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Items: 1 to 20 of 22

1.

Carcinogenesis

The process by which normal cells are transformed into cancer cells. [from NCI_NCI-GLOSS]

MedGen UID:
154544
Concept ID:
C0596263
Neoplastic Process
2.

DNA Methylation

The process by which methyl groups are added to nucleotides in genomic DNA. [from NCI]

MedGen UID:
138191
Concept ID:
C0376452
Molecular Function
3.

Methylation

The covalent chemical or biochemical addition of a methyl group(s) to a compound. (NCI) [from NCI]

MedGen UID:
44400
Concept ID:
C0025723
Molecular Function
4.

Sodium bisulfite

MedGen UID:
35902
Concept ID:
C0074726
Inorganic Chemical; Pharmacologic Substance
5.

Serine

Amino acid with side chain -CH2OH. [from NCI_CRCH]

MedGen UID:
11382
Concept ID:
C0036720
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
6.

Lysine

an essential amino acid [from CHV]

MedGen UID:
7421
Concept ID:
C0024337
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
7.

Down-regulation

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. [from MeSH]

MedGen UID:
4386
Concept ID:
C0013081
Molecular Function
8.

Fanconi-Bickel syndrome

Fanconi-Bickel syndrome is a rare but well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose (Manz et al., 1987). Because no underlying enzymatic defect in carbohydrate metabolism had been identified and because metabolism of both glucose and galactose is impaired, a primary defect of monosaccharide transport across the membranes had been suggested (Berry et al., 1995; Fellers et al., 1967; Manz et al., 1987; Odievre, 1966). Use of the term glycogenosis type XI introduced by Hug (1987) is to be discouraged because glycogen accumulation is not due to the proposed functional defect of phosphoglucomutase, an essential enzyme in the common degradative pathways of both glycogen and galactose, but is secondary to nonfunctional glucose transport. [from OMIM]

MedGen UID:
501176
Concept ID:
C3495427
Disease or Syndrome
9.

Cell Invasion

The movement of one cell type into an area normally occupied by a different cell type. [from NCI]

MedGen UID:
397081
Concept ID:
C2699153
Pathologic Function
10.

Histone deacetylase inhibitor

Any substance that inhibits histone deacetylase, an enzyme that catalyzes the removal of acetyl groups from core histones. Inhibition of histone deacetylase can result in hyperacetylation of histones, with an effect on gene expression and cell differentiation. [from NCI]

MedGen UID:
268200
Concept ID:
C1512474
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
11.

Serpin

Irreversible serine proteinase inhibitors that exert their action on peptidases. Serpins can be localized inside, or outside of the cell, and are found in all groups of organisms with the exception of fungi. In human plasma, serpins represent approximately 2% of the total protein present. [from NCI]

MedGen UID:
48634
Concept ID:
C0036764
Amino Acid, Peptide, or Protein; Biologically Active Substance; Pharmacologic Substance
12.

Serine Proteinase Inhibitors

A protein that plays a role in the inhibition of serine proteinases. [from NCI]

MedGen UID:
20708
Concept ID:
C0036733
Biologically Active Substance; Pharmacologic Substance
13.

Protease Inhibitors

A compound that interferes with the ability of certain enzymes to break down proteins. Some protease inhibitors can keep a virus from making copies of itself (for example, AIDS virus protease inhibitors), and some can prevent cancer cells from spreading. [from NCI_NCI-GLOSS]

MedGen UID:
18701
Concept ID:
C0033607
Pharmacologic Substance
14.

Vidaza

MedGen UID:
288801
Concept ID:
C1563756
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
15.

Molecular Mechanisms of Pharmacological Action

Pharmacological activities at the molecular level of DRUGS and other exogenous compounds that are used to treat DISEASES and affect normal BIOCHEMISTRY. [from MeSH]

MedGen UID:
226255
Concept ID:
C1258062
Molecular Function
16.

NSC-102816

MedGen UID:
209173
Concept ID:
C0878254
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
17.

Enzyme Inhibitors

compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction. [from CRISP]

MedGen UID:
8652
Concept ID:
C0014432
Pharmacologic Substance
18.

Azacitidine

A drug that is used to treat myelodysplastic syndromes and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called antimetabolites. [from NCI_NCI-GLOSS]

MedGen UID:
467
Concept ID:
C0004475
Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
19.

Serpinb5 protein, mouse

MedGen UID:
292788
Concept ID:
C1568103
Amino Acid, Peptide, or Protein; Pharmacologic Substance
20.

Serpinb5 protein, rat

MedGen UID:
291504
Concept ID:
C1568104
Amino Acid, Peptide, or Protein; Pharmacologic Substance
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