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Items: 1 to 20 of 63

1.

Dopamine

A monoamine compound with positive inotropic activity. Dopamine is a naturally occurring catecholamine formed by decarboxylation of dehydroxyphenylalanine and a precursor of norepinephrine and epinephrine. Dopamine binds to alpha-1 and beta-1 adrenergic receptors. Mediated through myocardial beta-1 adrenergic receptors, dopamine increase heart rate and force, thereby increasing cardiac output. Alpha-1 adrenergic receptor stimulation on vascular smooth muscle, leads to vasoconstriction and results in an increase in systemic vascular resistance. Stimulation of dopaminergic receptors in renal vasculature, leads to renal blood vessel dilation, and an increase in glomerular filtration rate, renal blood flow, sodium excretion, and urine output. [from NCI]

MedGen UID:
41644
Concept ID:
C0013030
Biologically Active Substance; Neuroreactive Substance or Biogenic Amine; Organic Chemical; Pharmacologic Substance
2.

Seizures

Seizures are symptoms of a brain problem. They happen because of sudden, abnormal electrical activity in the brain. When people think of seizures, they often think of convulsions in which a person's body shakes rapidly and uncontrollably. Not all seizures cause convulsions. There are many types of seizures and some have mild symptoms. Seizures fall into two main groups. Focal seizures, also called partial seizures, happen in just one part of the brain. Generalized seizures are a result of abnormal activity on both sides of the brain. . Most seizures last from 30 seconds to 2 minutes and do not cause lasting harm. However, it is a medical emergency if seizures last longer than 5 minutes or if a person has many seizures and does not wake up between them. Seizures can have many causes, including medicines, high fevers, head injuries and certain diseases. People who have recurring seizures due to a brain disorder have epilepsy. . NIH: National Institute of Neurological Disorders and Stroke.  [from MedlinePlus]

MedGen UID:
20693
Concept ID:
C0036572
Sign or Symptom
3.

Disulfiram

A carbamoyl derivate used in the treatment of alcoholism. Disulfiram irreversibly inhibits acetaldehyde dehydrogenase that oxidizes the ethanol metabolite acetaldehyde into acetic acid. This leads to an accumulation of acetaldehyde that produces a variety of very unpleasant symptoms referred to as the disulfiram-alcohol reaction. This reaction includes , but is not limited to, flushing, headache, respiratory difficulty, nausea,vomiting, sweating, thirst, chest pain, tachycardia, blurred vision and hypotension. [from NCI]

MedGen UID:
8446
Concept ID:
C0012772
Organic Chemical; Pharmacologic Substance
4.

Seizures

MedGen UID:
851405
Concept ID:
CN232558
Disease or Syndrome
5.

Seizure Disorders

Epilepsy is a brain disorder that causes people to have recurring seizures. The seizures happen when clusters of nerve cells, or neurons, in the brain send out the wrong signals. People may have strange sensations and emotions or behave strangely. They may have violent muscle spasms or lose consciousness. Epilepsy has many possible causes, including illness, brain injury, and abnormal brain development. In many cases, the cause is unknown. Doctors use brain scans and other tests to diagnose epilepsy. It is important to start treatment right away. There is no cure for epilepsy, but medicines can control seizures for most people. When medicines are not working well, surgery or implanted devices such as vagus nerve stimulators may help. Special diets can help some children with epilepsy. NIH: National Institute of Neurological Disorders and Stroke.  [from MedlinePlus]

MedGen UID:
4506
Concept ID:
C0014544
Disease or Syndrome
6.

nepicastat

MedGen UID:
193487
Concept ID:
C0668779
Organic Chemical; Pharmacologic Substance
7.

Cocaine Dependence

A psychologically and socially impaired state, with or without physiological changes, that develops as a result of using cocaine and which leads to compulsive behaviors to acquire the substance. [from NCI]

MedGen UID:
154705
Concept ID:
C0600427
Mental or Behavioral Dysfunction
8.

Frequency

MedGen UID:
91210
Concept ID:
C0376249
Temporal Concept
9.

Norepinephrine

A naturally occurring catecholamine hormone that functions as a neurotransmitter in the sympathetic nervous system. Norepinephrine directly stimulates adrenergic receptors. Stimulation of alpha-adrenergic receptors causes vasoconstriction of the radial smooth muscle of the iris, arteries, arterioles, veins, urinary bladder, and the sphincter of the gastrointestinal tract. Stimulation of beta-1 adrenergic receptors causes an increase in myocardial contractility, heart rate, automaticity, and atrioventricular (AV) conduction while stimulation of beta-2 adrenergic receptors causes bronchiolar and vascular smooth muscle dilatation. [from NCI]

MedGen UID:
45125
Concept ID:
C0028351
Hormone; Neuroreactive Substance or Biogenic Amine; Organic Chemical; Pharmacologic Substance
10.

Independent

MedGen UID:
721426
Concept ID:
C1299583
Finding
11.

Dependence

The psychological or physiological need to take a substance in oder to experience its effects or to avoid the effects of its absence. [from NCI]

MedGen UID:
141006
Concept ID:
C0439857
Mental or Behavioral Dysfunction
12.

Examined for

Having been subjected to inspection or evaluation. [from NCI]

MedGen UID:
83047
Concept ID:
C0332128
Finding
13.

Inhibition

MedGen UID:
5809
Concept ID:
C0021469
Molecular Function
14.

Convulsions

MedGen UID:
885903
Concept ID:
C4048158
Sign or Symptom
15.

Antabus

MedGen UID:
292247
Concept ID:
C1569453
Organic Chemical; Pharmacologic Substance
16.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
17.

Focal seizures

Seizures of which initial semiology indicates, or is consistent with, initial activation of only part of one cerebral hemisphere. [from HPO]

MedGen UID:
199670
Concept ID:
C0751495
Sign or Symptom
18.

Dicupral

MedGen UID:
195841
Concept ID:
C0699198
Organic Chemical; Pharmacologic Substance
19.

Alcophobin

MedGen UID:
195840
Concept ID:
C0699196
Organic Chemical; Pharmacologic Substance
20.

Imuthiol

MedGen UID:
163848
Concept ID:
C0878291
Organic Chemical; Pharmacologic Substance
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