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Antidepressant

MedGen UID:
1588
Concept ID:
C0003289
Pharmacologic Substance
Synonyms: Agents, Antidepressive; Antidepressant Drugs; Antidepressants; Antidepressive Agents; Drugs, Antidepressant
SNOMED CT: Antidepressant (372720008); Antidepressant (36236003)
 

Definition

A pharmacological agent that acts on neurotransmitter signaling pathways to alleviate the symptoms of depression. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAntidepressant

Recent clinical studies

Etiology

Bushnell GA, Stürmer T, Gaynes BN, Pate V, Miller M
JAMA Psychiatry 2017 Jul 1;74(7):747-755. doi: 10.1001/jamapsychiatry.2017.1273. PMID: 28593281
García-González J, Tansey KE, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Žagar T, Czerski PM, Jerman B, Buttenschøn HN, Schulze TG, Zobel A, Farmer A, Aitchison KJ, Craig I, McGuffin P, Giupponi M, Perroud N, Bondolfi G, Evans D, O'Donovan M, Peters TJ, Wendland JR, Lewis G, Kapur S, Perlis R, Arolt V, Domschke K; Major Depressive Disorder Working Group of the Psychiatric Genomic Consortium., Breen G, Curtis C, Sang-Hyuk L, Kan C, Newhouse S, Patel H, Baune BT, Uher R, Lewis CM, Fabbri C
Prog Neuropsychopharmacol Biol Psychiatry 2017 Apr 3;75:128-134. Epub 2017 Jan 31 doi: 10.1016/j.pnpbp.2017.01.011. PMID: 28159590
Strasburger SE, Bhimani PM, Kaabe JH, Krysiak JT, Nanchanatt DL, Nguyen TN, Pough KA, Prince TA, Ramsey NS, Savsani KH, Scandlen L, Cavaretta MJ, Raffa RB
J Clin Pharm Ther 2017 Apr;42(2):147-154. Epub 2017 Jan 22 doi: 10.1111/jcpt.12497. PMID: 28111761
Braunstein D, Hardy A, Boucherie Q, Frauger E, Blin O, Gentile G, Micallef J
Fundam Clin Pharmacol 2017 Apr;31(2):226-236. Epub 2017 Jan 10 doi: 10.1111/fcp.12252. PMID: 27862243
Nielsen MB, Madsen IE, Aust B, Burr H, Rugulies R
J Affect Disord 2016 May 15;196:248-51. Epub 2016 Feb 17 doi: 10.1016/j.jad.2016.02.038. PMID: 26943941

Diagnosis

Bushnell GA, Stürmer T, Gaynes BN, Pate V, Miller M
JAMA Psychiatry 2017 Jul 1;74(7):747-755. doi: 10.1001/jamapsychiatry.2017.1273. PMID: 28593281
Amsterdam JD, Lorenzo-Luaces L, DeRubeis RJ
Bipolar Disord 2016 Nov;18(7):563-570. Epub 2016 Nov 2 doi: 10.1111/bdi.12442. PMID: 27805299Free PMC Article
Fond G, Godin O, Brunel L, Aouizerate B, Berna F, Bulzacka E, Capdevielle D, Chereau I, Dorey JM, Dubertret C, Dubreucq J, Faget C, Gabayet F, Le Strat Y, Micoulaud-Franchi JA, Misdrahi D, Rey R, Richieri R, Passerieux C, Schandrin A, Schürhoff F, Tronche AM, Urbach M, Vidalhet P, Llorca PM, Leboyer M; FACE-SZ (FondaMental Academic Centers of Expertise for Schizophrenia) group.
J Affect Disord 2016 Feb;191:209-15. Epub 2015 Nov 26 doi: 10.1016/j.jad.2015.11.017. PMID: 26674214
Brouwers C, Christensen SB, Damen NL, Denollet J, Torp-Pedersen C, Gislason GH, Pedersen SS
Int J Cardiol 2016 Jan 15;203:867-73. Epub 2015 Nov 6 doi: 10.1016/j.ijcard.2015.11.032. PMID: 26599753
Iaboni A, Seitz DP, Fischer HD, Diong CC, Rochon PA, Flint AJ
Am J Geriatr Psychiatry 2015 Oct;23(10):1007-15. Epub 2014 Oct 16 doi: 10.1016/j.jagp.2014.10.002. PMID: 25488107

Therapy

Bushnell GA, Stürmer T, Gaynes BN, Pate V, Miller M
JAMA Psychiatry 2017 Jul 1;74(7):747-755. doi: 10.1001/jamapsychiatry.2017.1273. PMID: 28593281
García-González J, Tansey KE, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Žagar T, Czerski PM, Jerman B, Buttenschøn HN, Schulze TG, Zobel A, Farmer A, Aitchison KJ, Craig I, McGuffin P, Giupponi M, Perroud N, Bondolfi G, Evans D, O'Donovan M, Peters TJ, Wendland JR, Lewis G, Kapur S, Perlis R, Arolt V, Domschke K; Major Depressive Disorder Working Group of the Psychiatric Genomic Consortium., Breen G, Curtis C, Sang-Hyuk L, Kan C, Newhouse S, Patel H, Baune BT, Uher R, Lewis CM, Fabbri C
Prog Neuropsychopharmacol Biol Psychiatry 2017 Apr 3;75:128-134. Epub 2017 Jan 31 doi: 10.1016/j.pnpbp.2017.01.011. PMID: 28159590
Braunstein D, Hardy A, Boucherie Q, Frauger E, Blin O, Gentile G, Micallef J
Fundam Clin Pharmacol 2017 Apr;31(2):226-236. Epub 2017 Jan 10 doi: 10.1111/fcp.12252. PMID: 27862243
du Jardin KG, Müller HK, Elfving B, Dale E, Wegener G, Sanchez C
Prog Neuropsychopharmacol Biol Psychiatry 2016 Nov 3;71:27-38. Epub 2016 Jun 2 doi: 10.1016/j.pnpbp.2016.05.007. PMID: 27262695
Bot M, Milaneschi Y, Penninx BW, Drent ML
Psychoneuroendocrinology 2016 Jun;68:148-55. Epub 2016 Feb 27 doi: 10.1016/j.psyneuen.2016.02.028. PMID: 26974499

Prognosis

García-González J, Tansey KE, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Žagar T, Czerski PM, Jerman B, Buttenschøn HN, Schulze TG, Zobel A, Farmer A, Aitchison KJ, Craig I, McGuffin P, Giupponi M, Perroud N, Bondolfi G, Evans D, O'Donovan M, Peters TJ, Wendland JR, Lewis G, Kapur S, Perlis R, Arolt V, Domschke K; Major Depressive Disorder Working Group of the Psychiatric Genomic Consortium., Breen G, Curtis C, Sang-Hyuk L, Kan C, Newhouse S, Patel H, Baune BT, Uher R, Lewis CM, Fabbri C
Prog Neuropsychopharmacol Biol Psychiatry 2017 Apr 3;75:128-134. Epub 2017 Jan 31 doi: 10.1016/j.pnpbp.2017.01.011. PMID: 28159590
Nielsen MB, Madsen IE, Aust B, Burr H, Rugulies R
J Affect Disord 2016 May 15;196:248-51. Epub 2016 Feb 17 doi: 10.1016/j.jad.2016.02.038. PMID: 26943941
Brouwers C, Christensen SB, Damen NL, Denollet J, Torp-Pedersen C, Gislason GH, Pedersen SS
Int J Cardiol 2016 Jan 15;203:867-73. Epub 2015 Nov 6 doi: 10.1016/j.ijcard.2015.11.032. PMID: 26599753
Paige E, Korda R, Kemp-Casey A, Rodgers B, Dobbins T, Banks E
Aust N Z J Psychiatry 2015 Nov;49(11):1029-39. Epub 2015 Oct 1 doi: 10.1177/0004867415607365. PMID: 26427511
Burton C, Cochran AJ, Cameron IM
Fam Pract 2015 Oct;32(5):520-4. Epub 2015 Aug 5 doi: 10.1093/fampra/cmv063. PMID: 26251027

Clinical prediction guides

Bushnell GA, Stürmer T, Gaynes BN, Pate V, Miller M
JAMA Psychiatry 2017 Jul 1;74(7):747-755. doi: 10.1001/jamapsychiatry.2017.1273. PMID: 28593281
Carrière I, Norton J, Farré A, Wyart M, Tzourio C, Noize P, Pérès K, Fourrier-Réglat A, Ritchie K, Ancelin ML
BMC Med 2017 Apr 19;15(1):81. doi: 10.1186/s12916-017-0847-z. PMID: 28424070Free PMC Article
García-González J, Tansey KE, Hauser J, Henigsberg N, Maier W, Mors O, Placentino A, Rietschel M, Souery D, Žagar T, Czerski PM, Jerman B, Buttenschøn HN, Schulze TG, Zobel A, Farmer A, Aitchison KJ, Craig I, McGuffin P, Giupponi M, Perroud N, Bondolfi G, Evans D, O'Donovan M, Peters TJ, Wendland JR, Lewis G, Kapur S, Perlis R, Arolt V, Domschke K; Major Depressive Disorder Working Group of the Psychiatric Genomic Consortium., Breen G, Curtis C, Sang-Hyuk L, Kan C, Newhouse S, Patel H, Baune BT, Uher R, Lewis CM, Fabbri C
Prog Neuropsychopharmacol Biol Psychiatry 2017 Apr 3;75:128-134. Epub 2017 Jan 31 doi: 10.1016/j.pnpbp.2017.01.011. PMID: 28159590
Bot M, Milaneschi Y, Penninx BW, Drent ML
Psychoneuroendocrinology 2016 Jun;68:148-55. Epub 2016 Feb 27 doi: 10.1016/j.psyneuen.2016.02.028. PMID: 26974499
Nielsen MB, Madsen IE, Aust B, Burr H, Rugulies R
J Affect Disord 2016 May 15;196:248-51. Epub 2016 Feb 17 doi: 10.1016/j.jad.2016.02.038. PMID: 26943941

Recent systematic reviews

Viuff AC, Pedersen LH, Kyng K, Staunstrup NH, Børglum A, Henriksen TB
Clin Epigenetics 2016;8(1):94. Epub 2016 Sep 7 doi: 10.1186/s13148-016-0262-x. PMID: 27610205Free PMC Article
Song GM, Tian X, Shuai T, Yi LJ, Zeng Z, Liu S, Zhou JG, Wang Y
Medicine (Baltimore) 2015 Jul;94(26):e1052. doi: 10.1097/MD.0000000000001052. PMID: 26131818Free PMC Article
Zhao X, Huang Y, Li D, Han C, Kan Q
Psychiatr Genet 2015 Feb;25(1):1-8. doi: 10.1097/YPG.0000000000000070. PMID: 25419635
Cox GR, Callahan P, Churchill R, Hunot V, Merry SN, Parker AG, Hetrick SE
Cochrane Database Syst Rev 2014 Nov 30;(11):CD008324. doi: 10.1002/14651858.CD008324.pub3. PMID: 25433518
Lopresti AL, Drummond PD
Hum Psychopharmacol 2014 Nov;29(6):517-27. Epub 2014 Sep 22 doi: 10.1002/hup.2434. PMID: 25384672

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