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Items: 2

1.

Tamoxifen

An antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. [from NCI]

MedGen UID:
52642
Concept ID:
C0039286
Organic Chemical; Pharmacologic Substance
2.

Gynecomastia

Abnormal development of large mammary glands in males resulting in breast enlargement. [from HPO]

MedGen UID:
6694
Concept ID:
C0018418
Disease or Syndrome

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