
PLoS One 2015;10(7):e0134506. Epub 2015 Jul 29 doi: 10.1371/journal.pone.0134506. PMID: 26222439Free PMC Article
Singh S, Arcaroli J, Thompson DC, Messersmith W, Vasiliou V
Adv Exp Med Biol 2015;815:281-94. doi: 10.1007/978-3-319-09614-8_16. PMID: 25427913Free PMC Article
Nikolic DS, Ziori C, Kostaki M, Fontao L, Saurat JH, Kaya G
Dermatology 2014;229(2):110-5. Epub 2014 Aug 14 doi: 10.1159/000362594. PMID: 25138066
Ruiz FX, Moro A, Gallego O, Ardèvol A, Rovira C, Petrash JM, Parés X, Farrés J
Chem Biol Interact 2011 May 30;191(1-3):199-205. Epub 2011 Feb 15 doi: 10.1016/j.cbi.2011.02.007. PMID: 21329680Free PMC Article

Diagnosis

Questel E, Durbise E, Bardy AL, Schmitt AM, Josse G
Skin Res Technol 2015 May;21(2):241-6. Epub 2014 Jul 31 doi: 10.1111/srt.12182. PMID: 25078981
Masini F, Ricci F, Fossati B, Frascione P, Capizzi R, De Waure C, Guerriero C
Eur Rev Med Pharmacol Sci 2014 Aug;18(16):2283-6. PMID: 25219827
Nikolic DS, Ziori C, Kostaki M, Fontao L, Saurat JH, Kaya G
Dermatology 2014;229(2):110-5. Epub 2014 Aug 14 doi: 10.1159/000362594. PMID: 25138066
Adams MK, Belyaeva OV, Wu L, Kedishvili NY
J Biol Chem 2014 May 23;289(21):14868-80. Epub 2014 Apr 14 doi: 10.1074/jbc.M114.552257. PMID: 24733397Free PMC Article
Ziouzenkova O, Orasanu G, Sharlach M, Akiyama TE, Berger JP, Viereck J, Hamilton JA, Tang G, Dolnikowski GG, Vogel S, Duester G, Plutzky J
Nat Med 2007 Jun;13(6):695-702. Epub 2007 May 27 doi: 10.1038/nm1587. PMID: 17529981Free PMC Article

Therapy

Crocco EI, Veasey JV, Boin MF, Lellis RF, Alves RO
Cutis 2015 Nov;96(5):337-42. PMID: 26682557
Questel E, Durbise E, Bardy AL, Schmitt AM, Josse G
Skin Res Technol 2015 May;21(2):241-6. Epub 2014 Jul 31 doi: 10.1111/srt.12182. PMID: 25078981
Masini F, Ricci F, Fossati B, Frascione P, Capizzi R, De Waure C, Guerriero C
Eur Rev Med Pharmacol Sci 2014 Aug;18(16):2283-6. PMID: 25219827
Nikolic DS, Ziori C, Kostaki M, Fontao L, Saurat JH, Kaya G
Dermatology 2014;229(2):110-5. Epub 2014 Aug 14 doi: 10.1159/000362594. PMID: 25138066
Cordero A, Leon-Dorantes G, Pons-Guiraud A, Di Pietro A, Asensi SV, Walkiewicz-Cyraska B, Litvik R, Turlier V, Mery S, Merial-Kieny C
J Cosmet Dermatol 2011 Jun;10(2):110-7. doi: 10.1111/j.1473-2165.2011.00552.x. PMID: 21649816

Prognosis

Singh S, Arcaroli J, Thompson DC, Messersmith W, Vasiliou V
Adv Exp Med Biol 2015;815:281-94. doi: 10.1007/978-3-319-09614-8_16. PMID: 25427913Free PMC Article
Jackson BC, Reigan P, Miller B, Thompson DC, Vasiliou V
Pharm Res 2015 May;32(5):1648-62. Epub 2014 Nov 21 doi: 10.1007/s11095-014-1564-3. PMID: 25413692Free PMC Article
Nikolic DS, Ziori C, Kostaki M, Fontao L, Saurat JH, Kaya G
Dermatology 2014;229(2):110-5. Epub 2014 Aug 14 doi: 10.1159/000362594. PMID: 25138066
Poli F, Ribet V, Lauze C, Adhoute H, Morinet P
Dermatology 2005;210 Suppl 1:14-21. doi: 10.1159/000081498. PMID: 15724103
Mordon S, Lagarde JM, Vienne MP, Nocera T, Verriere F, Dahan S
J Cosmet Laser Ther 2004 May;6(1):5-9. doi: 10.1080/14764170310016388. PMID: 15370406

Clinical prediction guides

Crocco EI, Veasey JV, Boin MF, Lellis RF, Alves RO
Cutis 2015 Nov;96(5):337-42. PMID: 26682557
Jackson BC, Reigan P, Miller B, Thompson DC, Vasiliou V
Pharm Res 2015 May;32(5):1648-62. Epub 2014 Nov 21 doi: 10.1007/s11095-014-1564-3. PMID: 25413692Free PMC Article
Questel E, Durbise E, Bardy AL, Schmitt AM, Josse G
Skin Res Technol 2015 May;21(2):241-6. Epub 2014 Jul 31 doi: 10.1111/srt.12182. PMID: 25078981
Nikolic DS, Ziori C, Kostaki M, Fontao L, Saurat JH, Kaya G
Dermatology 2014;229(2):110-5. Epub 2014 Aug 14 doi: 10.1159/000362594. PMID: 25138066
Ruiz FX, Porté S, Gallego O, Moro A, Ardèvol A, Del Río-Espínola A, Rovira C, Farrés J, Parés X
Biochem J 2011 Dec 15;440(3):335-44. doi: 10.1042/BJ20111286. PMID: 21851338

Recent systematic reviews

Dall'oglio F, Tedeschi A, Fabbrocini G, Veraldi S, Picardo M, Micali G
G Ital Dermatol Venereol 2015 Feb;150(1):1-11. Epub 2014 Oct 15 PMID: 25315288
Valente A, Jamurtas AZ, Koutedakis Y, Flouris AD
Biol Rev Camb Philos Soc 2015 Feb;90(1):77-88. Epub 2014 Apr 7 doi: 10.1111/brv.12099. PMID: 24708171
Thielitz A, Abdel-Naser MB, Fluhr JW, Zouboulis CC, Gollnick H
J Dtsch Dermatol Ges 2008 Dec;6(12):1023-31. Epub 2008 May 13 doi: 10.1111/j.1610-0387.2008.06741.x. PMID: 18479477

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