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Items: 1 to 20 of 34

1.

Myelodysplasia

Clonal hematopoietic stem cell disorders characterized by dysplasia (ineffective production) in one or more hematopoietic cell lineages, leading to anemia and cytopenia. [from HPO]

MedGen UID:
483005
Concept ID:
C3463824
Neoplastic Process
2.

Acute myeloid leukemia

CEBPA-associated familial acute myeloid leukemia (AML) is defined as AML in which a heterozygous germline CEBPA pathogenic variant is present in a family in which multiple individuals have AML. In contrast, sporadic CEBPA-associated AML is defined as AML in which a CEBPA pathogenic variant(s) is identified in leukemic cells but not in the non-leukemic cells. Too few individuals with CEBPA-associated familial AML have been reported to be certain about the natural history of the disease. In the majority of individuals, the age of onset of familial AML appears to be earlier than sporadic AML; disease onset has been reported in persons as young as age 1.8 years and older than age 45 years. The prognosis of CEBPA-associated familial AML appears to be favorable compared with sporadic CEBPA-associated AML. Individuals with CEBPA-associated familial AML who have been cured of their initial disease may be at greater risk of developing additional independent leukemic episodes in addition to the risk of relapse due to preexisting clones. [from GTR]

MedGen UID:
9730
Concept ID:
C0023467
Neoplastic Process
3.

Leukemia

A cancer of the blood and bone marrow characterized by an abnormal proliferation of leukocytes. [from HPO]

MedGen UID:
9725
Concept ID:
C0023418
Neoplastic Process
4.

Acute myeloid leukemia

A form of leukemia characterized by overproduction of an early myeloid cell. [from HPO]

MedGen UID:
505691
Concept ID:
CN004254
Finding
5.

Infection

The invasion of an organism's body tissues by disease-causing agents and their multiplication, as well as the reaction by the host to these organisms and/or toxins that the organisms produce. [from NCI]

MedGen UID:
811352
Concept ID:
C3714514
Pathologic Function
6.

Histone deacetylase inhibitor

Any substance that inhibits histone deacetylase, an enzyme that catalyzes the removal of acetyl groups from core histones. Inhibition of histone deacetylase can result in hyperacetylation of histones, with an effect on gene expression and cell differentiation. [from NCI]

MedGen UID:
268200
Concept ID:
C1512474
Amino Acid, Peptide, or Protein; Enzyme; Pharmacologic Substance
7.

Febrile neutropenia

Fever accompanied by a significant reduction in the number of NEUTROPHILS. [from MeSH]

MedGen UID:
152883
Concept ID:
C0746883
Disease or Syndrome
8.

Thrombocytopenia

A laboratory test result indicating that there is an abnormally small number of platelets in the circulating blood. [from NCI]

MedGen UID:
52737
Concept ID:
C0040034
Disease or Syndrome
9.

Fatigue

A subjective feeling of tiredness characterized by a lack of energy and motivation. [from HPO]

MedGen UID:
41971
Concept ID:
C0015672
Sign or Symptom
10.

Hypophosphatemia

A condition of an abnormally low level of PHOSPHATES in the blood. [from MeSH]

MedGen UID:
39327
Concept ID:
C0085682
Disease or Syndrome
11.

Neutropenic disorder

A decrease in the number of NEUTROPHILS found in the blood. [from MeSH]

MedGen UID:
18030
Concept ID:
C0027947
Disease or Syndrome
12.

Experimental Tumor

Laboratory tumor models used to study tumor development and treatment. [from NCI]

MedGen UID:
10216
Concept ID:
C0027659
Experimental Model of Disease; Neoplastic Process
13.

Nausea

A sensation of unease in the stomach together with an urge to vomit. [from HPO]

MedGen UID:
10196
Concept ID:
C0027497
Sign or Symptom
14.

Acetylation

Acetylation involves the covalent linkage of an acetyl group into an organic molecule. [from NCI]

MedGen UID:
7840
Concept ID:
C0001038
Molecular Function
15.

Myeloid leukemia

A clonal proliferation of myeloid cells and their precursors in the bone marrow, peripheral blood, and spleen. When the proliferating cells are immature myeloid cells and myeloblasts, it is called acute myeloid leukemia. When the proliferating myeloid cells are neutrophils, it is called chronic myelogenous leukemia. [from NCI]

MedGen UID:
7320
Concept ID:
C0023470
Neoplastic Process
16.

Hypophosphatemia

Lower than normal levels of phosphates in the circulating blood. [from NCI]

MedGen UID:
777035
Concept ID:
C0595888
Finding
17.

3/4

MedGen UID:
617755
Concept ID:
C0442757
Finding
18.

Thrombocytopenia

MedGen UID:
472158
Concept ID:
CN130080
Disease or Syndrome
19.

Neutropenia

A decrease in the number of neutrophils in the peripheral blood. [from NCI]

MedGen UID:
163121
Concept ID:
C0853697
Finding
20.

Remission phase

An abatement in intensity or degree (as in the manifestations of a disease). [from NCI]

MedGen UID:
154255
Concept ID:
C0544452
Finding
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